Predictive factors to targeted treatment in gastrointestinal carcinomas

Nicola Silvestris, Ilaria Marech, Anna Elisabetta Brunetti, Amalia Azzariti, Gianmauro Numico, Giuseppe Cicero, Sabina Delcuratolo, Raffaele De Luca, Claudia Burz, Vito Lorusso

Research output: Contribution to journalArticle

Abstract

Most cancers are traditionally treated with either chemotherapeutic agents, radiotherapy, or both. Identification of specific molecular characteristics of tumors and the advent of molecular-targeted drugs not only enhance the efficacy but also decrease the toxicity of treatment. These new therapies may target pathways critical to tumor development or specific driver mutations in cancer cells. This understanding of the molecular pathways of cancer cells has led to the ability to predict cancer development, behaviour and prognosis, as well as response or resistance to current therapeutic agents. As a result, pathologic analyses play a vital role in the detection of cancer biomarkers, which are important not only in the diagnosis of cancers but also in the selection of appropriate therapeutic agents and in the development of new targeted therapies.

Original languageEnglish
Pages (from-to)151-162
Number of pages12
JournalCancer Biomarkers
Volume14
Issue number2-3
DOIs
Publication statusPublished - 2014

Keywords

  • EGFR
  • Gastrointestinal cancer
  • HER2
  • targeted therapy
  • VEGF

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Genetics

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