TY - JOUR
T1 - Prediction of functional capacity by low-dose dobutamine stress echocardiography in chronic heart failure
AU - Natali, R.
AU - Lotrionte, M.
AU - Marchese, N.
AU - Di Giannuario, G.
AU - Brugaletta, S.
AU - Pisanello, C.
AU - Comerci, G.
AU - Savino, M.
AU - Lombardo, A.
AU - Forni, F.
AU - Vigna, C.
AU - Loperfido, F.
PY - 2008/6
Y1 - 2008/6
N2 - Aim. The aim of this study was to determine if low-dose dobutamine stress echocardiography (LD-DSE) is associated with functional capacity in unselected elderly patients with chronic heart failure. Methods. This was a prospective trial. Thirty five consecutive patients were included, with age ≥65 years and left ventricular dysfunction (12 ischemic), by blindly assessed LD-DSE and cardiopulmonary exercise testing (CPT). Contractile reserve was defined as a change (Δ) in wall motion score index (WMSI) ≤0.2 at peak dose dobutamine. At CPT treadmill exercise time, peak VO2, %Vo 2, and VE/VCO2 slope were determined. Preserved functional capacity was defined as percent of maximal predicted O2 consumption (%VO2) ≥80%. Baseline NT-proBNP plasma levels were assessed. Results. CPT variables were not related to clinical and baseline echocardiography characteristics but were related to WMSI (exercise time, P=0.004; peak VO2 P = 0.008; %VO2, P2, P2, respectively). Conclusion. Contractile reserve elicited at LD-DSE is associated with functional capacity in unselected elderly patients with chronic heart failure.
AB - Aim. The aim of this study was to determine if low-dose dobutamine stress echocardiography (LD-DSE) is associated with functional capacity in unselected elderly patients with chronic heart failure. Methods. This was a prospective trial. Thirty five consecutive patients were included, with age ≥65 years and left ventricular dysfunction (12 ischemic), by blindly assessed LD-DSE and cardiopulmonary exercise testing (CPT). Contractile reserve was defined as a change (Δ) in wall motion score index (WMSI) ≤0.2 at peak dose dobutamine. At CPT treadmill exercise time, peak VO2, %Vo 2, and VE/VCO2 slope were determined. Preserved functional capacity was defined as percent of maximal predicted O2 consumption (%VO2) ≥80%. Baseline NT-proBNP plasma levels were assessed. Results. CPT variables were not related to clinical and baseline echocardiography characteristics but were related to WMSI (exercise time, P=0.004; peak VO2 P = 0.008; %VO2, P2, P2, respectively). Conclusion. Contractile reserve elicited at LD-DSE is associated with functional capacity in unselected elderly patients with chronic heart failure.
KW - Echocardiography, stress
KW - Functional residual capacity
KW - Heart failure
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M3 - Article
C2 - 18509288
AN - SCOPUS:46749108817
VL - 56
SP - 277
EP - 285
JO - Minerva Cardioangiologica
JF - Minerva Cardioangiologica
SN - 0026-4725
IS - 3
ER -