Abstract
It is known that preconditioning the heart with brief periods of ischemia makes it resistant to reperfusion-induced ventricular arrhythmias from a subsequent ischemic insult. However, there are no data available on whether ischemic preconditioning can reduce the incidence of reperfusion-induced ventricular arrhythmias in senescent hearts. In the present study, we examined the development of reperfusion-induced ventricular arrhythmias after 30 min. of total global ischemia in control hearts, and in hearts that had been subjected to preconditioning (5 min of global ischemia and 5 min. of reperfusion) in adult (6 months) and senescent (24 months) isolated rat hearts. The results obtained show that ischemic preconditioning significantly reduces reperfusion-induced ventricular arrhythmias in adult hearts associated with an improvement of end-diastolic and developed pressure. In contrast, the beneficial effects of ischemic preconditioning on reperfusion-induced ventricular arrhythmias and myocardial function were not seen in senescent hearts.
| Original language | English |
|---|---|
| Pages (from-to) | 727-731 |
| Number of pages | 5 |
| Journal | New Trends in Arrhythmias |
| Volume | 9 |
| Issue number | 3 |
| Publication status | Published - 1993 |
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Keywords
- myocardial ischemia
- preconditioning
- reperfusion arrhythmias
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine