Prediction of successful defibrillation in human victims of out-of-hospital cardiac arrest: A retrospective electrocardiographic analysis

G. Ristagno, A. Gullo, G. Berlot, U. Lucangelo, F. Geheb, J. Bisera

Research output: Contribution to journalArticle


In the present study we sought to examine the efficacy of an electrocardiographic parameter, 'amplitude spectrum area' (AMSA), to predict the likelihood that any one electrical shock would restore a perfusing rhythm during cardiopulmonary resuscitation in human victims of out-of-hospital cardiac arrest. AMSA analysis is not invalidated by artefacts produced by chest compression and thus it can be performed during CPR, avoiding detrimental interruptions of chest compression and ventilation. We hypothesised that a threshold value of AMSA could be identified as an indicator of successful defibrillation in human victims of cardiac arrest. Analysis was performed on a database of electrocardiographic records, representing lead 2 equivalent recordings from automated external defibrillators including 210 defibrillation attempts from 90 victims of out-of-hospital cardiac arrest. A 4.1 second interval of ventricular fibrillation or ventricular tachycardia, recorded immediately preceding the delivery of the shock, was analysed using the AMSA algorithm. AMSA represents a numerical value based on the sum of the magnitude of the weighted frequency spectrum between two and 48 Hz. AMSA values were significantly greater in successful defibrillation (restoration of a perfusing rhythm), compared to unsuccessful defibrillation (P

Original languageEnglish
Pages (from-to)46-50
Number of pages5
JournalAnaesthesia and Intensive Care
Issue number1
Publication statusPublished - Jan 2008



  • Amplitude spectrum area
  • Defibrillation
  • ECG
  • Ventricular fibrillation

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

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