Precocius puberty and body composition: Effects of GnRH analog treatment

G. Chiumello, P. Brambilla, M. P. Guarneri, G. Russo, P. Manzoni, P. Sgaramella

Research output: Contribution to journalArticlepeer-review


Introduction: Body composition changes with age and sex differences become significant only after puberty. Boys and girls before the age of 8 yr do not differ in fat, lean or bone mineral mass. Hormonal influences during pubertal development determine the physiological adult male and female body composition phenotype. Aim: The aim of our study was to evaluate body composition changes due to central precocious puberty (PP) and the specific effects of therapy on these modifications. Subjects and methods: Sixteen patients (14 girls, 2 boys) were included in the study. They were diagnosed as affected by idiopathic PP according to standard hormonal and clinical criteria; anatomic alterations of hypothalamus-hypophysis region were excluded by MRI. Mean age at diagnosis was 5.9 ± 1.9 yr. All patients received GnRH analog (Leuprolide or Triptorelin) treatment subcutaneously every 4 weeks for at least 1 yr. Mean period of treatment was 3.4 ± 1.9 yr. Standard anthropometry and body composition analysis were performed at baseline and every 6-12 months. A group of healthy subjects with normal timing of puberty was matched (for age or for pubertal stage) served as the control group (CA or CP, respectively). Results: Patients with PP showed at baseline a significant increase of BMI and relative body weight; lean and fat compartments were also increased but not significantly. During treatment, the PP group showed increased fat mass compared to CA (p

Original languageEnglish
Pages (from-to)791-794
Number of pages4
JournalJournal of Pediatric Endocrinology and Metabolism
Issue numberSUPPL. 1
Publication statusPublished - 2000


  • Body composition
  • Fat mass
  • GnRH analog
  • Lean mass
  • Precocious puberty

ASJC Scopus subject areas

  • Endocrinology
  • Pediatrics, Perinatology, and Child Health


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