TY - JOUR
T1 - Predictive value of clinic and ambulatory heart rate for mortality in elderly subjects with systolic hypertension
AU - Palatini, Paolo
AU - Thijs, Lutgarde
AU - Staessen, Jan A.
AU - Fagard, Robert H.
AU - Bulpitt, Christopher J.
AU - Clement, Denis L.
AU - De Leeuw, Peter W.
AU - Jaaskivi, Matti
AU - Leonetti, Gastone
AU - Nachev, Choudomir
AU - O'Brien, Eoin T.
AU - Parati, Gianfranco
AU - Rodicio, José L.
AU - Roman, Elisabetta
AU - Sarti, Cinzia
AU - Tuomilehto, Jaakko
PY - 2002/11/15
Y1 - 2002/11/15
N2 - Objective: To examine the association of clinic and ambulatory heart rate with total, cardiovascular, and noncardiovascular death in a cohort of elderly subjects with isolated systolic hypertension from the Systolic Hypertension in Europe Trial. Methods: A total of 4682 patients participated, whose untreated blood pressure on conventional measurement at baseline was 160 to 219 mm Hg systolic and lower than 95 mm Hg diastolic. Clinic heart rate was the mean of 6 readings during 3 visits. Ambulatory heart rate was recorded with a portable intermittent technique in 807 subjects. Results: Raised baseline clinic heart rate was positively associated with a worse prognosis for total, cardiovascular, and noncardiovascular mortality among the 2293 men and women taking placebo. Subjects with heart rates higher than 79 beats/min (bpm) (top quintile) had a 1.89 times greater risk of mortality than subjects with heart rate lower than or equal to 79 bpm (95% confidence interval, 1.33-2.68 bpm). In a Cox regression analysis, predictors of time to death were heart rate (P
AB - Objective: To examine the association of clinic and ambulatory heart rate with total, cardiovascular, and noncardiovascular death in a cohort of elderly subjects with isolated systolic hypertension from the Systolic Hypertension in Europe Trial. Methods: A total of 4682 patients participated, whose untreated blood pressure on conventional measurement at baseline was 160 to 219 mm Hg systolic and lower than 95 mm Hg diastolic. Clinic heart rate was the mean of 6 readings during 3 visits. Ambulatory heart rate was recorded with a portable intermittent technique in 807 subjects. Results: Raised baseline clinic heart rate was positively associated with a worse prognosis for total, cardiovascular, and noncardiovascular mortality among the 2293 men and women taking placebo. Subjects with heart rates higher than 79 beats/min (bpm) (top quintile) had a 1.89 times greater risk of mortality than subjects with heart rate lower than or equal to 79 bpm (95% confidence interval, 1.33-2.68 bpm). In a Cox regression analysis, predictors of time to death were heart rate (P
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U2 - 10.1001/archinte.162.20.2313
DO - 10.1001/archinte.162.20.2313
M3 - Article
C2 - 12418945
AN - SCOPUS:0037111814
VL - 162
SP - 2313
EP - 2321
JO - Archives of Internal Medicine
JF - Archives of Internal Medicine
SN - 0003-9926
IS - 20
ER -