Predictive markers of pre-eclampsia in hypertensive disorders of pregnancy

D. M. Paternoster, A. Stella, M. Mussap, M. Plebani, G. Gambaro, P. V. Grella

Research output: Contribution to journalArticle


Objective: The aim of this work is to assess the most widespread methods currently proposed and two new markers for predicting the development of pre-eclampsia in pregnant women with hypertension. Methods: The study involved 212 pregnant Caucasian women: 104 normotensive, 68 pregnancy-induced hypertensive and 40 chronic hypertensive. Blood and urine were sampled between 28 and 30 weeks gestation. All 108 hypertensive pregnant women, at the time of sampling, demonstrated proteinuria below 0.3 g/24 h. The following laboratory tests were performed: fibronectin, antithrombin-III, α-1-microglobulin, U-N-acetyl-β-glucosaminidase, uric acid and albumin excretion rate. Student's t-test, discriminant analysis and χ2 (chi-square) test were used as statistical methods. A P value less than 0.05 was considered significant. Results: After discriminating analysis, only three of the six variables analyzed were able to discriminate patients who would develop pre-eclampsia from the remaining hypertensive pregnant women: microalbuminuria, uric acid and fibronectin (χ2=29.122, P

Original languageEnglish
Pages (from-to)237-243
Number of pages7
JournalInternational Journal of Gynecology and Obstetrics
Issue number3
Publication statusPublished - Sep 1 1999


  • Microalbuminuria
  • Pre-eclampsia
  • Predictive markers
  • U-α-1-microglobulin
  • Uric acid

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

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    Paternoster, D. M., Stella, A., Mussap, M., Plebani, M., Gambaro, G., & Grella, P. V. (1999). Predictive markers of pre-eclampsia in hypertensive disorders of pregnancy. International Journal of Gynecology and Obstetrics, 66(3), 237-243.