Predictive role of host constitutive variants in neoadjuvant therapy of esophageal cancer

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Chemoradiotherapy followed by surgery is at present the standard therapeutic approach for esophageal cancer (EC) in patients with resectable tumor. However, response to neoadjuvant therapy is characterized by a strong interpatient variability, and the identification of markers predictive of outcome is mandatory. In this review, taking into account the currently available literature, we report the impact that host genetic variables can have on EC neoadjuvant therapy. We mainly focused on the gene variants involved in the pharmacokinetics and pharmacodynamics of the common chemotherapeutic drugs used to treat EC patients, commented on the weakness of the present knowledge, and discussed the future strategies to achieve a more personalized and effective EC treatment.

Original languageEnglish
Pages (from-to)805-820
Number of pages16
Issue number7
Publication statusPublished - May 1 2016


  • esophageal cancer
  • neoadjuvant chemotherapy
  • pharmacogenetics
  • polymorphism
  • predictive marker
  • therapy outcome

ASJC Scopus subject areas

  • Pharmacology
  • Genetics
  • Molecular Medicine

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