Prediction of clinical response to glucocorticoids in children with acute lymphoblastic leukemia

Renato Mastrangelo, Riccardo Riccardi, Serenella Corbo, Paolo Marchetti, Stefano Iacobelli

Research output: Contribution to journalArticle

Abstract

We evaluated in acute lyrnphoblastic leukemia (ALL) the feasibility of an in vivo sensitivity test of the leukemic cells to predict clinical responsiveness to glucocorticoids (GC). The results of this test were compared, in the same patients, with the results of a glucocorticoid receptor (GR) determination performed at diagnosis. We evaluated 33 children with newly diagnosed ALL. GC alone were administered at the usual dosage of 2 mg/kg/day for 3 days before polichemotherapy as in the M-IMFRA protocol. Response to GC was evaluated on the fourth day of treatment on the basis of the change in the total peripheral blast count. Although some correlation was noted between GR levels and response to GC, especially in patients with GR

Original languageEnglish
Pages (from-to)33-36
Number of pages4
JournalPediatric Hematology and Oncology
Volume1
Issue number1
DOIs
Publication statusPublished - 1984

Keywords

  • ALL== acute lymphoblastic leukemia
  • GC== glucocorticoids
  • GR== glucocorticoid receptor

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

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