Prediagnostic intake of dairy products and dietary calcium and colorectal cancer survival-results from the EPIC cohort study

Vincent K. Dik, Neil Murphy, Peter D. Siersema, Veronika Fedirko, Mazda Jenab, So Y. Kong, Camilla P. Hansen, Kim Overvad, Anne Tjønneland, Anja Olsen, Laure Dossus, Antoine Racine, Nadia Bastide, Kuanrong Li, Tilman Kühn, Heiner Boeing, Krasimira Aleksandrova, Antonia Trichopoulou, Dimitrios Trichopoulos, Antonia BarbitsiotiDomenico Palli, Paolo Contiero, Paolo Vineis, Rosaria Tumino, Salvatore Panico, Petra H M Peeters, Elisabete Weiderpass, Guri Skeie, Anette Hjartaker, Pilar Amiano, María José Sánchez, Ana Fonseca-Nunes, Aurelio Barricarte, María Dolores Chirlaque, Maria Luisa Redondo, Karin Jirström, Jonas Manjer, Lena M. Nilsson, Maria Wennberg, Kathryn E. Bradbury, Kay Tee Khaw, Nicholas Wareham, Amanda J. Cross, Elio Riboli, H. Bas Bueno-De-Mesquita

Research output: Contribution to journalArticlepeer-review

Abstract

Background: We investigated whether prediagnostic reported intake of dairy products and dietary calcium is associated with colorectal cancer survival.

Results: The consumption of total dairy products was not statistically significantly associated with risk of colorectal cancer-specific death (adjusted HR Q4 vs. Q1, 1.17; 95% CI, 0.97-1.43) nor that of all-cause death (Q4 vs. Q1, 1.16; 95% CI, 0.98-1.36). Multivariable-adjusted HRs for colorectal cancer-specific death (Q4 vs. Q1) were 1.21 (95% CI, 0.99-1.48) for milk, 1.09 (95% CI, 0.88-1.34) for yoghurt, and 0.93 (95% CI, 0.76-1.14) for cheese. The intake of dietary calcium was not associated with the risk of colorectal cancer-specific death (adjusted HR Q4 vs. Q1, 1.01; 95% CI, 0.81-1.26) nor that of all-cause death (Q4 vs. Q1, 1.01; 95% CI, 0.84-1.21).

Methods: Data from 3, 859 subjects with colorectal cancer (42.1% male; mean age at diagnosis, 64.2 ± 8.1 years) in the European Investigation into Cancer and Nutrition cohort were analyzed. Intake of dairy products and dietary calcium was assessed at baseline (1992-2000) using validated, country-specific dietary questionnaires. Multivariable Cox regression models were used to calculateHRand corresponding 95% confidence intervals (CI) for colorectal cancer-specific death (n = 1, 028) and all-cause death (n = 1, 525) for different quartiles of intake.

Conclusions: The prediagnostic reported intake of dairy products and dietary calcium is not associated with disease-specific or all-cause risk of death in patients diagnosed with colorectal cancer.

Impact: The impact of diet on cancer survival is largely unknown. This study shows that despite its inverse association with colorectal cancer risk, the prediagnostic intake of dairy and dietary calcium does not affect colorectal cancer survival.

Original languageEnglish
Pages (from-to)1813-1823
Number of pages11
JournalCancer Epidemiology Biomarkers and Prevention
Volume23
Issue number9
DOIs
Publication statusPublished - Sep 1 2014

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

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