Predictive value of high titer of GAD65 antibodies in a case of limbic encephalitis

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We report the case of a 42-year-old woman who presented with vertigo and migraine and rapidly developed cognitive decline and seizures. Both serum and cerebro-spinal fluid samples showed high titer of anti-glutamic acid decarboxylase (anti-GAD65) antibodies (998,881 IU/ml and 54,687 IU/ml respectively). Limbic encephalitis was diagnosed and high dose steroids treatment started. During one-year follow-up, without further immunomodulatory therapy, the patient became seizure free, and cognitive functions returned to normal. Serum anti-GAD65 antibodies titer decreased significantly but remained elevated (192,680 IU/ml). We discuss the prognostic and pathogenic value of high titer anti-GAD65 antibodies and its variations in a case of autoimmune limbic encephalitis.

Original languageEnglish
Article number577063
JournalJournal of Neuroimmunology
Publication statusPublished - Dec 15 2019


  • Anti-glutamic acid decarboxylase 65 antibody
  • Autoimmune encephalitis
  • Immunotherapy
  • Limbic encephalitis
  • Neuroimmunology

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology


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