Predictive value of EEG for febrile seizure recurrence

Alberto M. Cappellari, Carolina Brizio, Marta B. Mazzoni, Giuseppe Bertolozzi, Federica Vianello, Alessia Rocchi, Massimo Belli, Andrea Nossa, Dario Consonni, Gregorio P. Milani, Emilio F. Fossali

Research output: Contribution to journalArticlepeer-review


Objective: To define the role of the EEG in predicting recurrence of febrile seizures (FS) in children after a first FS. Methods: Children with a first simple or complex FS who underwent EEG at our hospital were retrospectively enrolled. EEG recordings were classified in three groups: normal, abnormal (slow activity or epileptiform discharges), and pseudo-petit mal discharge (PPMD) pattern. Children were followed-up for at least three years. Results: A total of 126 patients met the entry criteria, and 113 of them completed the follow-up. Risk of FS recurrence decreased linearly with increasing age (-2% per month). The risk was higher among patients with PPMD pattern (absolute risk 86%, adjusted relative risk 2.00) and abnormal EEG (epileptiform discharges: absolute risk 71%, adjusted relative risk 2.00; slow activity: absolute risk 56%, adjusted relative risk 1.44), compared with those with normal EEG (absolute risk 41%). Conclusions: PPMD and abnormal EEG should be considered as an independent risk factor for FS recurrence.

Original languageEnglish
Pages (from-to)311-315
JournalBrain and Development
Issue number4
Publication statusPublished - 2018


  • EEG
  • Febrile seizures
  • Pseudo-petit mal discharge

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Developmental Neuroscience
  • Clinical Neurology


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