Preconceptional primary human cytomegalovirus infection and risk of congenital infection

Maria Grazia Revello, Maurizio Zavattoni, Milena Furione, Elisa Fabbri, Giuseppe Gerna

Research output: Contribution to journalArticlepeer-review


The risk of vertical transmission of human cytomegalovirus (HCMV) was investigated in 14 women who had primary HCMV infection 2-18 weeks before their last menstrual period during 2001-2004. One (8.3%) of 12 newborns examined at birth was found to be subclinically infected. Preconceptional primary HCMV infection has a transmission rate that is significantly higher than that observed in an unselected newborn population but significantly lower than that associated with maternal infection during pregnancy. Although a safe time interval between primary infection and initiation of pregnancy still needs to be defined, documented information can now be provided during counseling.

Original languageEnglish
Pages (from-to)783-787
Number of pages5
JournalJournal of Infectious Diseases
Issue number6
Publication statusPublished - Mar 15 2006

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology


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