Predictive value of coagulation tests in arterial thrombosis

Marco Cattaneo, Pier Mannuccio Mannucci

Research output: Contribution to journalArticlepeer-review


In five large-scale prospective studies the predictive value of hemostatic parameters indicating the occurrence of arterial thrombotic diseases has been estimated in healthy individuals. All the studies have consistently found a statistically significant association between hyperfibrinogenemia and arterial thrombotic diseases. In two studies, increased levels of factor VII were associated with an increased incidence of ischemic heart disease. The relationship between arterial occlusive diseases and plasma levels of fibrinogen or factor VII was closer than that for other well established risk factors such as plasma cholesterol. These data indicate the important pathogenetic role carried out by alterations of the clotting system in occlusive arterial diseases.

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalLa Ricerca in Clinica e in Laboratorio
Issue number1
Publication statusPublished - Jan 1988


  • Factor VII
  • Fibrinogen
  • Myocardial infarction
  • Predictive tests
  • Stroke

ASJC Scopus subject areas

  • Clinical Biochemistry


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