Predicting disease recurrence in patients with previous unprovoked venous thromboembolism: A proposed prediction score (DASH)

A. Tosetto, A. Iorio, M. Marcucci, T. Baglin, M. Cushman, S. Eichinger, G. Palareti, D. Poli, R. C. Tait, J. Douketis

Research output: Contribution to journalArticle

Abstract

Background: In patients with unprovoked venous thromboembolism (VTE), the optimal duration of anticoagulation is anchored on estimating the risk of disease recurrence. Objectives: We aimed to develop a score that could predict the recurrence risk following a first episode of unprovoked VTE, pooling individual patient data from seven prospective studies. Methods: One thousand eight hundred and eighteen cases with unprovoked VTE treated for at least 3months with a vitamin K antagonist were available for analysis. Optimism-corrected Cox regression coefficients were used to develop a recurrence score that was subsequently internally validated by bootstrap analysis. Results: Abnormal D-dimer after stopping anticoagulation, age

Original languageEnglish
Pages (from-to)1019-1025
Number of pages7
JournalJournal of Thrombosis and Haemostasis
Volume10
Issue number6
DOIs
Publication statusPublished - Jun 2012

Keywords

  • D-dimer
  • Recurrence
  • Risk
  • Venous thrombosis

ASJC Scopus subject areas

  • Hematology

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