Prediagnostic concentrations of plasma genistein and prostate cancer risk in 1,605 men with prostate cancer and 1,697 matched control participants in EPIC

Ruth C. Travis, Naomi E. Allen, Paul N. Appleby, Alison Price, Rudolf Kaaks, Jenny Chang-Claude, Heiner Boeing, Krasimira Aleksandrova, Anne Tjønneland, Nina Føns Johnsen, Kim Overvad, J. Ramón Quirós, Carlos A. González, Esther Molina-Montes, Maria José Sánchez, Nerea Larrañaga, José María Huerta Castaño, Eva Ardanaz, Kay Tee Khaw, Nick WarehamAntonia Trichopoulou, Tina Karapetyan, Snorri Bjorn Rafnsson, Domenico Palli, Vittorio Krogh, Rosario Tumino, Paolo Vineis, H. Bas Bueno-De-Mesquita, Pär Stattin, Mattias Johansson, Veronika Fedirko, Teresa Norat, Afshan Siddiq, Elio Riboli, Timothy J. Key

Research output: Contribution to journalArticle

Abstract

Purpose: Data from prospective epidemiological studies in Asian populations and from experimental studies in animals and cell lines suggest a possible protective association between dietary isoflavones and the development of prostate cancer. We examined the association between circulating concentrations of genistein and prostate cancer risk in a case-control study nested in the European Prospective Investigation into Cancer and Nutrition. Methods: Concentrations of the isoflavone genistein were measured in prediagnostic plasma samples for 1,605 prostate cancer cases and 1,697 matched control participants. Relative risks (RRs) for prostate cancer in relation to plasma concentrations of genistein were estimated by conditional logistic regression. Results: Plasma genistein concentrations were not associated with prostate cancer risk; the multivariate relative risk for men in the highest fifth of genistein compared with men in the lowest fifth was 1.00 (95 % confidence interval: 0.79, 1.27; p linear trend = 0.82). There was no evidence of heterogeneity in this association by age at blood collection, country of recruitment, or cancer stage or histological grade. Conclusion: Plasma genistein concentration was not associated with prostate cancer risk in this large cohort of European men.

Original languageEnglish
Pages (from-to)1163-1171
Number of pages9
JournalCancer Causes and Control
Volume23
Issue number7
DOIs
Publication statusPublished - Jul 2012

Fingerprint

Genistein
Prostatic Neoplasms
Isoflavones
Case-Control Studies
Epidemiologic Studies
Neoplasms
Logistic Models
Prospective Studies
Confidence Intervals
Cell Line
Population

Keywords

  • Genistein
  • Isoflavone
  • Phyto-estrogen
  • Plasma
  • Prospective
  • Prostate cancer

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Prediagnostic concentrations of plasma genistein and prostate cancer risk in 1,605 men with prostate cancer and 1,697 matched control participants in EPIC. / Travis, Ruth C.; Allen, Naomi E.; Appleby, Paul N.; Price, Alison; Kaaks, Rudolf; Chang-Claude, Jenny; Boeing, Heiner; Aleksandrova, Krasimira; Tjønneland, Anne; Johnsen, Nina Føns; Overvad, Kim; Ramón Quirós, J.; González, Carlos A.; Molina-Montes, Esther; Sánchez, Maria José; Larrañaga, Nerea; Castaño, José María Huerta; Ardanaz, Eva; Khaw, Kay Tee; Wareham, Nick; Trichopoulou, Antonia; Karapetyan, Tina; Rafnsson, Snorri Bjorn; Palli, Domenico; Krogh, Vittorio; Tumino, Rosario; Vineis, Paolo; Bueno-De-Mesquita, H. Bas; Stattin, Pär; Johansson, Mattias; Fedirko, Veronika; Norat, Teresa; Siddiq, Afshan; Riboli, Elio; Key, Timothy J.

In: Cancer Causes and Control, Vol. 23, No. 7, 07.2012, p. 1163-1171.

Research output: Contribution to journalArticle

Travis, RC, Allen, NE, Appleby, PN, Price, A, Kaaks, R, Chang-Claude, J, Boeing, H, Aleksandrova, K, Tjønneland, A, Johnsen, NF, Overvad, K, Ramón Quirós, J, González, CA, Molina-Montes, E, Sánchez, MJ, Larrañaga, N, Castaño, JMH, Ardanaz, E, Khaw, KT, Wareham, N, Trichopoulou, A, Karapetyan, T, Rafnsson, SB, Palli, D, Krogh, V, Tumino, R, Vineis, P, Bueno-De-Mesquita, HB, Stattin, P, Johansson, M, Fedirko, V, Norat, T, Siddiq, A, Riboli, E & Key, TJ 2012, 'Prediagnostic concentrations of plasma genistein and prostate cancer risk in 1,605 men with prostate cancer and 1,697 matched control participants in EPIC', Cancer Causes and Control, vol. 23, no. 7, pp. 1163-1171. https://doi.org/10.1007/s10552-012-9985-y
Travis, Ruth C. ; Allen, Naomi E. ; Appleby, Paul N. ; Price, Alison ; Kaaks, Rudolf ; Chang-Claude, Jenny ; Boeing, Heiner ; Aleksandrova, Krasimira ; Tjønneland, Anne ; Johnsen, Nina Føns ; Overvad, Kim ; Ramón Quirós, J. ; González, Carlos A. ; Molina-Montes, Esther ; Sánchez, Maria José ; Larrañaga, Nerea ; Castaño, José María Huerta ; Ardanaz, Eva ; Khaw, Kay Tee ; Wareham, Nick ; Trichopoulou, Antonia ; Karapetyan, Tina ; Rafnsson, Snorri Bjorn ; Palli, Domenico ; Krogh, Vittorio ; Tumino, Rosario ; Vineis, Paolo ; Bueno-De-Mesquita, H. Bas ; Stattin, Pär ; Johansson, Mattias ; Fedirko, Veronika ; Norat, Teresa ; Siddiq, Afshan ; Riboli, Elio ; Key, Timothy J. / Prediagnostic concentrations of plasma genistein and prostate cancer risk in 1,605 men with prostate cancer and 1,697 matched control participants in EPIC. In: Cancer Causes and Control. 2012 ; Vol. 23, No. 7. pp. 1163-1171.
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abstract = "Purpose: Data from prospective epidemiological studies in Asian populations and from experimental studies in animals and cell lines suggest a possible protective association between dietary isoflavones and the development of prostate cancer. We examined the association between circulating concentrations of genistein and prostate cancer risk in a case-control study nested in the European Prospective Investigation into Cancer and Nutrition. Methods: Concentrations of the isoflavone genistein were measured in prediagnostic plasma samples for 1,605 prostate cancer cases and 1,697 matched control participants. Relative risks (RRs) for prostate cancer in relation to plasma concentrations of genistein were estimated by conditional logistic regression. Results: Plasma genistein concentrations were not associated with prostate cancer risk; the multivariate relative risk for men in the highest fifth of genistein compared with men in the lowest fifth was 1.00 (95 {\%} confidence interval: 0.79, 1.27; p linear trend = 0.82). There was no evidence of heterogeneity in this association by age at blood collection, country of recruitment, or cancer stage or histological grade. Conclusion: Plasma genistein concentration was not associated with prostate cancer risk in this large cohort of European men.",
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T1 - Prediagnostic concentrations of plasma genistein and prostate cancer risk in 1,605 men with prostate cancer and 1,697 matched control participants in EPIC

AU - Travis, Ruth C.

AU - Allen, Naomi E.

AU - Appleby, Paul N.

AU - Price, Alison

AU - Kaaks, Rudolf

AU - Chang-Claude, Jenny

AU - Boeing, Heiner

AU - Aleksandrova, Krasimira

AU - Tjønneland, Anne

AU - Johnsen, Nina Føns

AU - Overvad, Kim

AU - Ramón Quirós, J.

AU - González, Carlos A.

AU - Molina-Montes, Esther

AU - Sánchez, Maria José

AU - Larrañaga, Nerea

AU - Castaño, José María Huerta

AU - Ardanaz, Eva

AU - Khaw, Kay Tee

AU - Wareham, Nick

AU - Trichopoulou, Antonia

AU - Karapetyan, Tina

AU - Rafnsson, Snorri Bjorn

AU - Palli, Domenico

AU - Krogh, Vittorio

AU - Tumino, Rosario

AU - Vineis, Paolo

AU - Bueno-De-Mesquita, H. Bas

AU - Stattin, Pär

AU - Johansson, Mattias

AU - Fedirko, Veronika

AU - Norat, Teresa

AU - Siddiq, Afshan

AU - Riboli, Elio

AU - Key, Timothy J.

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