TY - JOUR
T1 - Predicting genitourinary toxicity in three-dimensional conformal radiotherapy for localized prostate cancer
T2 - A dose-volume parameters analysis of the bladder
AU - Bagalà, Paolo
AU - Ingrosso, Gianluca
AU - De Falco, Maria
AU - Petrichella, Sara
AU - D'Andrea, Marco
AU - Rago, Maria
AU - Lancia, Andrea
AU - Bruni, Claudia
AU - Ponti, Elisabetta
AU - Santoni, Riccardo
PY - 2016/4/1
Y1 - 2016/4/1
N2 - Purpose: In prostate cancer radiotherapy, the relationship between genitourinary (GU) toxicity and clinical-dosimetric parameters is debated. We report our analysis of the parameters associated with GU toxicity. Materials and Methods: Eighty-six consecutive patients treated with conformal radiotherapy for localized prostate cancer were retrospectively analyzed; the bladder was delineated both as 'whole bladder' (WB: Defined in its entirety as a solid organ) and 'inferior bladder' (IB: Corresponding to the distal part of the bladder). GU toxicity and dose-volume parameters were correlated using the point biserial correlation coefficient. The normal tissue complication probability (NTCP) cut-off volume model was fitted to toxicity data; univariate analysis between GU toxicity and clinical parameters was done. Results: Acute GU toxicity was correlated to doses higher than 80 Gy (P < 0.05) while late GU was correlated to doses higher than 77 Gy for WB and from 77.5 Gy for IB. The NTCP cut-off volume model identified for both WB and IB a bladder volume of 6 cc receiving a dose ≥77 Gy corresponding to a 50% probability of GU toxicity. At univariate analysis, acute GU toxicity was correlated with smoke (P < 0.001). Conclusion: Bladder maximal doses quantified as hotspots show a correlation to GU toxicity.
AB - Purpose: In prostate cancer radiotherapy, the relationship between genitourinary (GU) toxicity and clinical-dosimetric parameters is debated. We report our analysis of the parameters associated with GU toxicity. Materials and Methods: Eighty-six consecutive patients treated with conformal radiotherapy for localized prostate cancer were retrospectively analyzed; the bladder was delineated both as 'whole bladder' (WB: Defined in its entirety as a solid organ) and 'inferior bladder' (IB: Corresponding to the distal part of the bladder). GU toxicity and dose-volume parameters were correlated using the point biserial correlation coefficient. The normal tissue complication probability (NTCP) cut-off volume model was fitted to toxicity data; univariate analysis between GU toxicity and clinical parameters was done. Results: Acute GU toxicity was correlated to doses higher than 80 Gy (P < 0.05) while late GU was correlated to doses higher than 77 Gy for WB and from 77.5 Gy for IB. The NTCP cut-off volume model identified for both WB and IB a bladder volume of 6 cc receiving a dose ≥77 Gy corresponding to a 50% probability of GU toxicity. At univariate analysis, acute GU toxicity was correlated with smoke (P < 0.001). Conclusion: Bladder maximal doses quantified as hotspots show a correlation to GU toxicity.
KW - Bladder toxicity
KW - dose-volume histogram analysis
KW - normal tissue complication probability
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U2 - 10.4103/0973-1482.165871
DO - 10.4103/0973-1482.165871
M3 - Article
AN - SCOPUS:84980010006
VL - 12
SP - 1018
EP - 1024
JO - Journal of Cancer Research and Therapeutics
JF - Journal of Cancer Research and Therapeutics
SN - 0973-1482
IS - 2
ER -