Precocius puberty and body composition: Effects of GnRH analog treatment

G. Chiumello, P. Brambilla, M. P. Guarneri, G. Russo, P. Manzoni, P. Sgaramella

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Introduction: Body composition changes with age and sex differences become significant only after puberty. Boys and girls before the age of 8 yr do not differ in fat, lean or bone mineral mass. Hormonal influences during pubertal development determine the physiological adult male and female body composition phenotype. Aim: The aim of our study was to evaluate body composition changes due to central precocious puberty (PP) and the specific effects of therapy on these modifications. Subjects and methods: Sixteen patients (14 girls, 2 boys) were included in the study. They were diagnosed as affected by idiopathic PP according to standard hormonal and clinical criteria; anatomic alterations of hypothalamus-hypophysis region were excluded by MRI. Mean age at diagnosis was 5.9 ± 1.9 yr. All patients received GnRH analog (Leuprolide or Triptorelin) treatment subcutaneously every 4 weeks for at least 1 yr. Mean period of treatment was 3.4 ± 1.9 yr. Standard anthropometry and body composition analysis were performed at baseline and every 6-12 months. A group of healthy subjects with normal timing of puberty was matched (for age or for pubertal stage) served as the control group (CA or CP, respectively). Results: Patients with PP showed at baseline a significant increase of BMI and relative body weight; lean and fat compartments were also increased but not significantly. During treatment, the PP group showed increased fat mass compared to CA (p

Original languageEnglish
Pages (from-to)791-794
Number of pages4
JournalJournal of Pediatric Endocrinology and Metabolism
Volume13
Issue numberSUPPL. 1
Publication statusPublished - 2000

Fingerprint

Puberty
Body Composition
Precocious Puberty
Gonadotropin-Releasing Hormone
Fats
Triptorelin Pamoate
Leuprolide
Anthropometry
Pituitary Gland
Therapeutics
Sex Characteristics
Hypothalamus
Minerals
Healthy Volunteers
Body Weight
Phenotype
Bone and Bones
Control Groups

Keywords

  • Body composition
  • Fat mass
  • GnRH analog
  • Lean mass
  • Precocious puberty

ASJC Scopus subject areas

  • Endocrinology
  • Pediatrics, Perinatology, and Child Health

Cite this

Chiumello, G., Brambilla, P., Guarneri, M. P., Russo, G., Manzoni, P., & Sgaramella, P. (2000). Precocius puberty and body composition: Effects of GnRH analog treatment. Journal of Pediatric Endocrinology and Metabolism, 13(SUPPL. 1), 791-794.

Precocius puberty and body composition : Effects of GnRH analog treatment. / Chiumello, G.; Brambilla, P.; Guarneri, M. P.; Russo, G.; Manzoni, P.; Sgaramella, P.

In: Journal of Pediatric Endocrinology and Metabolism, Vol. 13, No. SUPPL. 1, 2000, p. 791-794.

Research output: Contribution to journalArticle

Chiumello, G, Brambilla, P, Guarneri, MP, Russo, G, Manzoni, P & Sgaramella, P 2000, 'Precocius puberty and body composition: Effects of GnRH analog treatment', Journal of Pediatric Endocrinology and Metabolism, vol. 13, no. SUPPL. 1, pp. 791-794.
Chiumello G, Brambilla P, Guarneri MP, Russo G, Manzoni P, Sgaramella P. Precocius puberty and body composition: Effects of GnRH analog treatment. Journal of Pediatric Endocrinology and Metabolism. 2000;13(SUPPL. 1):791-794.
Chiumello, G. ; Brambilla, P. ; Guarneri, M. P. ; Russo, G. ; Manzoni, P. ; Sgaramella, P. / Precocius puberty and body composition : Effects of GnRH analog treatment. In: Journal of Pediatric Endocrinology and Metabolism. 2000 ; Vol. 13, No. SUPPL. 1. pp. 791-794.
@article{7f94170871744dd8bc0ff8e9e7b96b74,
title = "Precocius puberty and body composition: Effects of GnRH analog treatment",
abstract = "Introduction: Body composition changes with age and sex differences become significant only after puberty. Boys and girls before the age of 8 yr do not differ in fat, lean or bone mineral mass. Hormonal influences during pubertal development determine the physiological adult male and female body composition phenotype. Aim: The aim of our study was to evaluate body composition changes due to central precocious puberty (PP) and the specific effects of therapy on these modifications. Subjects and methods: Sixteen patients (14 girls, 2 boys) were included in the study. They were diagnosed as affected by idiopathic PP according to standard hormonal and clinical criteria; anatomic alterations of hypothalamus-hypophysis region were excluded by MRI. Mean age at diagnosis was 5.9 ± 1.9 yr. All patients received GnRH analog (Leuprolide or Triptorelin) treatment subcutaneously every 4 weeks for at least 1 yr. Mean period of treatment was 3.4 ± 1.9 yr. Standard anthropometry and body composition analysis were performed at baseline and every 6-12 months. A group of healthy subjects with normal timing of puberty was matched (for age or for pubertal stage) served as the control group (CA or CP, respectively). Results: Patients with PP showed at baseline a significant increase of BMI and relative body weight; lean and fat compartments were also increased but not significantly. During treatment, the PP group showed increased fat mass compared to CA (p",
keywords = "Body composition, Fat mass, GnRH analog, Lean mass, Precocious puberty",
author = "G. Chiumello and P. Brambilla and Guarneri, {M. P.} and G. Russo and P. Manzoni and P. Sgaramella",
year = "2000",
language = "English",
volume = "13",
pages = "791--794",
journal = "Journal of Pediatric Endocrinology and Metabolism",
issn = "0334-018X",
publisher = "Walter de Gruyter GmbH & Co. KG",
number = "SUPPL. 1",

}

TY - JOUR

T1 - Precocius puberty and body composition

T2 - Effects of GnRH analog treatment

AU - Chiumello, G.

AU - Brambilla, P.

AU - Guarneri, M. P.

AU - Russo, G.

AU - Manzoni, P.

AU - Sgaramella, P.

PY - 2000

Y1 - 2000

N2 - Introduction: Body composition changes with age and sex differences become significant only after puberty. Boys and girls before the age of 8 yr do not differ in fat, lean or bone mineral mass. Hormonal influences during pubertal development determine the physiological adult male and female body composition phenotype. Aim: The aim of our study was to evaluate body composition changes due to central precocious puberty (PP) and the specific effects of therapy on these modifications. Subjects and methods: Sixteen patients (14 girls, 2 boys) were included in the study. They were diagnosed as affected by idiopathic PP according to standard hormonal and clinical criteria; anatomic alterations of hypothalamus-hypophysis region were excluded by MRI. Mean age at diagnosis was 5.9 ± 1.9 yr. All patients received GnRH analog (Leuprolide or Triptorelin) treatment subcutaneously every 4 weeks for at least 1 yr. Mean period of treatment was 3.4 ± 1.9 yr. Standard anthropometry and body composition analysis were performed at baseline and every 6-12 months. A group of healthy subjects with normal timing of puberty was matched (for age or for pubertal stage) served as the control group (CA or CP, respectively). Results: Patients with PP showed at baseline a significant increase of BMI and relative body weight; lean and fat compartments were also increased but not significantly. During treatment, the PP group showed increased fat mass compared to CA (p

AB - Introduction: Body composition changes with age and sex differences become significant only after puberty. Boys and girls before the age of 8 yr do not differ in fat, lean or bone mineral mass. Hormonal influences during pubertal development determine the physiological adult male and female body composition phenotype. Aim: The aim of our study was to evaluate body composition changes due to central precocious puberty (PP) and the specific effects of therapy on these modifications. Subjects and methods: Sixteen patients (14 girls, 2 boys) were included in the study. They were diagnosed as affected by idiopathic PP according to standard hormonal and clinical criteria; anatomic alterations of hypothalamus-hypophysis region were excluded by MRI. Mean age at diagnosis was 5.9 ± 1.9 yr. All patients received GnRH analog (Leuprolide or Triptorelin) treatment subcutaneously every 4 weeks for at least 1 yr. Mean period of treatment was 3.4 ± 1.9 yr. Standard anthropometry and body composition analysis were performed at baseline and every 6-12 months. A group of healthy subjects with normal timing of puberty was matched (for age or for pubertal stage) served as the control group (CA or CP, respectively). Results: Patients with PP showed at baseline a significant increase of BMI and relative body weight; lean and fat compartments were also increased but not significantly. During treatment, the PP group showed increased fat mass compared to CA (p

KW - Body composition

KW - Fat mass

KW - GnRH analog

KW - Lean mass

KW - Precocious puberty

UR - http://www.scopus.com/inward/record.url?scp=0033866568&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033866568&partnerID=8YFLogxK

M3 - Article

C2 - 10969923

AN - SCOPUS:0033866568

VL - 13

SP - 791

EP - 794

JO - Journal of Pediatric Endocrinology and Metabolism

JF - Journal of Pediatric Endocrinology and Metabolism

SN - 0334-018X

IS - SUPPL. 1

ER -