Predictive role of ERCC1 expression in head and neck squamous cell carcinoma patients treated with surgery and adjuvant cisplatin-based chemoradiation

Marco Ciaparrone, Orietta Caspiani, Giulio Bicciolo, Diego Signorelli, Ilaria Simonelli, Luca De Campora, Giorgio Mazzarella, Antonella Mecozzi, Curzio Pianelli, Angelo Camaioni, Piera Catalano, Patrizio Pasqualetti, Alfredo Fabiano, Marco Radici, Luca Marmiroli, Domenico Cristiano Corsi

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: ERCC1 (excision repair cross-complementation group 1) expression predicts survival in patients with locally advanced head and neck squamous cell carcinoma (HNSCC) treated with chemoradiation. In order to evaluate the predictive role in the adjuvant setting, we investigated ERCC1 expression in radically resected HNSCC patients who underwent surgery and cisplatin chemoradiation. Methods: ERCC1 expression levels were determined by immunohistochemistry in primary tumor tissues from 48 patients with stage III-IV cancers. The median follow-up was 38.5 months (range: 5-121). Results: High ERCC1 expression was observed in 36 (75%) patients. Univariate analysis showed that patients with high levels of ERCC1 had significantly worse disease-free survival and overall survival (OS) than patients with low levels (HR = 7.15; 95% CI, 1.68-30.35; p = 0.008 and HR = 9.90; 95% CI, 1.33-73.96; p = 0.025, respectively). In the multivariate analysis, high ERCC1 expression (HR = 7.36; 95% CI, 1.72-31.4; p = 0.007) together with high-risk category (HR = 2.69; 95% CI, 1.01-7.18; p = 0.048) were the best predictors for relapse. High ERCC1 expression was the only unfavorable independent determinant for OS (HR = 9.53; 95% CI, 1.27-71.35; p = 0.028). Conclusions: This investigation suggests that ERCC1 expression might be useful to predict prognosis in radically resected HNSCC patients treated with surgery and chemoradiation.

Original languageEnglish
Pages (from-to)227-234
Number of pages8
JournalOncology
Volume89
DOIs
Publication statusPublished - Sep 18 2015

Keywords

  • Adjuvant concurrent chemoradiation
  • Cisplatin
  • ERCC1
  • Head and neck cancer
  • Squamous cell carcinoma

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Medicine(all)

Fingerprint Dive into the research topics of 'Predictive role of ERCC1 expression in head and neck squamous cell carcinoma patients treated with surgery and adjuvant cisplatin-based chemoradiation'. Together they form a unique fingerprint.

Cite this