Predictive, protective, orphan autoantibodies: The example of anti-phospholipid antibodies

Pier Luigi Meroni, Yehuda Shoenfeld

Research output: Contribution to journalArticlepeer-review


Anti-phospholipid antibodies (aPL) are one of the most recent examples of autoantibodies that can appear even long time before any clinical manifestation can be associated with them. There is a general agreement that they may represent a strong risk factor for recurrent thrombosis and/or fetal losses. Anti-phospholipid antibodies represent a necessary but not sufficient factor (first hit) for thrombosis, and require additional triggering factors (second hit) to disclose the thrombogenic activity. Several factors may affect the predictive value of aPL, including titre, immunoglobulin isotype, fine antigenic specificity and affinity binding activity. Their careful evaluation is suggested in order to characterize the true predictive value of aPL.

Original languageEnglish
Pages (from-to)585-587
Number of pages3
JournalAutoimmunity Reviews
Issue number8
Publication statusPublished - Sep 2008


  • Anti-phospholipid antibodies
  • Autoantibodies
  • Predictive value

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy


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