Predictive value for thrombotic disease of plasminogen activator inhibitor-1 plasma levels

Domenico Prisco, Elena Chiarantini, Maria Boddi, Carlo Rostagno, Andrea Colella, Gian Franco Gensini

Research output: Contribution to journalArticlepeer-review

Abstract

Plasminogen activator inhibitor-1 plays a major role in the fibrinolytic system as the main physiological inhibitor of both tissue-type and urinary-type plasminogen activators. The inhibitor is present in plasma in small amounts and derives mainly from endothelial cells. Positive correlations have been reported between plasma levels and different parameters, such as serum triglycerides, insulin plasma levels and body mass index. Moreover, high plasma inhibitor concentrations have been observed in different disease states, but it must be stressed that plasminogen activator inhibitor-1 behaves as an acute-phase reactant and measurement of plasma levels is not significant in the acute phase of the disease. A possible predictive value of inhibitor levels for thrombotic events such as deep vein thrombosis and ischemic heart disease has been studied. On the basis of available studies, the predictive value is not clear for venous thrombosis, whereas plasminogen activator inhibitor-1 levels can predict some coronary events, at least in subgroups of young patients with a first myocardial infarction. It remains to be established if treatments able to reduce plasma inhibitor levels lead to a decrease in the risk of thromboembolic events.

Original languageEnglish
Pages (from-to)78-82
Number of pages5
JournalInternational Journal of Clinical & Laboratory Research
Volume23
Issue number1-4
DOIs
Publication statusPublished - Dec 1993

Keywords

  • Deep vein thrombosis
  • Fibrinolysis
  • Ischemic heart disease
  • Plasminogen activator inhibitor-1
  • Predictive value

ASJC Scopus subject areas

  • Clinical Biochemistry

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