Predictive value of brain perfusion single-photon emission computed tomography in acute ischemic stroke

Franco Giubilei, Gian Luigi Lenzi, Vittorio Di Piero, Carlo Pozzilli, Patrizia Pantano, Stefano Bastianello, Corrado Argentino, Cesare Fieschi

Research output: Contribution to journalArticlepeer-review


We investigated 32 patients with completed ischemic stroke =6 hours after the onset of symptoms by means of computed tomography, cerebral angiography, and technetium-99m-labeled hexamethylpropyleneamtne oxime single-photon emission computed tomography to study cerebral blood flow. Follow-up computed tomography and cerebral blood flow studies were performed 1 week and 1 month after admission. Poor outcome at 1 month was evident in 18 (78%) of the 23 patients with severe neurologic deficit on admission and in 11 (92%) of the 12 patients with severe hypoperfusion in the affected hemisphere on admission. All 10 patients with severe impairment of both neurologic status and cerebral blood flow had a poor outcome at 1 month. We detected severe hypoperfusion in patients with large lesions on computed tomograms or cerebral artery occlusions on angiograms. Cerebral blood flow had increased at the 1-week follow-up despite different clinical outcomes. Our data provide evidence that early evaluation of cerebral blood flow with single-photon emission computed tomography is useful to detect subgroups of patients with different clinical outcomes during the acute phase of ischemic stroke.

Original languageEnglish
Pages (from-to)895-900
Number of pages6
Issue number6
Publication statusPublished - 1990


  • Cerebral blood flow
  • Cerebral infarction
  • Tomography, emission computed

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Clinical Neurology
  • Advanced and Specialised Nursing
  • Neuroscience(all)


Dive into the research topics of 'Predictive value of brain perfusion single-photon emission computed tomography in acute ischemic stroke'. Together they form a unique fingerprint.

Cite this