Predictability of antihypertensive efficacy of selective β1 blockers

Massimo Volpe, Bruno Trimarco, Bruno Ricciardelli, Alberto Cuocolo, Anna Maria Veniero, Nicola De Luca, Mario Condoreili

Research output: Contribution to journalArticlepeer-review

Abstract

The possibility that hemodynamic and biohumoral factors may help predict the antihypertensive effectiveness of selective α1 blockers was investigated. The effects of 3 wk of treatment with two selective β1 blockers, metoprolol and atenolol, were observed in 54 patients with mild or moderate essential hypertension. No significant difference between the hemodynamic effects of the two drugs was found. The percent fall in systolic blood pressure induced by the two correlated strongly with the pretreatment values of the chronotropic response to isoproterenol and with the pretreatment values of cardiac output, heart rate, and plasma renin activity (PRA). There was no correlation between the decrease in systolic blood pressure induced and initial 24-hr urinary catecholamine output, total peripheral resistance, and plasma aldosterone. Percent fall in diastolic blood pressure correlated only with the pretreatment levels of PRA. Our results support the view that the hypotensive effect of β1 blockers are predictable on the basis of the pretreatment values of chronotropic response to isoproterenol, PRA, heart rate, and cardiac output.

Original languageEnglish
Pages (from-to)758-763
Number of pages6
JournalClinical Pharmacology and Therapeutics
Volume34
Issue number6
Publication statusPublished - Dec 1983

ASJC Scopus subject areas

  • Pharmacology

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