Predictive role of telomerase activity in the clinical outcome of patients with benign lesions of the uterine cervix or CIN

Sara Bravaccini, Andrea Amadori, Emanuela Scarpi, Maria Maddalena Tumedei, Wainer Zoli, Rosella Silvestrini

Research output: Contribution to journalArticlepeer-review

Abstract

Telomerase, a fundamental marker of neoplastic transformation, is widely expressed in both premalignant intraepithelial lesions and in most malignant lesions of the uterine cervix. We determined telomerase activity (TA) in uterine cervix by Repeat Amplification Protocol (TRAP) in a series of 62 cases, 44 with benign diseases (inflammation and/or metaplasia and/or acanthosis) and 18 with cervical intraepithelial neoplasia (CIN). No significant differences in TA were observed between benign lesions (median AEU value 36, range 0-119) and CIN (median AEU value 30, range 0-65). Conversely, TA was significantly higher in subjects who showed CIN evolution (65 range 45-119) than in disease-free individuals (34 range 0-95, ρ = 0.017) and in 1 patient with a CIN2 lesion who relapsed after 5 years. Our results suggest that TA of the uterine cervix is capable of predicting CIN evolution or relapse, thus indicating its potential usefulness as a prognostic marker in clinical surveillance programs.

Original languageEnglish
Pages (from-to)377-380
Number of pages4
JournalAnalytical Cellular Pathology
Volume35
Issue number5-6
DOIs
Publication statusPublished - 2012

Keywords

  • Cervical dysplasia
  • clinical outcome
  • telomerase activity

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Medicine
  • Pathology and Forensic Medicine
  • Cell Biology

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