Predictive value of brain perfusion single-photon emission computed tomography in acute ischemic stroke

Franco Giubilei, Gian Luigi Lenzi, Vittorio Di Piero, Carlo Pozzilli, Patrizia Pantano, Stefano Bastianello, Corrado Argentino, Cesare Fieschi

Research output: Contribution to journalArticle

Abstract

We investigated 32 patients with completed ischemic stroke =6 hours after the onset of symptoms by means of computed tomography, cerebral angiography, and technetium-99m-labeled hexamethylpropyleneamtne oxime single-photon emission computed tomography to study cerebral blood flow. Follow-up computed tomography and cerebral blood flow studies were performed 1 week and 1 month after admission. Poor outcome at 1 month was evident in 18 (78%) of the 23 patients with severe neurologic deficit on admission and in 11 (92%) of the 12 patients with severe hypoperfusion in the affected hemisphere on admission. All 10 patients with severe impairment of both neurologic status and cerebral blood flow had a poor outcome at 1 month. We detected severe hypoperfusion in patients with large lesions on computed tomograms or cerebral artery occlusions on angiograms. Cerebral blood flow had increased at the 1-week follow-up despite different clinical outcomes. Our data provide evidence that early evaluation of cerebral blood flow with single-photon emission computed tomography is useful to detect subgroups of patients with different clinical outcomes during the acute phase of ischemic stroke.

Original languageEnglish
Pages (from-to)895-900
Number of pages6
JournalStroke
Volume21
Issue number6
Publication statusPublished - 1990

Fingerprint

Cerebrovascular Circulation
Single-Photon Emission-Computed Tomography
Perfusion
Stroke
Brain
Cerebral Angiography
Cerebral Arteries
Oximes
Technetium
Neurologic Manifestations
Nervous System
Angiography
Tomography

Keywords

  • Cerebral blood flow
  • Cerebral infarction
  • Tomography, emission computed

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Clinical Neurology
  • Advanced and Specialised Nursing
  • Neuroscience(all)

Cite this

Giubilei, F., Lenzi, G. L., Di Piero, V., Pozzilli, C., Pantano, P., Bastianello, S., ... Fieschi, C. (1990). Predictive value of brain perfusion single-photon emission computed tomography in acute ischemic stroke. Stroke, 21(6), 895-900.

Predictive value of brain perfusion single-photon emission computed tomography in acute ischemic stroke. / Giubilei, Franco; Lenzi, Gian Luigi; Di Piero, Vittorio; Pozzilli, Carlo; Pantano, Patrizia; Bastianello, Stefano; Argentino, Corrado; Fieschi, Cesare.

In: Stroke, Vol. 21, No. 6, 1990, p. 895-900.

Research output: Contribution to journalArticle

Giubilei, F, Lenzi, GL, Di Piero, V, Pozzilli, C, Pantano, P, Bastianello, S, Argentino, C & Fieschi, C 1990, 'Predictive value of brain perfusion single-photon emission computed tomography in acute ischemic stroke', Stroke, vol. 21, no. 6, pp. 895-900.
Giubilei, Franco ; Lenzi, Gian Luigi ; Di Piero, Vittorio ; Pozzilli, Carlo ; Pantano, Patrizia ; Bastianello, Stefano ; Argentino, Corrado ; Fieschi, Cesare. / Predictive value of brain perfusion single-photon emission computed tomography in acute ischemic stroke. In: Stroke. 1990 ; Vol. 21, No. 6. pp. 895-900.
@article{ed72b687922e4c24a7c60acb1aa4d533,
title = "Predictive value of brain perfusion single-photon emission computed tomography in acute ischemic stroke",
abstract = "We investigated 32 patients with completed ischemic stroke =6 hours after the onset of symptoms by means of computed tomography, cerebral angiography, and technetium-99m-labeled hexamethylpropyleneamtne oxime single-photon emission computed tomography to study cerebral blood flow. Follow-up computed tomography and cerebral blood flow studies were performed 1 week and 1 month after admission. Poor outcome at 1 month was evident in 18 (78{\%}) of the 23 patients with severe neurologic deficit on admission and in 11 (92{\%}) of the 12 patients with severe hypoperfusion in the affected hemisphere on admission. All 10 patients with severe impairment of both neurologic status and cerebral blood flow had a poor outcome at 1 month. We detected severe hypoperfusion in patients with large lesions on computed tomograms or cerebral artery occlusions on angiograms. Cerebral blood flow had increased at the 1-week follow-up despite different clinical outcomes. Our data provide evidence that early evaluation of cerebral blood flow with single-photon emission computed tomography is useful to detect subgroups of patients with different clinical outcomes during the acute phase of ischemic stroke.",
keywords = "Cerebral blood flow, Cerebral infarction, Tomography, emission computed",
author = "Franco Giubilei and Lenzi, {Gian Luigi} and {Di Piero}, Vittorio and Carlo Pozzilli and Patrizia Pantano and Stefano Bastianello and Corrado Argentino and Cesare Fieschi",
year = "1990",
language = "English",
volume = "21",
pages = "895--900",
journal = "Stroke",
issn = "0039-2499",
publisher = "Lippincott Williams and Wilkins",
number = "6",

}

TY - JOUR

T1 - Predictive value of brain perfusion single-photon emission computed tomography in acute ischemic stroke

AU - Giubilei, Franco

AU - Lenzi, Gian Luigi

AU - Di Piero, Vittorio

AU - Pozzilli, Carlo

AU - Pantano, Patrizia

AU - Bastianello, Stefano

AU - Argentino, Corrado

AU - Fieschi, Cesare

PY - 1990

Y1 - 1990

N2 - We investigated 32 patients with completed ischemic stroke =6 hours after the onset of symptoms by means of computed tomography, cerebral angiography, and technetium-99m-labeled hexamethylpropyleneamtne oxime single-photon emission computed tomography to study cerebral blood flow. Follow-up computed tomography and cerebral blood flow studies were performed 1 week and 1 month after admission. Poor outcome at 1 month was evident in 18 (78%) of the 23 patients with severe neurologic deficit on admission and in 11 (92%) of the 12 patients with severe hypoperfusion in the affected hemisphere on admission. All 10 patients with severe impairment of both neurologic status and cerebral blood flow had a poor outcome at 1 month. We detected severe hypoperfusion in patients with large lesions on computed tomograms or cerebral artery occlusions on angiograms. Cerebral blood flow had increased at the 1-week follow-up despite different clinical outcomes. Our data provide evidence that early evaluation of cerebral blood flow with single-photon emission computed tomography is useful to detect subgroups of patients with different clinical outcomes during the acute phase of ischemic stroke.

AB - We investigated 32 patients with completed ischemic stroke =6 hours after the onset of symptoms by means of computed tomography, cerebral angiography, and technetium-99m-labeled hexamethylpropyleneamtne oxime single-photon emission computed tomography to study cerebral blood flow. Follow-up computed tomography and cerebral blood flow studies were performed 1 week and 1 month after admission. Poor outcome at 1 month was evident in 18 (78%) of the 23 patients with severe neurologic deficit on admission and in 11 (92%) of the 12 patients with severe hypoperfusion in the affected hemisphere on admission. All 10 patients with severe impairment of both neurologic status and cerebral blood flow had a poor outcome at 1 month. We detected severe hypoperfusion in patients with large lesions on computed tomograms or cerebral artery occlusions on angiograms. Cerebral blood flow had increased at the 1-week follow-up despite different clinical outcomes. Our data provide evidence that early evaluation of cerebral blood flow with single-photon emission computed tomography is useful to detect subgroups of patients with different clinical outcomes during the acute phase of ischemic stroke.

KW - Cerebral blood flow

KW - Cerebral infarction

KW - Tomography, emission computed

UR - http://www.scopus.com/inward/record.url?scp=0025277802&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025277802&partnerID=8YFLogxK

M3 - Article

C2 - 2349593

AN - SCOPUS:0025277802

VL - 21

SP - 895

EP - 900

JO - Stroke

JF - Stroke

SN - 0039-2499

IS - 6

ER -