Predictive factors of downstaging of hepatocellular carcinoma beyond the milan criteria treated with intra-arterial therapies

Valentina Bova, Roberto Miraglia, Luigi Maruzzelli, Giovanni Battista Vizzini, Angelo Luca

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: This study was designed to analyze the clinical results in patients suitable for liver transplantation with hepatocellular carcinoma (HCC) who exceeded Milan criteria, which underwent intra-arterial therapies (IAT), to determine predictive factors of successful downstaging. Methods: A total of 277 consecutive patients with cirrhosis and HCC were treated by IAT (transarterial oily chemoembolization, transarterial chemoembolization, transarterial embolization) in a single center. Eighty patients exceed the Milan criteria. Patients with infiltrative HCC, hypovascular HCC, and portal vein thrombosis were excluded, with a final study population of 48 patients. Tumor response to IAT was evaluated with CT and/or MRI according to modified RECIST criteria. Successful downstaging was defined as a reduction in the number and size of viable tumors to within the Milan criteria, and serum alpha-fetoprotein (AFP)

Original languageEnglish
Pages (from-to)433-439
Number of pages7
JournalCardioVascular and Interventional Radiology
Volume36
Issue number2
DOIs
Publication statusPublished - Apr 2013

Keywords

  • Chemoembolization
  • Hepatocellular carcinoma (HCC)
  • Liver/hepatic

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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