Predictive value of clinic and ambulatory heart rate for mortality in elderly subjects with systolic hypertension

Paolo Palatini; Lutgarde Thijs; Jan A. Staessen; Robert H. Fagard; Christopher J. Bulpitt; Denis L. Clement; Peter W. De Leeuw; Matti Jaaskivi; Gastone Leonetti; Choudomir Nachev; Eoin T. O'Brien; Gianfranco Parati; José L. Rodicio; Elisabetta Roman; Cinzia Sarti; Jaakko Tuomilehto

doi:10.1001/archinte.162.20.2313

Predictive value of clinic and ambulatory heart rate for mortality in elderly subjects with systolic hypertension

Paolo Palatini, Lutgarde Thijs, Jan A. Staessen, Robert H. Fagard, Christopher J. Bulpitt, Denis L. Clement, Peter W. De Leeuw, Matti Jaaskivi, Gastone Leonetti, Choudomir Nachev, Eoin T. O'Brien, Gianfranco Parati, José L. Rodicio, Elisabetta Roman, Cinzia Sarti, Jaakko Tuomilehto

Fondazione Istituto Auxologico Italiano

Research output: Contribution to journal › Article

Abstract

Objective: To examine the association of clinic and ambulatory heart rate with total, cardiovascular, and noncardiovascular death in a cohort of elderly subjects with isolated systolic hypertension from the Systolic Hypertension in Europe Trial. Methods: A total of 4682 patients participated, whose untreated blood pressure on conventional measurement at baseline was 160 to 219 mm Hg systolic and lower than 95 mm Hg diastolic. Clinic heart rate was the mean of 6 readings during 3 visits. Ambulatory heart rate was recorded with a portable intermittent technique in 807 subjects. Results: Raised baseline clinic heart rate was positively associated with a worse prognosis for total, cardiovascular, and noncardiovascular mortality among the 2293 men and women taking placebo. Subjects with heart rates higher than 79 beats/min (bpm) (top quintile) had a 1.89 times greater risk of mortality than subjects with heart rate lower than or equal to 79 bpm (95% confidence interval, 1.33-2.68 bpm). In a Cox regression analysis, predictors of time to death were heart rate (P

Original language	English
Pages (from-to)	2313-2321
Number of pages	9
Journal	Archives of Internal Medicine
Volume	162
Issue number	20
DOIs	https://doi.org/10.1001/archinte.162.20.2313
Publication status	Published - Nov 15 2002

ASJC Scopus subject areas

Internal Medicine

Access to Document

10.1001/archinte.162.20.2313

Fingerprint Dive into the research topics of 'Predictive value of clinic and ambulatory heart rate for mortality in elderly subjects with systolic hypertension'. Together they form a unique fingerprint.

Cite this

Palatini, P., Thijs, L., Staessen, J. A., Fagard, R. H., Bulpitt, C. J., Clement, D. L., De Leeuw, P. W., Jaaskivi, M., Leonetti, G., Nachev, C., O'Brien, E. T., Parati, G., Rodicio, J. L., Roman, E., Sarti, C., & Tuomilehto, J. (2002). Predictive value of clinic and ambulatory heart rate for mortality in elderly subjects with systolic hypertension. Archives of Internal Medicine, 162(20), 2313-2321. https://doi.org/10.1001/archinte.162.20.2313

Predictive value of clinic and ambulatory heart rate for mortality in elderly subjects with systolic hypertension. / Palatini, Paolo; Thijs, Lutgarde; Staessen, Jan A.; Fagard, Robert H.; Bulpitt, Christopher J.; Clement, Denis L.; De Leeuw, Peter W.; Jaaskivi, Matti; Leonetti, Gastone; Nachev, Choudomir; O'Brien, Eoin T.; Parati, Gianfranco; Rodicio, José L.; Roman, Elisabetta; Sarti, Cinzia; Tuomilehto, Jaakko.

In: Archives of Internal Medicine, Vol. 162, No. 20, 15.11.2002, p. 2313-2321.

Research output: Contribution to journal › Article

Palatini, P, Thijs, L, Staessen, JA, Fagard, RH, Bulpitt, CJ, Clement, DL, De Leeuw, PW, Jaaskivi, M, Leonetti, G, Nachev, C, O'Brien, ET, Parati, G, Rodicio, JL, Roman, E, Sarti, C & Tuomilehto, J 2002, 'Predictive value of clinic and ambulatory heart rate for mortality in elderly subjects with systolic hypertension', Archives of Internal Medicine, vol. 162, no. 20, pp. 2313-2321. https://doi.org/10.1001/archinte.162.20.2313

Palatini, Paolo ; Thijs, Lutgarde ; Staessen, Jan A. ; Fagard, Robert H. ; Bulpitt, Christopher J. ; Clement, Denis L. ; De Leeuw, Peter W. ; Jaaskivi, Matti ; Leonetti, Gastone ; Nachev, Choudomir ; O'Brien, Eoin T. ; Parati, Gianfranco ; Rodicio, José L. ; Roman, Elisabetta ; Sarti, Cinzia ; Tuomilehto, Jaakko. / Predictive value of clinic and ambulatory heart rate for mortality in elderly subjects with systolic hypertension. In: Archives of Internal Medicine. 2002 ; Vol. 162, No. 20. pp. 2313-2321.

@article{8045851f44f0400da6e7bbc7251a8180,

title = "Predictive value of clinic and ambulatory heart rate for mortality in elderly subjects with systolic hypertension",

abstract = "Objective: To examine the association of clinic and ambulatory heart rate with total, cardiovascular, and noncardiovascular death in a cohort of elderly subjects with isolated systolic hypertension from the Systolic Hypertension in Europe Trial. Methods: A total of 4682 patients participated, whose untreated blood pressure on conventional measurement at baseline was 160 to 219 mm Hg systolic and lower than 95 mm Hg diastolic. Clinic heart rate was the mean of 6 readings during 3 visits. Ambulatory heart rate was recorded with a portable intermittent technique in 807 subjects. Results: Raised baseline clinic heart rate was positively associated with a worse prognosis for total, cardiovascular, and noncardiovascular mortality among the 2293 men and women taking placebo. Subjects with heart rates higher than 79 beats/min (bpm) (top quintile) had a 1.89 times greater risk of mortality than subjects with heart rate lower than or equal to 79 bpm (95% confidence interval, 1.33-2.68 bpm). In a Cox regression analysis, predictors of time to death were heart rate (P",

author = "Paolo Palatini and Lutgarde Thijs and Staessen, {Jan A.} and Fagard, {Robert H.} and Bulpitt, {Christopher J.} and Clement, {Denis L.} and {De Leeuw}, {Peter W.} and Matti Jaaskivi and Gastone Leonetti and Choudomir Nachev and O'Brien, {Eoin T.} and Gianfranco Parati and Rodicio, {Jos{\'e} L.} and Elisabetta Roman and Cinzia Sarti and Jaakko Tuomilehto",

year = "2002",

month = nov,

day = "15",

doi = "10.1001/archinte.162.20.2313",

language = "English",

volume = "162",

pages = "2313--2321",

journal = "Archives of Internal Medicine",

issn = "0003-9926",

publisher = "American Medical Association",

number = "20",

}

TY - JOUR

T1 - Predictive value of clinic and ambulatory heart rate for mortality in elderly subjects with systolic hypertension

AU - Palatini, Paolo

AU - Thijs, Lutgarde

AU - Staessen, Jan A.

AU - Fagard, Robert H.

AU - Bulpitt, Christopher J.

AU - Clement, Denis L.

AU - De Leeuw, Peter W.

AU - Jaaskivi, Matti

AU - Leonetti, Gastone

AU - Nachev, Choudomir

AU - O'Brien, Eoin T.

AU - Parati, Gianfranco

AU - Rodicio, José L.

AU - Roman, Elisabetta

AU - Sarti, Cinzia

AU - Tuomilehto, Jaakko

PY - 2002/11/15

Y1 - 2002/11/15

N2 - Objective: To examine the association of clinic and ambulatory heart rate with total, cardiovascular, and noncardiovascular death in a cohort of elderly subjects with isolated systolic hypertension from the Systolic Hypertension in Europe Trial. Methods: A total of 4682 patients participated, whose untreated blood pressure on conventional measurement at baseline was 160 to 219 mm Hg systolic and lower than 95 mm Hg diastolic. Clinic heart rate was the mean of 6 readings during 3 visits. Ambulatory heart rate was recorded with a portable intermittent technique in 807 subjects. Results: Raised baseline clinic heart rate was positively associated with a worse prognosis for total, cardiovascular, and noncardiovascular mortality among the 2293 men and women taking placebo. Subjects with heart rates higher than 79 beats/min (bpm) (top quintile) had a 1.89 times greater risk of mortality than subjects with heart rate lower than or equal to 79 bpm (95% confidence interval, 1.33-2.68 bpm). In a Cox regression analysis, predictors of time to death were heart rate (P

AB - Objective: To examine the association of clinic and ambulatory heart rate with total, cardiovascular, and noncardiovascular death in a cohort of elderly subjects with isolated systolic hypertension from the Systolic Hypertension in Europe Trial. Methods: A total of 4682 patients participated, whose untreated blood pressure on conventional measurement at baseline was 160 to 219 mm Hg systolic and lower than 95 mm Hg diastolic. Clinic heart rate was the mean of 6 readings during 3 visits. Ambulatory heart rate was recorded with a portable intermittent technique in 807 subjects. Results: Raised baseline clinic heart rate was positively associated with a worse prognosis for total, cardiovascular, and noncardiovascular mortality among the 2293 men and women taking placebo. Subjects with heart rates higher than 79 beats/min (bpm) (top quintile) had a 1.89 times greater risk of mortality than subjects with heart rate lower than or equal to 79 bpm (95% confidence interval, 1.33-2.68 bpm). In a Cox regression analysis, predictors of time to death were heart rate (P

UR - http://www.scopus.com/inward/record.url?scp=0037111814&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037111814&partnerID=8YFLogxK

U2 - 10.1001/archinte.162.20.2313

DO - 10.1001/archinte.162.20.2313

M3 - Article

C2 - 12418945

AN - SCOPUS:0037111814

VL - 162

SP - 2313

EP - 2321

JO - Archives of Internal Medicine

JF - Archives of Internal Medicine

SN - 0003-9926

IS - 20

ER -