TY - JOUR
T1 - Predicting atrial fibrillation recurrence with circulating inflammatory markers in patients in sinus rhythm at high risk for atrial fibrillation
T2 - Data from the GISSI atrial fibrillation trial
AU - Masson, Serge
AU - Aleksova, Aneta
AU - Favero, Chiara
AU - Staszewsky, Lidia
AU - Bernardinangeli, Marino
AU - Belvito, Chiara
AU - Cioffi, Giovanni
AU - Sinagra, Gianfranco
AU - Mazzone, Carmine
AU - Bertocchi, Federico
AU - Vago, Tarcisio
AU - Peri, Giuseppe
AU - Cuccovillo, Ivan
AU - Masuda, Nobuhito
AU - Barlera, Simona
AU - Mantovani, Alberto
AU - Maggioni, Aldo P.
AU - Franzosi, Maria Grazia
AU - Disertori, Marcello
AU - Latini, Roberto
PY - 2010/12
Y1 - 2010/12
N2 - Background: Inflammation may play a significant role in the pathogenesis of atrial fibrillation (AF). Objectives: To examine the roles of three systemic inflammatory markers in predicting recurrent AF. Methods: The association between the plasma concentrations of high-sensitivity C reactive protein (hsCRP), interleukin-6 (IL-6) and pentraxin-3 (PTX3) with echocardiographic parameters and with the time to first recurrence of AF was tested in 382 patients with a history of AF but in sinus rhythm at randomisation, enrolled in the GISSI-AF biohumoral study. Results: Baseline PTX3 was related to left atrial, but not to left ventricular chamber volume. During one year of follow-up, 204 patients (53.1%) had a recurrent AF. There were no significant differences in baseline median [Q1-Q3] plasma concentrations of IL-6, hsCRP and PTX3 among patients with (2.11 [1.47-3.74] pg/ml, 3.30 [1.40-6.80] mg/l and 4.66 [3.27-6.97] ng/ml, respectively) or without recurrent AF (2.09 [1.37-2.90] pg/ml, p=0.182; 3.00 [1.10-6.20] mg/l, p=0.333; 5.09 [3.22-7.98] ng/ml, p=0.637). At 6 and 12 months follow-up, AF patients had significantly higher concentrations of IL-6 and PTX3 than those in sinus rhythm, and those with most recent episodes of AF had higher hsCRP. Baseline levels of IL-6, hsCRP or PTX3 were not significantly associated with a higher risk of recurrence of AF. Conclusion: In patients with a history of AF, but without significant left ventricular dysfunction or heart failure, inflammatory biomarkers may be raised but are, at best, weak predictors of the risk for first recurrence of AF.
AB - Background: Inflammation may play a significant role in the pathogenesis of atrial fibrillation (AF). Objectives: To examine the roles of three systemic inflammatory markers in predicting recurrent AF. Methods: The association between the plasma concentrations of high-sensitivity C reactive protein (hsCRP), interleukin-6 (IL-6) and pentraxin-3 (PTX3) with echocardiographic parameters and with the time to first recurrence of AF was tested in 382 patients with a history of AF but in sinus rhythm at randomisation, enrolled in the GISSI-AF biohumoral study. Results: Baseline PTX3 was related to left atrial, but not to left ventricular chamber volume. During one year of follow-up, 204 patients (53.1%) had a recurrent AF. There were no significant differences in baseline median [Q1-Q3] plasma concentrations of IL-6, hsCRP and PTX3 among patients with (2.11 [1.47-3.74] pg/ml, 3.30 [1.40-6.80] mg/l and 4.66 [3.27-6.97] ng/ml, respectively) or without recurrent AF (2.09 [1.37-2.90] pg/ml, p=0.182; 3.00 [1.10-6.20] mg/l, p=0.333; 5.09 [3.22-7.98] ng/ml, p=0.637). At 6 and 12 months follow-up, AF patients had significantly higher concentrations of IL-6 and PTX3 than those in sinus rhythm, and those with most recent episodes of AF had higher hsCRP. Baseline levels of IL-6, hsCRP or PTX3 were not significantly associated with a higher risk of recurrence of AF. Conclusion: In patients with a history of AF, but without significant left ventricular dysfunction or heart failure, inflammatory biomarkers may be raised but are, at best, weak predictors of the risk for first recurrence of AF.
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U2 - 10.1136/hrt.2009.191460
DO - 10.1136/hrt.2009.191460
M3 - Article
C2 - 20965978
AN - SCOPUS:78649903584
VL - 96
SP - 1909
EP - 1914
JO - Heart
JF - Heart
SN - 1355-6037
IS - 23
ER -