Prediction of functional capacity by low-dose dobutamine stress echocardiography in chronic heart failure

R. Natali, M. Lotrionte, N. Marchese, G. Di Giannuario, S. Brugaletta, C. Pisanello, G. Comerci, M. Savino, A. Lombardo, F. Forni, C. Vigna, F. Loperfido

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Abstract

Aim. The aim of this study was to determine if low-dose dobutamine stress echocardiography (LD-DSE) is associated with functional capacity in unselected elderly patients with chronic heart failure. Methods. This was a prospective trial. Thirty five consecutive patients were included, with age ≥65 years and left ventricular dysfunction (12 ischemic), by blindly assessed LD-DSE and cardiopulmonary exercise testing (CPT). Contractile reserve was defined as a change (Δ) in wall motion score index (WMSI) ≤0.2 at peak dose dobutamine. At CPT treadmill exercise time, peak VO2, %Vo 2, and VE/VCO2 slope were determined. Preserved functional capacity was defined as percent of maximal predicted O2 consumption (%VO2) ≥80%. Baseline NT-proBNP plasma levels were assessed. Results. CPT variables were not related to clinical and baseline echocardiography characteristics but were related to WMSI (exercise time, P=0.004; peak VO2 P = 0.008; %VO2, P2, P2, respectively). Conclusion. Contractile reserve elicited at LD-DSE is associated with functional capacity in unselected elderly patients with chronic heart failure.

Original languageEnglish
Pages (from-to)277-285
Number of pages9
JournalMinerva Cardioangiologica
Volume56
Issue number3
Publication statusPublished - Jun 2008

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Keywords

  • Echocardiography, stress
  • Functional residual capacity
  • Heart failure

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Natali, R., Lotrionte, M., Marchese, N., Di Giannuario, G., Brugaletta, S., Pisanello, C., Comerci, G., Savino, M., Lombardo, A., Forni, F., Vigna, C., & Loperfido, F. (2008). Prediction of functional capacity by low-dose dobutamine stress echocardiography in chronic heart failure. Minerva Cardioangiologica, 56(3), 277-285.