TY - JOUR
T1 - Predictive value of high titer of GAD65 antibodies in a case of limbic encephalitis
AU - Di Giacomo, Roberta
AU - Deleo, Francesco
AU - Pastori, Chiara
AU - Didato, Giuseppe
AU - Andreetta, Francesca
AU - Del Sole, Angelo
AU - de Curtis, Marco
AU - Villani, Flavio
PY - 2019/12/15
Y1 - 2019/12/15
N2 - We report the case of a 42-year-old woman who presented with vertigo and migraine and rapidly developed cognitive decline and seizures. Both serum and cerebro-spinal fluid samples showed high titer of anti-glutamic acid decarboxylase (anti-GAD65) antibodies (998,881 IU/ml and 54,687 IU/ml respectively). Limbic encephalitis was diagnosed and high dose steroids treatment started. During one-year follow-up, without further immunomodulatory therapy, the patient became seizure free, and cognitive functions returned to normal. Serum anti-GAD65 antibodies titer decreased significantly but remained elevated (192,680 IU/ml). We discuss the prognostic and pathogenic value of high titer anti-GAD65 antibodies and its variations in a case of autoimmune limbic encephalitis.
AB - We report the case of a 42-year-old woman who presented with vertigo and migraine and rapidly developed cognitive decline and seizures. Both serum and cerebro-spinal fluid samples showed high titer of anti-glutamic acid decarboxylase (anti-GAD65) antibodies (998,881 IU/ml and 54,687 IU/ml respectively). Limbic encephalitis was diagnosed and high dose steroids treatment started. During one-year follow-up, without further immunomodulatory therapy, the patient became seizure free, and cognitive functions returned to normal. Serum anti-GAD65 antibodies titer decreased significantly but remained elevated (192,680 IU/ml). We discuss the prognostic and pathogenic value of high titer anti-GAD65 antibodies and its variations in a case of autoimmune limbic encephalitis.
KW - Anti-glutamic acid decarboxylase 65 antibody
KW - Autoimmune encephalitis
KW - Immunotherapy
KW - Limbic encephalitis
KW - Neuroimmunology
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U2 - 10.1016/j.jneuroim.2019.577063
DO - 10.1016/j.jneuroim.2019.577063
M3 - Article
AN - SCOPUS:85072053518
VL - 337
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
SN - 0165-5728
M1 - 577063
ER -