Preconditioning does not prevent reperfusion ventricular arrhythmias in isolated heart of senescent rats

P. Abete, P. Caccese, R. Abate, A. Cioppa, S. Bianco, P. Ferrara, P. Landino, F. Ciaburri, M. Scaletta, N. Ferrara, F. Rengo

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It is known that preconditioning the heart with brief periods of ischemia makes it resistant to reperfusion-induced ventricular arrhythmias from a subsequent ischemic insult. However, there are no data available on whether ischemic preconditioning can reduce the incidence of reperfusion-induced ventricular arrhythmias in senescent hearts. In the present study, we examined the development of reperfusion-induced ventricular arrhythmias after 30 min. of total global ischemia in control hearts, and in hearts that had been subjected to preconditioning (5 min of global ischemia and 5 min. of reperfusion) in adult (6 months) and senescent (24 months) isolated rat hearts. The results obtained show that ischemic preconditioning significantly reduces reperfusion-induced ventricular arrhythmias in adult hearts associated with an improvement of end-diastolic and developed pressure. In contrast, the beneficial effects of ischemic preconditioning on reperfusion-induced ventricular arrhythmias and myocardial function were not seen in senescent hearts.

Original languageEnglish
Pages (from-to)727-731
Number of pages5
JournalNew Trends in Arrhythmias
Issue number3
Publication statusPublished - 1993


  • myocardial ischemia
  • preconditioning
  • reperfusion arrhythmias

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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