TY - JOUR
T1 - Prediagnostic intake of dairy products and dietary calcium and colorectal cancer survival-results from the EPIC cohort study
AU - Dik, Vincent K.
AU - Murphy, Neil
AU - Siersema, Peter D.
AU - Fedirko, Veronika
AU - Jenab, Mazda
AU - Kong, So Y.
AU - Hansen, Camilla P.
AU - Overvad, Kim
AU - Tjønneland, Anne
AU - Olsen, Anja
AU - Dossus, Laure
AU - Racine, Antoine
AU - Bastide, Nadia
AU - Li, Kuanrong
AU - Kühn, Tilman
AU - Boeing, Heiner
AU - Aleksandrova, Krasimira
AU - Trichopoulou, Antonia
AU - Trichopoulos, Dimitrios
AU - Barbitsioti, Antonia
AU - Palli, Domenico
AU - Contiero, Paolo
AU - Vineis, Paolo
AU - Tumino, Rosaria
AU - Panico, Salvatore
AU - Peeters, Petra H M
AU - Weiderpass, Elisabete
AU - Skeie, Guri
AU - Hjartaker, Anette
AU - Amiano, Pilar
AU - Sánchez, María José
AU - Fonseca-Nunes, Ana
AU - Barricarte, Aurelio
AU - Chirlaque, María Dolores
AU - Redondo, Maria Luisa
AU - Jirström, Karin
AU - Manjer, Jonas
AU - Nilsson, Lena M.
AU - Wennberg, Maria
AU - Bradbury, Kathryn E.
AU - Khaw, Kay Tee
AU - Wareham, Nicholas
AU - Cross, Amanda J.
AU - Riboli, Elio
AU - Bueno-De-Mesquita, H. Bas
PY - 2014/9/1
Y1 - 2014/9/1
N2 - Background: We investigated whether prediagnostic reported intake of dairy products and dietary calcium is associated with colorectal cancer survival.Results: The consumption of total dairy products was not statistically significantly associated with risk of colorectal cancer-specific death (adjusted HR Q4 vs. Q1, 1.17; 95% CI, 0.97-1.43) nor that of all-cause death (Q4 vs. Q1, 1.16; 95% CI, 0.98-1.36). Multivariable-adjusted HRs for colorectal cancer-specific death (Q4 vs. Q1) were 1.21 (95% CI, 0.99-1.48) for milk, 1.09 (95% CI, 0.88-1.34) for yoghurt, and 0.93 (95% CI, 0.76-1.14) for cheese. The intake of dietary calcium was not associated with the risk of colorectal cancer-specific death (adjusted HR Q4 vs. Q1, 1.01; 95% CI, 0.81-1.26) nor that of all-cause death (Q4 vs. Q1, 1.01; 95% CI, 0.84-1.21).Methods: Data from 3, 859 subjects with colorectal cancer (42.1% male; mean age at diagnosis, 64.2 ± 8.1 years) in the European Investigation into Cancer and Nutrition cohort were analyzed. Intake of dairy products and dietary calcium was assessed at baseline (1992-2000) using validated, country-specific dietary questionnaires. Multivariable Cox regression models were used to calculateHRand corresponding 95% confidence intervals (CI) for colorectal cancer-specific death (n = 1, 028) and all-cause death (n = 1, 525) for different quartiles of intake.Conclusions: The prediagnostic reported intake of dairy products and dietary calcium is not associated with disease-specific or all-cause risk of death in patients diagnosed with colorectal cancer.Impact: The impact of diet on cancer survival is largely unknown. This study shows that despite its inverse association with colorectal cancer risk, the prediagnostic intake of dairy and dietary calcium does not affect colorectal cancer survival.
AB - Background: We investigated whether prediagnostic reported intake of dairy products and dietary calcium is associated with colorectal cancer survival.Results: The consumption of total dairy products was not statistically significantly associated with risk of colorectal cancer-specific death (adjusted HR Q4 vs. Q1, 1.17; 95% CI, 0.97-1.43) nor that of all-cause death (Q4 vs. Q1, 1.16; 95% CI, 0.98-1.36). Multivariable-adjusted HRs for colorectal cancer-specific death (Q4 vs. Q1) were 1.21 (95% CI, 0.99-1.48) for milk, 1.09 (95% CI, 0.88-1.34) for yoghurt, and 0.93 (95% CI, 0.76-1.14) for cheese. The intake of dietary calcium was not associated with the risk of colorectal cancer-specific death (adjusted HR Q4 vs. Q1, 1.01; 95% CI, 0.81-1.26) nor that of all-cause death (Q4 vs. Q1, 1.01; 95% CI, 0.84-1.21).Methods: Data from 3, 859 subjects with colorectal cancer (42.1% male; mean age at diagnosis, 64.2 ± 8.1 years) in the European Investigation into Cancer and Nutrition cohort were analyzed. Intake of dairy products and dietary calcium was assessed at baseline (1992-2000) using validated, country-specific dietary questionnaires. Multivariable Cox regression models were used to calculateHRand corresponding 95% confidence intervals (CI) for colorectal cancer-specific death (n = 1, 028) and all-cause death (n = 1, 525) for different quartiles of intake.Conclusions: The prediagnostic reported intake of dairy products and dietary calcium is not associated with disease-specific or all-cause risk of death in patients diagnosed with colorectal cancer.Impact: The impact of diet on cancer survival is largely unknown. This study shows that despite its inverse association with colorectal cancer risk, the prediagnostic intake of dairy and dietary calcium does not affect colorectal cancer survival.
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U2 - 10.1158/1055-9965.EPI-14-0172
DO - 10.1158/1055-9965.EPI-14-0172
M3 - Article
C2 - 24917183
AN - SCOPUS:84907174391
VL - 23
SP - 1813
EP - 1823
JO - Cancer Epidemiology Biomarkers and Prevention
JF - Cancer Epidemiology Biomarkers and Prevention
SN - 1055-9965
IS - 9
ER -