Predictive factors of neutralizing antibodies development in relapsing-remitting multiple sclerosis patients on interferon Beta-1b therapy

R. Lanzillo, G. Orefice, A. Prinster, G. Ventrella, R. Liuzzi, V. Scarano, C. Florio, G. Vacca, A. Brunetti, B. Alfano, V. Brescia Morra, V. Bonavita

Research output: Contribution to journalArticlepeer-review

Abstract

The identification of predictive factors of NAbs development might have a relevant impact on clinical practice. Our objective is to look after predictive factors of NAbs development in MS IFN Beta-1b-treated patients. Database was screened for patients on IFN Beta-1b treatment with an Expanded Disability Status Scale (EDSS) at a baseline between 1 and 3.5, disease duration shorter than 15 years, and NAbs analysis performed every 6 months. The NAbs positive status was analysed in relation to baseline clinical, neuropsychological and brain imaging measures. Forty-nine patients were included. Sixteen patients had become NAbs positive at some point on IFN therapy (35%). NAbs producers differed from not producers for higher incidence of cognitive deficit and higher lesion load (OR = 5.0 and 5.6, respectively). Our study suggests that NAbs development might be a marker of a more aggressive disease and that worse outcome in NAbs producers might be biased by baseline condition.

Original languageEnglish
Pages (from-to)287-292
Number of pages6
JournalNeurological Sciences
Volume32
Issue number2
DOIs
Publication statusPublished - Apr 2011

Keywords

  • Beta interferon
  • Cognitive deficit
  • Multiple sclerosis
  • Neutralizing antibodies
  • Predictive factors

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Dermatology

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