Abstract
Sixteen outpatients (mean age ± SD 50.18 ± 11.55 years; 11 females and 5 males) affected by major depression without melancholia (DSM-IV) were included in the study. The control group consisted of 11 healthy volunteers (mean age ± SD 39.90 ± 13.39 years; 2 females and 9 males). Patients were treated with fluvoxamine (FVX) 100-300 mg daily. Clinical assessment was performed using the Hamilton Rating Scales for Anxiety and Depression (HRS-A; HRS-D) and the Clinical Global Impression Scale (CGI) at basal time (T0), after 4 weeks and after 8 weeks (T8). Plasma and platelet amino acid levels were determined at T0 in all the subjects and also at T8 in depressed patients. A significant clinical improvement was observed in depressed patients according to the HRS-A (p = 0.004), HRS-D (p = 0.008) and CGI (p = 0.002). A negative correlation (r = -0.53, p = 0.049) was found between platelet levels of valine and HRS-D improvement rate. Patients showed significantly higher tyrosine/large neutral amino acids (LNAAs) and lower tryptophan/LNAAs, ratios which could represent an index of good response to a serotonergic drug like FVX.
| Original language | English |
|---|---|
| Pages (from-to) | 134-138 |
| Number of pages | 5 |
| Journal | Neuropsychobiology |
| Volume | 44 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2001 |
Fingerprint
Keywords
- Amino acids
- Fluvoxamine
- Major depression
ASJC Scopus subject areas
- Psychiatry and Mental health
- Neuroscience(all)
- Psychology(all)
Cite this
Predictive value of amino acids in the treatment of major depression with fluvoxamine. / Mauri, Massimo C.; Boscati, Luigi; Volonteri, Lucia S.; Scalvini, Marta E.; Steinhilber, C. P C; Laini, Valerio; Zamberlan, Federica.
In: Neuropsychobiology, Vol. 44, No. 3, 2001, p. 134-138.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Predictive value of amino acids in the treatment of major depression with fluvoxamine
AU - Mauri, Massimo C.
AU - Boscati, Luigi
AU - Volonteri, Lucia S.
AU - Scalvini, Marta E.
AU - Steinhilber, C. P C
AU - Laini, Valerio
AU - Zamberlan, Federica
PY - 2001
Y1 - 2001
N2 - Sixteen outpatients (mean age ± SD 50.18 ± 11.55 years; 11 females and 5 males) affected by major depression without melancholia (DSM-IV) were included in the study. The control group consisted of 11 healthy volunteers (mean age ± SD 39.90 ± 13.39 years; 2 females and 9 males). Patients were treated with fluvoxamine (FVX) 100-300 mg daily. Clinical assessment was performed using the Hamilton Rating Scales for Anxiety and Depression (HRS-A; HRS-D) and the Clinical Global Impression Scale (CGI) at basal time (T0), after 4 weeks and after 8 weeks (T8). Plasma and platelet amino acid levels were determined at T0 in all the subjects and also at T8 in depressed patients. A significant clinical improvement was observed in depressed patients according to the HRS-A (p = 0.004), HRS-D (p = 0.008) and CGI (p = 0.002). A negative correlation (r = -0.53, p = 0.049) was found between platelet levels of valine and HRS-D improvement rate. Patients showed significantly higher tyrosine/large neutral amino acids (LNAAs) and lower tryptophan/LNAAs, ratios which could represent an index of good response to a serotonergic drug like FVX.
AB - Sixteen outpatients (mean age ± SD 50.18 ± 11.55 years; 11 females and 5 males) affected by major depression without melancholia (DSM-IV) were included in the study. The control group consisted of 11 healthy volunteers (mean age ± SD 39.90 ± 13.39 years; 2 females and 9 males). Patients were treated with fluvoxamine (FVX) 100-300 mg daily. Clinical assessment was performed using the Hamilton Rating Scales for Anxiety and Depression (HRS-A; HRS-D) and the Clinical Global Impression Scale (CGI) at basal time (T0), after 4 weeks and after 8 weeks (T8). Plasma and platelet amino acid levels were determined at T0 in all the subjects and also at T8 in depressed patients. A significant clinical improvement was observed in depressed patients according to the HRS-A (p = 0.004), HRS-D (p = 0.008) and CGI (p = 0.002). A negative correlation (r = -0.53, p = 0.049) was found between platelet levels of valine and HRS-D improvement rate. Patients showed significantly higher tyrosine/large neutral amino acids (LNAAs) and lower tryptophan/LNAAs, ratios which could represent an index of good response to a serotonergic drug like FVX.
KW - Amino acids
KW - Fluvoxamine
KW - Major depression
UR - http://www.scopus.com/inward/record.url?scp=0035741997&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035741997&partnerID=8YFLogxK
U2 - 10.1159/000054933
DO - 10.1159/000054933
M3 - Article
VL - 44
SP - 134
EP - 138
JO - Neuropsychobiology
JF - Neuropsychobiology
SN - 0302-282X
IS - 3
ER -