Predictive factors of recurrence in patients with early-stage epithelial ovarian cancer

Antonino Ditto, Umberto Leone Roberti Maggiore, Giorgio Bogani, Fabio Martinelli, Valentina Chiappa, Maria Teresa Evangelista, Viola Liberale, Simone Ferrero, Francesco Raspagliesi

Research output: Contribution to journalArticle

Abstract

Objective: To identify predictive factors of recurrence and survival in patients with early-stage epithelial ovarian cancer (eEOC). Methods: We retrospectively searched the medical records of all women undergoing optimal surgical staging for eEOC (stage I–II) at the National Cancer Institute of Milan, Italy, between January 1, 1974, and December 31, 2014. Results: During the study period, 429 patients underwent primary surgery followed by either adjuvant chemotherapy or observation alone for apparent eEOC. In multivariable analysis, International Federation for Gynecology and Obstetrics (FIGO) stage greater than 1 (hazard ratio [HR] 2.49, 95% CI 1.24–4.99) was the only prognostic factor for lower disease-free survival. Multivariate analysis showed that age at diagnosis (HR 1.68, 95% CI 1.14–2.47) and stage (HR 2.29, 95% CI 1.01–6.39) were independent predictive factors for poorer overall survival (OS). Conclusions: FIGO stage is the most important prognostic factor for recurrence and survival in patients with eEOC. Furthermore, age at diagnosis was identified as a factor that negatively influenced OS. Our data for oncologic outcomes are similar to those reported in previous studies.

Original languageEnglish
Pages (from-to)28-33
Number of pages6
JournalInternational Journal of Gynecology and Obstetrics
Volume145
Issue number1
DOIs
Publication statusPublished - Apr 1 2019

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Recurrence
Survival
Gynecology
Obstetrics
National Cancer Institute (U.S.)
Adjuvant Chemotherapy
Italy
Disease-Free Survival
Medical Records
Multivariate Analysis
Observation
Ovarian epithelial cancer

Keywords

  • Age
  • Early stage
  • FIGO
  • Ovarian cancer
  • Predictive factors
  • Surgery

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

Predictive factors of recurrence in patients with early-stage epithelial ovarian cancer. / Ditto, Antonino; Leone Roberti Maggiore, Umberto; Bogani, Giorgio; Martinelli, Fabio; Chiappa, Valentina; Evangelista, Maria Teresa; Liberale, Viola; Ferrero, Simone; Raspagliesi, Francesco.

In: International Journal of Gynecology and Obstetrics, Vol. 145, No. 1, 01.04.2019, p. 28-33.

Research output: Contribution to journalArticle

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AU - Bogani, Giorgio

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AU - Chiappa, Valentina

AU - Evangelista, Maria Teresa

AU - Liberale, Viola

AU - Ferrero, Simone

AU - Raspagliesi, Francesco

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