TY - JOUR
T1 - Predictive nomograms for oral tongue squamous cell carcinoma applying the American Joint Committee on Cancer/Union Internationale Contre le Cancer 8th edition staging system
AU - Balasubramanian, Deepak
AU - Subramaniam, Narayana
AU - Missale, Francesco
AU - Marchi, Filippo
AU - Dokhe, Yogesh
AU - Vijayan, Smitha
AU - Nambiar, Ajit
AU - Mattavelli, Davide
AU - Calza, Stefano
AU - Bresciani, Lorenzo
AU - Piazza, Cesare
AU - Nicolai, Piero
AU - Peretti, Giorgio
AU - Thankappan, Krishnakumar
AU - Iyer, Subramania
N1 - Publisher Copyright:
© 2021 Wiley Periodicals LLC
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021
Y1 - 2021
N2 - Background: Nomograms applying the 8th edition of the TNM staging system aimed at predicting overall (OS), disease-specific (DSS), locoregional recurrence-free (LRRFS) and distant recurrence-free survivals (DRFS) for oral tongue squamous cell carcinoma (OTSCC) are still lacking. Methods: A training cohort of 438 patients with OTSCC was retrospectively enrolled from a single institution. An external validation set of 287 patients was retrieved from two independent institutions. Results: Internal validation of the multivariable models for OS, DSS, DRFS and LRRFS showed a good calibration and discrimination results with optimism-corrected c-indices of 0.74, 0.75, 0.77 and 0.70, respectively. The external validation confirmed the good performance of OS, DSS and DRFS models (c-index 0.73 and 0.77, and 0.73, respectively) and a fair performance of the LRRFS model (c-index 0.58). Conclusions: The nomograms herein presented can be implemented as useful tools for prediction of OS, DSS, DRFS and LRRFS in OTSCC.
AB - Background: Nomograms applying the 8th edition of the TNM staging system aimed at predicting overall (OS), disease-specific (DSS), locoregional recurrence-free (LRRFS) and distant recurrence-free survivals (DRFS) for oral tongue squamous cell carcinoma (OTSCC) are still lacking. Methods: A training cohort of 438 patients with OTSCC was retrospectively enrolled from a single institution. An external validation set of 287 patients was retrieved from two independent institutions. Results: Internal validation of the multivariable models for OS, DSS, DRFS and LRRFS showed a good calibration and discrimination results with optimism-corrected c-indices of 0.74, 0.75, 0.77 and 0.70, respectively. The external validation confirmed the good performance of OS, DSS and DRFS models (c-index 0.73 and 0.77, and 0.73, respectively) and a fair performance of the LRRFS model (c-index 0.58). Conclusions: The nomograms herein presented can be implemented as useful tools for prediction of OS, DSS, DRFS and LRRFS in OTSCC.
KW - nomogram
KW - oral cancer
KW - prognostication
KW - squamous cell carcinoma
KW - tongue cancer
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U2 - 10.1002/hed.26554
DO - 10.1002/hed.26554
M3 - Article
AN - SCOPUS:85100161809
VL - 43
SP - 1043
EP - 1055
JO - Head and Neck Surgery
JF - Head and Neck Surgery
SN - 1043-3074
ER -