Predicting Cognitive Decline in Alzheimer Disease: Role of Platelet Amyloid Precursor Protein

Barbara Borroni; Francesca Colciaghi; Silvana Archetti; Elena Marcello; Luigi Caimi; Monica Di Luca; Alessandro Padovani

doi:10.1097/00002093-200401000-00006

Predicting Cognitive Decline in Alzheimer Disease: Role of Platelet Amyloid Precursor Protein

Barbara Borroni, Francesca Colciaghi, Silvana Archetti, Elena Marcello, Luigi Caimi, Monica Di Luca, Alessandro Padovani

Fondazione IRCCS Istituto Neurologico "C. Besta"

Research output: Contribution to journal › Article

Abstract

An altered pattern of platelet amyloid precursor protein (APP) forms, consisting of a reduced ratio of the upper (130 kDa) to the lower (110 to 106 kDa) immunoreactivity band (APPr), is associated with Alzheimer disease (AD), although in the early stages of AD this pattern shows high variability. To explore whether APPr values at baseline may predict the rate of cognitive decline, we evaluated patients with mild AD before and after 1 year of treatment with acetylcholinesterase inhibitors. Lower APPr at baseline was the only predictor of progressive cognitive decline, suggesting that this biomarker might be a useful indicator of prognosis for patients with AD.

Original language	English
Pages (from-to)	32-34
Number of pages	3
Journal	Alzheimer Disease and Associated Disorders
Volume	18
Issue number	1
DOIs	https://doi.org/10.1097/00002093-200401000-00006
Publication status	Published - Jan 2004

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Keywords

Acetylcholinesterase inhibitors
Amyloid precursor protein
Rate of cognitive decline

ASJC Scopus subject areas

Geriatrics and Gerontology
Psychiatry and Mental health
Neuroscience(all)

Cite this

Borroni, B., Colciaghi, F., Archetti, S., Marcello, E., Caimi, L., Di Luca, M., & Padovani, A. (2004). Predicting Cognitive Decline in Alzheimer Disease: Role of Platelet Amyloid Precursor Protein. Alzheimer Disease and Associated Disorders, 18(1), 32-34. https://doi.org/10.1097/00002093-200401000-00006

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10.1097/00002093-200401000-00006