Predicting failure of hematopoietic stem cell mobilization before it starts: The predicted poor mobilizer (pPM) score

J Olivieri, I Attolico, R Nuccorini, SP Pascale, M Chiarucci, M Poiani, P Corradini, L Farina, G Gaidano, L Nassi, S Sica, N Piccirillo, PE Pioltelli, M Martino, T Moscato, M Pini, F Zallio, F Ciceri, S Marktel, A MengarelliP Musto, S Capria, F Merli, K Codeluppi, G Mele, F Lanza, G Specchia, D Pastore, G Milone, F Saraceni, E Di Nardo, P Perseghin, A Olivieri

Research output: Contribution to journalArticle

Abstract

Predicting mobilization failure before it starts may enable patient-tailored strategies. Although consensus criteria for predicted PM (pPM) are available, their predictive performance has never been measured on real data. We retrospectively collected and analyzed 1318 mobilization procedures performed for MM and lymphoma patients in the plerixafor era. In our sample, 180/1318 (13.7%) were PM. The score resulting from published pPM criteria had sufficient performance for predicting PM, as measured by AUC (0.67, 95%CI: 0.63-0.72). We developed a new prediction model from multivariate analysis whose score (pPM-score) resulted in better AUC (0.80, 95%CI: 0.76-0.84, p < 0001). pPM-score included as risk factors: increasing age, diagnosis of NHL, positive bone marrow biopsy or cytopenias before mobilization, previous mobilization failure, priming strategy with G-CSF alone, or without upfront plerixafor. A simplified version of pPM-score was categorized using a cut-off to maximize positive likelihood ratio (15.7, 95%CI: 9.9-24.8); specificity was 98% (95%CI: 97-98.7%), sensitivity 31.7% (95%CI: 24.9-39%); positive predictive value in our sample was 71.3% (95%CI: 60-80.8%). Simplified pPM-score can "rule in" patients at very high risk for PM before starting mobilization, allowing changes in clinical management, such as choice of alternative priming strategies, to avoid highly likely mobilization failure. © 2017 The Author(s) 2017, under exclusive licence to Macmillan Publishers Limited, part of Springer Nature.
Original languageEnglish
Pages (from-to)461-473
Number of pages13
JournalBone Marrow Transplantation
Volume53
Issue number4
DOIs
Publication statusPublished - 2018

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Hematopoietic Stem Cell Mobilization
Area Under Curve
Granulocyte Colony-Stimulating Factor
Licensure
Lymphoma
Multivariate Analysis
Bone Marrow
Biopsy
JM 3100

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Olivieri, J., Attolico, I., Nuccorini, R., Pascale, SP., Chiarucci, M., Poiani, M., ... Olivieri, A. (2018). Predicting failure of hematopoietic stem cell mobilization before it starts: The predicted poor mobilizer (pPM) score. Bone Marrow Transplantation, 53(4), 461-473. https://doi.org/10.1038/s41409-017-0051-y

Predicting failure of hematopoietic stem cell mobilization before it starts: The predicted poor mobilizer (pPM) score. / Olivieri, J; Attolico, I; Nuccorini, R; Pascale, SP; Chiarucci, M; Poiani, M; Corradini, P; Farina, L; Gaidano, G; Nassi, L; Sica, S; Piccirillo, N; Pioltelli, PE; Martino, M; Moscato, T; Pini, M; Zallio, F; Ciceri, F; Marktel, S; Mengarelli, A; Musto, P; Capria, S; Merli, F; Codeluppi, K; Mele, G; Lanza, F; Specchia, G; Pastore, D; Milone, G; Saraceni, F; Di Nardo, E; Perseghin, P; Olivieri, A.

In: Bone Marrow Transplantation, Vol. 53, No. 4, 2018, p. 461-473.

Research output: Contribution to journalArticle

Olivieri, J, Attolico, I, Nuccorini, R, Pascale, SP, Chiarucci, M, Poiani, M, Corradini, P, Farina, L, Gaidano, G, Nassi, L, Sica, S, Piccirillo, N, Pioltelli, PE, Martino, M, Moscato, T, Pini, M, Zallio, F, Ciceri, F, Marktel, S, Mengarelli, A, Musto, P, Capria, S, Merli, F, Codeluppi, K, Mele, G, Lanza, F, Specchia, G, Pastore, D, Milone, G, Saraceni, F, Di Nardo, E, Perseghin, P & Olivieri, A 2018, 'Predicting failure of hematopoietic stem cell mobilization before it starts: The predicted poor mobilizer (pPM) score', Bone Marrow Transplantation, vol. 53, no. 4, pp. 461-473. https://doi.org/10.1038/s41409-017-0051-y
Olivieri, J ; Attolico, I ; Nuccorini, R ; Pascale, SP ; Chiarucci, M ; Poiani, M ; Corradini, P ; Farina, L ; Gaidano, G ; Nassi, L ; Sica, S ; Piccirillo, N ; Pioltelli, PE ; Martino, M ; Moscato, T ; Pini, M ; Zallio, F ; Ciceri, F ; Marktel, S ; Mengarelli, A ; Musto, P ; Capria, S ; Merli, F ; Codeluppi, K ; Mele, G ; Lanza, F ; Specchia, G ; Pastore, D ; Milone, G ; Saraceni, F ; Di Nardo, E ; Perseghin, P ; Olivieri, A. / Predicting failure of hematopoietic stem cell mobilization before it starts: The predicted poor mobilizer (pPM) score. In: Bone Marrow Transplantation. 2018 ; Vol. 53, No. 4. pp. 461-473.
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T1 - Predicting failure of hematopoietic stem cell mobilization before it starts: The predicted poor mobilizer (pPM) score

AU - Olivieri, J

AU - Attolico, I

AU - Nuccorini, R

AU - Pascale, SP

AU - Chiarucci, M

AU - Poiani, M

AU - Corradini, P

AU - Farina, L

AU - Gaidano, G

AU - Nassi, L

AU - Sica, S

AU - Piccirillo, N

AU - Pioltelli, PE

AU - Martino, M

AU - Moscato, T

AU - Pini, M

AU - Zallio, F

AU - Ciceri, F

AU - Marktel, S

AU - Mengarelli, A

AU - Musto, P

AU - Capria, S

AU - Merli, F

AU - Codeluppi, K

AU - Mele, G

AU - Lanza, F

AU - Specchia, G

AU - Pastore, D

AU - Milone, G

AU - Saraceni, F

AU - Di Nardo, E

AU - Perseghin, P

AU - Olivieri, A

PY - 2018

Y1 - 2018

N2 - Predicting mobilization failure before it starts may enable patient-tailored strategies. Although consensus criteria for predicted PM (pPM) are available, their predictive performance has never been measured on real data. We retrospectively collected and analyzed 1318 mobilization procedures performed for MM and lymphoma patients in the plerixafor era. In our sample, 180/1318 (13.7%) were PM. The score resulting from published pPM criteria had sufficient performance for predicting PM, as measured by AUC (0.67, 95%CI: 0.63-0.72). We developed a new prediction model from multivariate analysis whose score (pPM-score) resulted in better AUC (0.80, 95%CI: 0.76-0.84, p < 0001). pPM-score included as risk factors: increasing age, diagnosis of NHL, positive bone marrow biopsy or cytopenias before mobilization, previous mobilization failure, priming strategy with G-CSF alone, or without upfront plerixafor. A simplified version of pPM-score was categorized using a cut-off to maximize positive likelihood ratio (15.7, 95%CI: 9.9-24.8); specificity was 98% (95%CI: 97-98.7%), sensitivity 31.7% (95%CI: 24.9-39%); positive predictive value in our sample was 71.3% (95%CI: 60-80.8%). Simplified pPM-score can "rule in" patients at very high risk for PM before starting mobilization, allowing changes in clinical management, such as choice of alternative priming strategies, to avoid highly likely mobilization failure. © 2017 The Author(s) 2017, under exclusive licence to Macmillan Publishers Limited, part of Springer Nature.

AB - Predicting mobilization failure before it starts may enable patient-tailored strategies. Although consensus criteria for predicted PM (pPM) are available, their predictive performance has never been measured on real data. We retrospectively collected and analyzed 1318 mobilization procedures performed for MM and lymphoma patients in the plerixafor era. In our sample, 180/1318 (13.7%) were PM. The score resulting from published pPM criteria had sufficient performance for predicting PM, as measured by AUC (0.67, 95%CI: 0.63-0.72). We developed a new prediction model from multivariate analysis whose score (pPM-score) resulted in better AUC (0.80, 95%CI: 0.76-0.84, p < 0001). pPM-score included as risk factors: increasing age, diagnosis of NHL, positive bone marrow biopsy or cytopenias before mobilization, previous mobilization failure, priming strategy with G-CSF alone, or without upfront plerixafor. A simplified version of pPM-score was categorized using a cut-off to maximize positive likelihood ratio (15.7, 95%CI: 9.9-24.8); specificity was 98% (95%CI: 97-98.7%), sensitivity 31.7% (95%CI: 24.9-39%); positive predictive value in our sample was 71.3% (95%CI: 60-80.8%). Simplified pPM-score can "rule in" patients at very high risk for PM before starting mobilization, allowing changes in clinical management, such as choice of alternative priming strategies, to avoid highly likely mobilization failure. © 2017 The Author(s) 2017, under exclusive licence to Macmillan Publishers Limited, part of Springer Nature.

U2 - 10.1038/s41409-017-0051-y

DO - 10.1038/s41409-017-0051-y

M3 - Article

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SP - 461

EP - 473

JO - Bone Marrow Transplantation

JF - Bone Marrow Transplantation

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