Abstract
It is known that preconditioning the heart with brief periods of ischemia makes it resistant to reperfusion-induced ventricular arrhythmias from a subsequent ischemic insult. However, there are no data available on whether ischemic preconditioning can reduce the incidence of reperfusion-induced ventricular arrhythmias in senescent hearts. In the present study, we examined the development of reperfusion-induced ventricular arrhythmias after 30 min. of total global ischemia in control hearts, and in hearts that had been subjected to preconditioning (5 min of global ischemia and 5 min. of reperfusion) in adult (6 months) and senescent (24 months) isolated rat hearts. The results obtained show that ischemic preconditioning significantly reduces reperfusion-induced ventricular arrhythmias in adult hearts associated with an improvement of end-diastolic and developed pressure. In contrast, the beneficial effects of ischemic preconditioning on reperfusion-induced ventricular arrhythmias and myocardial function were not seen in senescent hearts.
| Original language | English |
|---|---|
| Pages (from-to) | 727-731 |
| Number of pages | 5 |
| Journal | New Trends in Arrhythmias |
| Volume | 9 |
| Issue number | 3 |
| Publication status | Published - 1993 |
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Keywords
- myocardial ischemia
- preconditioning
- reperfusion arrhythmias
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Preconditioning does not prevent reperfusion ventricular arrhythmias in isolated heart of senescent rats. / Abete, P.; Caccese, P.; Abate, R.; Cioppa, A.; Bianco, S.; Ferrara, P.; Landino, P.; Ciaburri, F.; Scaletta, M.; Ferrara, N.; Rengo, F.
In: New Trends in Arrhythmias, Vol. 9, No. 3, 1993, p. 727-731.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Preconditioning does not prevent reperfusion ventricular arrhythmias in isolated heart of senescent rats
AU - Abete, P.
AU - Caccese, P.
AU - Abate, R.
AU - Cioppa, A.
AU - Bianco, S.
AU - Ferrara, P.
AU - Landino, P.
AU - Ciaburri, F.
AU - Scaletta, M.
AU - Ferrara, N.
AU - Rengo, F.
PY - 1993
Y1 - 1993
N2 - It is known that preconditioning the heart with brief periods of ischemia makes it resistant to reperfusion-induced ventricular arrhythmias from a subsequent ischemic insult. However, there are no data available on whether ischemic preconditioning can reduce the incidence of reperfusion-induced ventricular arrhythmias in senescent hearts. In the present study, we examined the development of reperfusion-induced ventricular arrhythmias after 30 min. of total global ischemia in control hearts, and in hearts that had been subjected to preconditioning (5 min of global ischemia and 5 min. of reperfusion) in adult (6 months) and senescent (24 months) isolated rat hearts. The results obtained show that ischemic preconditioning significantly reduces reperfusion-induced ventricular arrhythmias in adult hearts associated with an improvement of end-diastolic and developed pressure. In contrast, the beneficial effects of ischemic preconditioning on reperfusion-induced ventricular arrhythmias and myocardial function were not seen in senescent hearts.
AB - It is known that preconditioning the heart with brief periods of ischemia makes it resistant to reperfusion-induced ventricular arrhythmias from a subsequent ischemic insult. However, there are no data available on whether ischemic preconditioning can reduce the incidence of reperfusion-induced ventricular arrhythmias in senescent hearts. In the present study, we examined the development of reperfusion-induced ventricular arrhythmias after 30 min. of total global ischemia in control hearts, and in hearts that had been subjected to preconditioning (5 min of global ischemia and 5 min. of reperfusion) in adult (6 months) and senescent (24 months) isolated rat hearts. The results obtained show that ischemic preconditioning significantly reduces reperfusion-induced ventricular arrhythmias in adult hearts associated with an improvement of end-diastolic and developed pressure. In contrast, the beneficial effects of ischemic preconditioning on reperfusion-induced ventricular arrhythmias and myocardial function were not seen in senescent hearts.
KW - myocardial ischemia
KW - preconditioning
KW - reperfusion arrhythmias
UR - http://www.scopus.com/inward/record.url?scp=0027728820&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027728820&partnerID=8YFLogxK
M3 - Article
VL - 9
SP - 727
EP - 731
JO - New Trends in Arrhythmias
JF - New Trends in Arrhythmias
SN - 0393-5302
IS - 3
ER -