TY - JOUR
T1 - Predictive factors of non-sentinel lymph node involvement in patients with invasive breast cancer and sentinel node micrometastases
AU - Friedman, Daniele
AU - Gipponi, Marco
AU - Murelli, Federica
AU - Meszaros, Paolo
AU - Solari, Nicola
AU - Massa, Michela
AU - Depaoli, Francesca
AU - Baccini, Paola
AU - Carli, Franca
AU - Gallo, Maurizio
AU - Cafiero, Ferdinando
PY - 2013/10
Y1 - 2013/10
N2 - Patient-related, tumor-related, and sentinel node (SN)-related factors have been identified with the aim of predicting non-SN status in patients with SN micrometastases. According to our previous experience, primary tumor size (p=0.005) and the presence of lymphovascular invasion (LVI) (p=0.000) significantly predicted non-SN status in patients with SN micrometastasis; moreover, non-SN metastases were never detected in patients with pT1a-1b, G1, and no LVI. A prospective assessment was undertaken in a validation set of 126 patients to confirm these findings. Univariate analysis indicated that primary tumor size (p=0.05), Scarff-Bloom-Richardson (SBR) grade (p=0.008), LVI (p=0.001), and the number of mitoses/mm2 (p=0.01) were significant predictors of non-SN status. By logistic regression analysis, tumor size (p=0.03), LVI (p=0.001), grade (p=0.003) and the number of mitoses/mm 2 (p=0.01) were the only variables remaining in the model. Three subsets of patients were identified: i) 18.3% of patients (pT1, G1, and no LVI) had tumor-negative non-SN (no risk group); ii) 37.3% of patients (number of mitoses/mm2
AB - Patient-related, tumor-related, and sentinel node (SN)-related factors have been identified with the aim of predicting non-SN status in patients with SN micrometastases. According to our previous experience, primary tumor size (p=0.005) and the presence of lymphovascular invasion (LVI) (p=0.000) significantly predicted non-SN status in patients with SN micrometastasis; moreover, non-SN metastases were never detected in patients with pT1a-1b, G1, and no LVI. A prospective assessment was undertaken in a validation set of 126 patients to confirm these findings. Univariate analysis indicated that primary tumor size (p=0.05), Scarff-Bloom-Richardson (SBR) grade (p=0.008), LVI (p=0.001), and the number of mitoses/mm2 (p=0.01) were significant predictors of non-SN status. By logistic regression analysis, tumor size (p=0.03), LVI (p=0.001), grade (p=0.003) and the number of mitoses/mm 2 (p=0.01) were the only variables remaining in the model. Three subsets of patients were identified: i) 18.3% of patients (pT1, G1, and no LVI) had tumor-negative non-SN (no risk group); ii) 37.3% of patients (number of mitoses/mm2
KW - Breast cancer staging
KW - Micrometastases
KW - Sentinel lymph node
UR - http://www.scopus.com/inward/record.url?scp=84891355824&partnerID=8YFLogxK
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M3 - Article
C2 - 24123023
AN - SCOPUS:84891355824
VL - 33
SP - 4509
EP - 4514
JO - Anticancer Research
JF - Anticancer Research
SN - 0250-7005
IS - 10
ER -