Prediagnostic circulating concentrations of plasma insulin-like growth factor-I and risk of lymphoma in the European Prospective Investigation into Cancer and Nutrition

Aurora Perez-Cornago, Paul N Appleby, Sarah Tipper, Timothy J Key, Naomi E Allen, Alexandra Nieters, Roel Vermeulen, Sandrine Roulland, Delphine Casabonne, Rudolf Kaaks, Renee T Fortner, Heiner Boeing, Antonia Trichopoulou, Carlo La Vecchia, Eleni Klinaki, Louise Hansen, Anne Tjønneland, Fabrice Bonnet, Guy Fagherazzi, Marie-Christine Boutron-RuaultValeria Pala, Giovanna Masala, Carlotta Sacerdote, Petra H Peeters, H B As Bueno-de-Mesquita, Elisabete Weiderpass, Miren Dorronsoro, J Ramón Quirós, Aurelio Barricarte, Diana Gavrila, Antonio Agudo, Signe Borgquist, Ann H Rosendahl, Beatrice Melin, Nick Wareham, Kay-Tee Khaw, Marc Gunter, Elio Riboli, Paolo Vineis, Ruth C Travis

Research output: Contribution to journalArticle

Abstract

Insulin-like growth factor (IGF)-I has cancer promoting activities. However, the hypothesis that circulating IGF-I concentration is related to risk of lymphoma overall or its subtypes has not been examined prospectively. IGF-I concentration was measured in pre-diagnostic plasma samples from a nested case-control study of 1,072 cases of lymphoid malignancies and 1,072 individually matched controls from the European Prospective Investigation into Cancer and Nutrition. Odds ratios (ORs) and confidence intervals (CIs) for lymphoma were calculated using conditional logistic regression. IGF-I concentration was not associated with overall lymphoma risk (multivariable-adjusted OR for highest versus lowest third = 0.77 [95% CI = 0.57-1.03], ptrend  = 0.06). There was no statistical evidence of heterogeneity in this association with IGF-I by sex, age at blood collection, time between blood collection and diagnosis, age at diagnosis, or body mass index (pheterogeneity for all  ≥ 0.05). There were no associations between IGF-I concentration and risk for specific BCL subtypes, T-cell lymphoma or Hodgkin lymphoma, although number of cases were small. In this European population, IGF-I concentration was not associated with risk of overall lymphoma. This study provides the first prospective evidence on circulating IGF-I concentrations and risk of lymphoma. Further prospective data are required to examine associations of IGF-I concentrations with lymphoma subtypes.

Original languageEnglish
Pages (from-to)1111-1118
Number of pages8
JournalInternational Journal of Cancer
Volume140
Issue number5
DOIs
Publication statusPublished - Mar 1 2017

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Insulin-Like Growth Factor I
Lymphoma
Neoplasms
Odds Ratio
Confidence Intervals
T-Cell Lymphoma
Hodgkin Disease
Case-Control Studies
Body Mass Index
Logistic Models
Population

Keywords

  • Adult
  • Aged
  • Aged, 80 and over
  • Case-Control Studies
  • Europe
  • Female
  • Follow-Up Studies
  • Humans
  • Insulin-Like Growth Factor I
  • Lymphoma
  • Male
  • Middle Aged
  • Nutrition Surveys
  • Odds Ratio
  • Risk
  • Risk Factors
  • Socioeconomic Factors
  • Journal Article
  • Multicenter Study

Cite this

Prediagnostic circulating concentrations of plasma insulin-like growth factor-I and risk of lymphoma in the European Prospective Investigation into Cancer and Nutrition. / Perez-Cornago, Aurora; Appleby, Paul N; Tipper, Sarah; Key, Timothy J; Allen, Naomi E; Nieters, Alexandra; Vermeulen, Roel; Roulland, Sandrine; Casabonne, Delphine; Kaaks, Rudolf; Fortner, Renee T; Boeing, Heiner; Trichopoulou, Antonia; La Vecchia, Carlo; Klinaki, Eleni; Hansen, Louise; Tjønneland, Anne; Bonnet, Fabrice; Fagherazzi, Guy; Boutron-Ruault, Marie-Christine; Pala, Valeria; Masala, Giovanna; Sacerdote, Carlotta; Peeters, Petra H; Bueno-de-Mesquita, H B As; Weiderpass, Elisabete; Dorronsoro, Miren; Quirós, J Ramón; Barricarte, Aurelio; Gavrila, Diana; Agudo, Antonio; Borgquist, Signe; Rosendahl, Ann H; Melin, Beatrice; Wareham, Nick; Khaw, Kay-Tee; Gunter, Marc; Riboli, Elio; Vineis, Paolo; Travis, Ruth C.

In: International Journal of Cancer, Vol. 140, No. 5, 01.03.2017, p. 1111-1118.

Research output: Contribution to journalArticle

Perez-Cornago, A, Appleby, PN, Tipper, S, Key, TJ, Allen, NE, Nieters, A, Vermeulen, R, Roulland, S, Casabonne, D, Kaaks, R, Fortner, RT, Boeing, H, Trichopoulou, A, La Vecchia, C, Klinaki, E, Hansen, L, Tjønneland, A, Bonnet, F, Fagherazzi, G, Boutron-Ruault, M-C, Pala, V, Masala, G, Sacerdote, C, Peeters, PH, Bueno-de-Mesquita, HBA, Weiderpass, E, Dorronsoro, M, Quirós, JR, Barricarte, A, Gavrila, D, Agudo, A, Borgquist, S, Rosendahl, AH, Melin, B, Wareham, N, Khaw, K-T, Gunter, M, Riboli, E, Vineis, P & Travis, RC 2017, 'Prediagnostic circulating concentrations of plasma insulin-like growth factor-I and risk of lymphoma in the European Prospective Investigation into Cancer and Nutrition', International Journal of Cancer, vol. 140, no. 5, pp. 1111-1118. https://doi.org/10.1002/ijc.30528
Perez-Cornago, Aurora ; Appleby, Paul N ; Tipper, Sarah ; Key, Timothy J ; Allen, Naomi E ; Nieters, Alexandra ; Vermeulen, Roel ; Roulland, Sandrine ; Casabonne, Delphine ; Kaaks, Rudolf ; Fortner, Renee T ; Boeing, Heiner ; Trichopoulou, Antonia ; La Vecchia, Carlo ; Klinaki, Eleni ; Hansen, Louise ; Tjønneland, Anne ; Bonnet, Fabrice ; Fagherazzi, Guy ; Boutron-Ruault, Marie-Christine ; Pala, Valeria ; Masala, Giovanna ; Sacerdote, Carlotta ; Peeters, Petra H ; Bueno-de-Mesquita, H B As ; Weiderpass, Elisabete ; Dorronsoro, Miren ; Quirós, J Ramón ; Barricarte, Aurelio ; Gavrila, Diana ; Agudo, Antonio ; Borgquist, Signe ; Rosendahl, Ann H ; Melin, Beatrice ; Wareham, Nick ; Khaw, Kay-Tee ; Gunter, Marc ; Riboli, Elio ; Vineis, Paolo ; Travis, Ruth C. / Prediagnostic circulating concentrations of plasma insulin-like growth factor-I and risk of lymphoma in the European Prospective Investigation into Cancer and Nutrition. In: International Journal of Cancer. 2017 ; Vol. 140, No. 5. pp. 1111-1118.
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abstract = "Insulin-like growth factor (IGF)-I has cancer promoting activities. However, the hypothesis that circulating IGF-I concentration is related to risk of lymphoma overall or its subtypes has not been examined prospectively. IGF-I concentration was measured in pre-diagnostic plasma samples from a nested case-control study of 1,072 cases of lymphoid malignancies and 1,072 individually matched controls from the European Prospective Investigation into Cancer and Nutrition. Odds ratios (ORs) and confidence intervals (CIs) for lymphoma were calculated using conditional logistic regression. IGF-I concentration was not associated with overall lymphoma risk (multivariable-adjusted OR for highest versus lowest third = 0.77 [95{\%} CI = 0.57-1.03], ptrend  = 0.06). There was no statistical evidence of heterogeneity in this association with IGF-I by sex, age at blood collection, time between blood collection and diagnosis, age at diagnosis, or body mass index (pheterogeneity for all  ≥ 0.05). There were no associations between IGF-I concentration and risk for specific BCL subtypes, T-cell lymphoma or Hodgkin lymphoma, although number of cases were small. In this European population, IGF-I concentration was not associated with risk of overall lymphoma. This study provides the first prospective evidence on circulating IGF-I concentrations and risk of lymphoma. Further prospective data are required to examine associations of IGF-I concentrations with lymphoma subtypes.",
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AU - Perez-Cornago, Aurora

AU - Appleby, Paul N

AU - Tipper, Sarah

AU - Key, Timothy J

AU - Allen, Naomi E

AU - Nieters, Alexandra

AU - Vermeulen, Roel

AU - Roulland, Sandrine

AU - Casabonne, Delphine

AU - Kaaks, Rudolf

AU - Fortner, Renee T

AU - Boeing, Heiner

AU - Trichopoulou, Antonia

AU - La Vecchia, Carlo

AU - Klinaki, Eleni

AU - Hansen, Louise

AU - Tjønneland, Anne

AU - Bonnet, Fabrice

AU - Fagherazzi, Guy

AU - Boutron-Ruault, Marie-Christine

AU - Pala, Valeria

AU - Masala, Giovanna

AU - Sacerdote, Carlotta

AU - Peeters, Petra H

AU - Bueno-de-Mesquita, H B As

AU - Weiderpass, Elisabete

AU - Dorronsoro, Miren

AU - Quirós, J Ramón

AU - Barricarte, Aurelio

AU - Gavrila, Diana

AU - Agudo, Antonio

AU - Borgquist, Signe

AU - Rosendahl, Ann H

AU - Melin, Beatrice

AU - Wareham, Nick

AU - Khaw, Kay-Tee

AU - Gunter, Marc

AU - Riboli, Elio

AU - Vineis, Paolo

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N2 - Insulin-like growth factor (IGF)-I has cancer promoting activities. However, the hypothesis that circulating IGF-I concentration is related to risk of lymphoma overall or its subtypes has not been examined prospectively. IGF-I concentration was measured in pre-diagnostic plasma samples from a nested case-control study of 1,072 cases of lymphoid malignancies and 1,072 individually matched controls from the European Prospective Investigation into Cancer and Nutrition. Odds ratios (ORs) and confidence intervals (CIs) for lymphoma were calculated using conditional logistic regression. IGF-I concentration was not associated with overall lymphoma risk (multivariable-adjusted OR for highest versus lowest third = 0.77 [95% CI = 0.57-1.03], ptrend  = 0.06). There was no statistical evidence of heterogeneity in this association with IGF-I by sex, age at blood collection, time between blood collection and diagnosis, age at diagnosis, or body mass index (pheterogeneity for all  ≥ 0.05). There were no associations between IGF-I concentration and risk for specific BCL subtypes, T-cell lymphoma or Hodgkin lymphoma, although number of cases were small. In this European population, IGF-I concentration was not associated with risk of overall lymphoma. This study provides the first prospective evidence on circulating IGF-I concentrations and risk of lymphoma. Further prospective data are required to examine associations of IGF-I concentrations with lymphoma subtypes.

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KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Case-Control Studies

KW - Europe

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Insulin-Like Growth Factor I

KW - Lymphoma

KW - Male

KW - Middle Aged

KW - Nutrition Surveys

KW - Odds Ratio

KW - Risk

KW - Risk Factors

KW - Socioeconomic Factors

KW - Journal Article

KW - Multicenter Study

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DO - 10.1002/ijc.30528

M3 - Article

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VL - 140

SP - 1111

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JO - International Journal of Cancer

JF - International Journal of Cancer

SN - 0020-7136

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