Predicting the clinical outcome of allogeneic hematopoietic stem cell transplantation: The long and winding road toward validated immune biomarkers

A. Forcina, M. Noviello, M. R. Carbone, Chiara Bonini, Attilio Bondanza

Research output: Contribution to journalArticlepeer-review

Abstract

The clinical outcome of allogeneic hematopoietic stem cell transplantation (HSCT) is strongly influenced from the potential complications arising during the delicate phase of post-transplant immune restoration. The quantitative aspects of immune-cell repopulation after HSCT and the qualitative features their functional restitution have been extensively reported. Nevertheless, measurable immune biomarkers predicting the clinical outcome of HSCT await formal validation. The aim of this review is an appraisal of most studies published so far on the predictive value of different T and NK-cell biomarkers after HSCT with emphasis on defined thresholds endorsed by multivariate analysis.

Original languageEnglish
Article numberArticle 71
JournalFrontiers in Immunology
Volume4
Issue numberMAR
DOIs
Publication statusPublished - 2013

Keywords

  • Allogeneic hematopoietic stem cell transplantation
  • Biomarkers
  • Graft-versus-host disease
  • Immune reconstitution
  • Opportunistic infections

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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