Predicting toxicity in radiotherapy for prostate cancer

Valeria Landoni, Claudio Fiorino, Cesare Cozzarini, Giuseppe Sanguineti, Riccardo Valdagni, Tiziana Rancati

Research output: Contribution to journalArticlepeer-review


This comprehensive review addresses most organs at risk involved in planning optimization for prostate cancer. It can be considered an update of a previous educational review that was published in 2009 (Fiorino et al., 2009).The literature was reviewed based on PubMed and MEDLINE database searches (from January 2009 up to September 2015), including papers in press; for each section/subsection, key title words were used and possibly combined with other more general key-words (such as radiotherapy, dose-volume effects, NTCP, DVH, and predictive model). Publications generally dealing with toxicity without any association with dose-volume effects or correlations with clinical risk factors were disregarded, being outside the aim of the review.A focus was on external beam radiotherapy, including post-prostatectomy, with conventional fractionation or moderate hypofractionation (

Original languageEnglish
Pages (from-to)521-532
Number of pages12
JournalPhysica Medica
Issue number3
Publication statusPublished - Mar 1 2016


  • Acute and late toxicity
  • Dose-volume models
  • Prostate cancer
  • Radiotherapy

ASJC Scopus subject areas

  • Biophysics
  • Radiology Nuclear Medicine and imaging
  • Physics and Astronomy(all)


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