Prediagnostic concentrations of plasma genistein and prostate cancer risk in 1,605 men with prostate cancer and 1,697 matched control participants in EPIC

Ruth C. Travis, Naomi E. Allen, Paul N. Appleby, Alison Price, Rudolf Kaaks, Jenny Chang-Claude, Heiner Boeing, Krasimira Aleksandrova, Anne Tjønneland, Nina Føns Johnsen, Kim Overvad, J. Ramón Quirós, Carlos A. González, Esther Molina-Montes, Maria José Sánchez, Nerea Larrañaga, José María Huerta Castaño, Eva Ardanaz, Kay Tee Khaw, Nick WarehamAntonia Trichopoulou, Tina Karapetyan, Snorri Bjorn Rafnsson, Domenico Palli, Vittorio Krogh, Rosario Tumino, Paolo Vineis, H. Bas Bueno-De-Mesquita, Pär Stattin, Mattias Johansson, Veronika Fedirko, Teresa Norat, Afshan Siddiq, Elio Riboli, Timothy J. Key

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: Data from prospective epidemiological studies in Asian populations and from experimental studies in animals and cell lines suggest a possible protective association between dietary isoflavones and the development of prostate cancer. We examined the association between circulating concentrations of genistein and prostate cancer risk in a case-control study nested in the European Prospective Investigation into Cancer and Nutrition. Methods: Concentrations of the isoflavone genistein were measured in prediagnostic plasma samples for 1,605 prostate cancer cases and 1,697 matched control participants. Relative risks (RRs) for prostate cancer in relation to plasma concentrations of genistein were estimated by conditional logistic regression. Results: Plasma genistein concentrations were not associated with prostate cancer risk; the multivariate relative risk for men in the highest fifth of genistein compared with men in the lowest fifth was 1.00 (95 % confidence interval: 0.79, 1.27; p linear trend = 0.82). There was no evidence of heterogeneity in this association by age at blood collection, country of recruitment, or cancer stage or histological grade. Conclusion: Plasma genistein concentration was not associated with prostate cancer risk in this large cohort of European men.

Original languageEnglish
Pages (from-to)1163-1171
Number of pages9
JournalCancer Causes and Control
Volume23
Issue number7
DOIs
Publication statusPublished - Jul 2012

Keywords

  • Genistein
  • Isoflavone
  • Phyto-estrogen
  • Plasma
  • Prospective
  • Prostate cancer

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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