Preconditioning by transient myocardial ischemia confers protection against ischemia-induced ventricular arrhythmias in variant angina

Vincenzo Pasceri, Gaetano A. Lanza, Giuseppe Patti, Patrizia Pedrotti, Filippo Crea, Attilio Maseri

Research output: Contribution to journalArticle

Abstract

Background: In experimental models, ischemic preconditioning of the heart protects against ischemic damage and ventricular arrhythmias during subsequent coronary occlusion. In this study, we investigated whether protection against ischemic suffering and ischemia-induced arrhythmias may occur after spontaneous transmural ischemia in humans. Methods and Results: We performed 24 hour Holter monitoring in 10 patients with variant angina who developed complex ventricular arrhythmias (CVAs, more than five premature ventricular beats per minute or repetitive ventricular arrhythmias) during episodes of ST-segment elevation. A total of 150 episodes of ST-segment elevation were detected on Holter monitoring, 21 (14%) of which showed CVAs. Episodes separated from the previous one by a time interval of ≤30 minutes or by a time interval of >30 minutes did not differ in either magnitude or duration of ST segment elevation, but CVAs occurred more frequently in the second group (3% versus 29%, P

Original languageEnglish
Pages (from-to)1850-1856
Number of pages7
JournalCirculation
Volume94
Issue number8
Publication statusPublished - 1996

Keywords

  • angina
  • arrhythmia

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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