Predicting Cognitive Decline in Alzheimer Disease: Role of Platelet Amyloid Precursor Protein

Barbara Borroni, Francesca Colciaghi, Silvana Archetti, Elena Marcello, Luigi Caimi, Monica Di Luca, Alessandro Padovani

Research output: Contribution to journalArticle


An altered pattern of platelet amyloid precursor protein (APP) forms, consisting of a reduced ratio of the upper (130 kDa) to the lower (110 to 106 kDa) immunoreactivity band (APPr), is associated with Alzheimer disease (AD), although in the early stages of AD this pattern shows high variability. To explore whether APPr values at baseline may predict the rate of cognitive decline, we evaluated patients with mild AD before and after 1 year of treatment with acetylcholinesterase inhibitors. Lower APPr at baseline was the only predictor of progressive cognitive decline, suggesting that this biomarker might be a useful indicator of prognosis for patients with AD.

Original languageEnglish
Pages (from-to)32-34
Number of pages3
JournalAlzheimer Disease and Associated Disorders
Issue number1
Publication statusPublished - Jan 2004



  • Acetylcholinesterase inhibitors
  • Amyloid precursor protein
  • Rate of cognitive decline

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Psychiatry and Mental health
  • Neuroscience(all)

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