Preclinical models in electrochemotherapy: The role of veterinary patients

Enrico Pierluigi Spugnini, Maurizio Fanciulli, Gennaro Citro, Alfonso Baldi

Research output: Contribution to journalArticlepeer-review

Abstract

Electrochemotherapy is a tumor treatment that adapts the systemic or local delivery of anticancer drugs by the application of permeabilizing electric pulses with appropriate amplitude and waveforms. This allows the use of lipophobic drugs, which frequently have a narrow therapeutic index, with a decreased morbidity for the patient, while maintaining appropriate anticancer efficacy. Electrochemotherapy is used in humans for the treatment of cutaneous neoplasms or the palliation of skin tumor metastases, and a standard operating procedure has been devised. In veterinary oncology, the electrochemotherapy approach is gaining popularity, becoming a first-line treatment in consideration of its high efficacy and low toxicity. This review summarizes the state of the art in veterinary oncology as a preclinical model.

Original languageEnglish
Pages (from-to)829-837
Number of pages9
JournalFuture Oncology
Volume8
Issue number7
DOIs
Publication statusPublished - Jul 2012

Keywords

  • anthracenediones
  • bleomycin
  • cisplatin
  • companion animal
  • electroporation
  • mitoxantrone
  • therapeutic index

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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