Predictive Value of Biological Markers for Hepatocellular Carcinoma Patients Treated with Orthotopic Liver Transplantation

Michelangelo Fiorentino, Annalisa Altimari, Matteo Ravaioli, Elisa Gruppioni, Elena Gabusi, Barbara Corti, Marco Vivarelli, Pierre Paul Bringuier, Jean Yves Scoazec, Walter Franco Grigioni, Antonia D'Errico-Grigioni

Research output: Contribution to journalArticlepeer-review


Purpose: To help stratify candidates with hepatocellular carcinoma (HCC) for orthotopic liver transplantation (OLT), biomarkers are needed that are capable of predicting recurrence of disease (ROD). We investigated the prognostic role in this setting of immunohistochemical markers reported previously to predict poor prognosis in HCC patients treated with resection. Experimental Design: Eighty-three patients with HCC who underwent OLT between 1987 and 2001 with a minimum clinical follow up of 12 months were included in this retrospective study. We analyzed immunohistochemical expression of the adhesion molecules E-cadherin and β-catenin (membrane/nuclear localization), MIB-1 proliferative index and the cyclin-dependent kinase inhibitor p27, along-side the main clinical-pathological variables. Results: At univariate analysis, vascular thrombosis, high MIB-1 index, lower membrane expression of E-cadherin and β-catenin, and nuclear β-catenin localization were associated with ROD. At multivariate analysis, only MIB-1 index, low equal E-cadherin (with respect to non-neoplastic surrounding tissue), and nuclear β-catenin appeared as independent predictors of ROD. The logistic regression analysis model indicated that detection of any one parameter was associated with at least 88% estimated risk of ROD (up to 99% for all three). Conclusions: We propose these three molecular parameters as an additional tool for rational selection of OLT candidates among HCC patients (stratification according to the risk of ROD might help provide a similar life expectancy for cirrhotic candidates with and without HCC).

Original languageEnglish
Pages (from-to)1789-1795
Number of pages7
JournalClinical Cancer Research
Issue number5
Publication statusPublished - Mar 1 2004

ASJC Scopus subject areas

  • Cancer Research
  • Oncology


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