Abstract
Electrochemotherapy is a tumor treatment that adapts the systemic or local delivery of anticancer drugs by the application of permeabilizing electric pulses with appropriate amplitude and waveforms. This allows the use of lipophobic drugs, which frequently have a narrow therapeutic index, with a decreased morbidity for the patient, while maintaining appropriate anticancer efficacy. Electrochemotherapy is used in humans for the treatment of cutaneous neoplasms or the palliation of skin tumor metastases, and a standard operating procedure has been devised. In veterinary oncology, the electrochemotherapy approach is gaining popularity, becoming a first-line treatment in consideration of its high efficacy and low toxicity. This review summarizes the state of the art in veterinary oncology as a preclinical model.
Original language | English |
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Pages (from-to) | 829-837 |
Number of pages | 9 |
Journal | Future Oncology |
Volume | 8 |
Issue number | 7 |
DOIs | |
Publication status | Published - Jul 2012 |
Keywords
- anthracenediones
- bleomycin
- cisplatin
- companion animal
- electroporation
- mitoxantrone
- therapeutic index
ASJC Scopus subject areas
- Oncology
- Cancer Research