Predictive factors of histologic response to primary chemotherapy in patients with ewing sarcoma

Stefano Ferrari, Franco Bertoni, Emanuela Palmerini, Costantino Errani, Patrizia Bacchini, Elettra Pignotti, Mario Mercuri, Alessandra Longhi, Marilena Cesari, Piero Picci

Research output: Contribution to journalArticlepeer-review

Abstract

A correlation between chemotherapy-induced necrosis and prognosis has been reported in Ewing sarcoma. To identify factors influencing histologic response data from 122 patients with Ewing sarcoma surgically treated were reviewed. Primary chemotherapy was based on vincristine, doxorubicin, cyclophosphamide, ifosfamide, actinomycin-D, and etoposide. Patients with complete necrosis or only scattered foci of viable tumor cells were good responders (GRs), the remaining patients poor responders (PRs). Age, sex, site and size of the tumor, fever at diagnosis, and lactate dehydrogenase level were clinical variables investigated. Mean age was 13.3±6 in GR and 18.1±9 in PR (P18 years (P=0.003). Female were more likely to achieve a GR (F 64% vs. M 42%, P

Original languageEnglish
Pages (from-to)364-368
Number of pages5
JournalJournal of Pediatric Hematology/Oncology
Volume29
Issue number6
DOIs
Publication statusPublished - Jun 2007

Keywords

  • Age
  • Chemotherapy
  • Ewing sarcoma
  • Necrosis
  • Sex

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Pediatrics, Perinatology, and Child Health

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