Predictive value of dobutamine echocardiography and positron emission tomography in identifying hibernating myocardium in patients with postischaemic heart failure

D. Pagano, R. S. Bonser, J. N. Townend, F. Ordoubadi, R. Lorenzoni, P. G. Camici

Research output: Contribution to journalArticle

115 Citations (Scopus)

Abstract

Objective - To compare the predictive value of dobutamine echocardiography (DE) and positron emission tomography (PET) in identifying reversible chronic left ventricular (LV) dysfunction (hibernating myocardium) in patients with coronary artery disease (CAD) and over heart failure. Patients - 30 patients (four women) with CAD and heart failure undergoing coronary artery bypass grafting (CABG). Methods - Myocardial viability was assessed with DE (5 and 10 μg/kg/min) and PET with [ 18F] 2-fluoro-2- deoxy-D-glucose (FDG) under hyperinsulinaemic euglycaemic clamp. Regional (echo) and global LV function (MUGA) were assessed at baseline and six months after CABG. Results - 192 of the 336 (57%) dysfunctional LV segments improved function following CABG (hibernating) and the LV ejection fraction (EF) increased from 23(7) to 32(9)% (p <0.0001) (in 27 patients > 5%). DE and PET had similar positive predictive values (68% and 66%) in the identification of hibernating myocardium, but DE had a significantly lower negative predictive value than PET (54% υ 96%; p <0.0001). A significant linear correlation was found between the number of PEt viable segments and the changes in EF following CABG (r = 0.65; p = 0.0001). Stepwise logistic regression identified the number of PET viable segments as an independent predictor of improvements in EF > 5%, whereas the number of DE viable segments, the baseline LVEF, and wall motion were not. Conclusions - DE has a higher false negative rate than PET in identifying recoverable LV dysfunction in patients with severe postischaemic heart failure. The amount of PEt viable myocardium correlates with the functional outcome following CABG.

Original languageEnglish
Pages (from-to)281-288
Number of pages8
JournalHeart
Volume79
Issue number3
Publication statusPublished - 1998

Fingerprint

Dobutamine
Positron-Emission Tomography
Echocardiography
Myocardium
Heart Failure
Coronary Artery Bypass
Left Ventricular Dysfunction
Coronary Artery Disease
Glucose Clamp Technique
Fluorodeoxyglucose F18
Left Ventricular Function
Stroke Volume

Keywords

  • Coronary artery disease
  • Dobutamine echocardiography
  • Heart failure
  • Hibernating myocardium
  • Positron emission tomography

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Predictive value of dobutamine echocardiography and positron emission tomography in identifying hibernating myocardium in patients with postischaemic heart failure. / Pagano, D.; Bonser, R. S.; Townend, J. N.; Ordoubadi, F.; Lorenzoni, R.; Camici, P. G.

In: Heart, Vol. 79, No. 3, 1998, p. 281-288.

Research output: Contribution to journalArticle

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title = "Predictive value of dobutamine echocardiography and positron emission tomography in identifying hibernating myocardium in patients with postischaemic heart failure",
abstract = "Objective - To compare the predictive value of dobutamine echocardiography (DE) and positron emission tomography (PET) in identifying reversible chronic left ventricular (LV) dysfunction (hibernating myocardium) in patients with coronary artery disease (CAD) and over heart failure. Patients - 30 patients (four women) with CAD and heart failure undergoing coronary artery bypass grafting (CABG). Methods - Myocardial viability was assessed with DE (5 and 10 μg/kg/min) and PET with [ 18F] 2-fluoro-2- deoxy-D-glucose (FDG) under hyperinsulinaemic euglycaemic clamp. Regional (echo) and global LV function (MUGA) were assessed at baseline and six months after CABG. Results - 192 of the 336 (57{\%}) dysfunctional LV segments improved function following CABG (hibernating) and the LV ejection fraction (EF) increased from 23(7) to 32(9){\%} (p <0.0001) (in 27 patients > 5{\%}). DE and PET had similar positive predictive values (68{\%} and 66{\%}) in the identification of hibernating myocardium, but DE had a significantly lower negative predictive value than PET (54{\%} υ 96{\%}; p <0.0001). A significant linear correlation was found between the number of PEt viable segments and the changes in EF following CABG (r = 0.65; p = 0.0001). Stepwise logistic regression identified the number of PET viable segments as an independent predictor of improvements in EF > 5{\%}, whereas the number of DE viable segments, the baseline LVEF, and wall motion were not. Conclusions - DE has a higher false negative rate than PET in identifying recoverable LV dysfunction in patients with severe postischaemic heart failure. The amount of PEt viable myocardium correlates with the functional outcome following CABG.",
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T1 - Predictive value of dobutamine echocardiography and positron emission tomography in identifying hibernating myocardium in patients with postischaemic heart failure

AU - Pagano, D.

AU - Bonser, R. S.

AU - Townend, J. N.

AU - Ordoubadi, F.

AU - Lorenzoni, R.

AU - Camici, P. G.

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N2 - Objective - To compare the predictive value of dobutamine echocardiography (DE) and positron emission tomography (PET) in identifying reversible chronic left ventricular (LV) dysfunction (hibernating myocardium) in patients with coronary artery disease (CAD) and over heart failure. Patients - 30 patients (four women) with CAD and heart failure undergoing coronary artery bypass grafting (CABG). Methods - Myocardial viability was assessed with DE (5 and 10 μg/kg/min) and PET with [ 18F] 2-fluoro-2- deoxy-D-glucose (FDG) under hyperinsulinaemic euglycaemic clamp. Regional (echo) and global LV function (MUGA) were assessed at baseline and six months after CABG. Results - 192 of the 336 (57%) dysfunctional LV segments improved function following CABG (hibernating) and the LV ejection fraction (EF) increased from 23(7) to 32(9)% (p <0.0001) (in 27 patients > 5%). DE and PET had similar positive predictive values (68% and 66%) in the identification of hibernating myocardium, but DE had a significantly lower negative predictive value than PET (54% υ 96%; p <0.0001). A significant linear correlation was found between the number of PEt viable segments and the changes in EF following CABG (r = 0.65; p = 0.0001). Stepwise logistic regression identified the number of PET viable segments as an independent predictor of improvements in EF > 5%, whereas the number of DE viable segments, the baseline LVEF, and wall motion were not. Conclusions - DE has a higher false negative rate than PET in identifying recoverable LV dysfunction in patients with severe postischaemic heart failure. The amount of PEt viable myocardium correlates with the functional outcome following CABG.

AB - Objective - To compare the predictive value of dobutamine echocardiography (DE) and positron emission tomography (PET) in identifying reversible chronic left ventricular (LV) dysfunction (hibernating myocardium) in patients with coronary artery disease (CAD) and over heart failure. Patients - 30 patients (four women) with CAD and heart failure undergoing coronary artery bypass grafting (CABG). Methods - Myocardial viability was assessed with DE (5 and 10 μg/kg/min) and PET with [ 18F] 2-fluoro-2- deoxy-D-glucose (FDG) under hyperinsulinaemic euglycaemic clamp. Regional (echo) and global LV function (MUGA) were assessed at baseline and six months after CABG. Results - 192 of the 336 (57%) dysfunctional LV segments improved function following CABG (hibernating) and the LV ejection fraction (EF) increased from 23(7) to 32(9)% (p <0.0001) (in 27 patients > 5%). DE and PET had similar positive predictive values (68% and 66%) in the identification of hibernating myocardium, but DE had a significantly lower negative predictive value than PET (54% υ 96%; p <0.0001). A significant linear correlation was found between the number of PEt viable segments and the changes in EF following CABG (r = 0.65; p = 0.0001). Stepwise logistic regression identified the number of PET viable segments as an independent predictor of improvements in EF > 5%, whereas the number of DE viable segments, the baseline LVEF, and wall motion were not. Conclusions - DE has a higher false negative rate than PET in identifying recoverable LV dysfunction in patients with severe postischaemic heart failure. The amount of PEt viable myocardium correlates with the functional outcome following CABG.

KW - Coronary artery disease

KW - Dobutamine echocardiography

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KW - Positron emission tomography

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