Predictive factors of non-sentinel lymph node involvement in patients with invasive breast cancer and sentinel node micrometastases

Daniele Friedman, Marco Gipponi, Federica Murelli, Paolo Meszaros, Nicola Solari, Michela Massa, Francesca Depaoli, Paola Baccini, Franca Carli, Maurizio Gallo, Ferdinando Cafiero

Research output: Contribution to journalArticlepeer-review

Abstract

Patient-related, tumor-related, and sentinel node (SN)-related factors have been identified with the aim of predicting non-SN status in patients with SN micrometastases. According to our previous experience, primary tumor size (p=0.005) and the presence of lymphovascular invasion (LVI) (p=0.000) significantly predicted non-SN status in patients with SN micrometastasis; moreover, non-SN metastases were never detected in patients with pT1a-1b, G1, and no LVI. A prospective assessment was undertaken in a validation set of 126 patients to confirm these findings. Univariate analysis indicated that primary tumor size (p=0.05), Scarff-Bloom-Richardson (SBR) grade (p=0.008), LVI (p=0.001), and the number of mitoses/mm2 (p=0.01) were significant predictors of non-SN status. By logistic regression analysis, tumor size (p=0.03), LVI (p=0.001), grade (p=0.003) and the number of mitoses/mm 2 (p=0.01) were the only variables remaining in the model. Three subsets of patients were identified: i) 18.3% of patients (pT1, G1, and no LVI) had tumor-negative non-SN (no risk group); ii) 37.3% of patients (number of mitoses/mm2

Original languageEnglish
Pages (from-to)4509-4514
Number of pages6
JournalAnticancer Research
Volume33
Issue number10
Publication statusPublished - Oct 2013

Keywords

  • Breast cancer staging
  • Micrometastases
  • Sentinel lymph node

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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