Predictive value of preintervention C-reactive protein on clinical outcome after directional coronary atherectomy followed by stent implantation

Giampaolo Niccoli, Giuseppe Ferrante, Rocco Mongiardo, Matteo Perfetti, Flavia Belloni, Francesco Burzotta, Italo Porto, Antonio Maria Leone, Antonio G. Rebuzzi, Filippo Crea

Research output: Contribution to journalArticle

Abstract

Background: Preprocedural C-reactive protein (CRP) serum levels have been shown to predict the recurrence of angina or major adverse cardiac events after percutaneous coronary intervention. Directional coronary atherectomy (DCA), by reducing residual plaque burden and restenosis, has been shown to improve clinical outcome after coronary stenting. Thus, we assessed the influence of preprocedural CRP serum levels on the recurrence of cardiac events after DCA followed by bare metal stent implantation. Methods: We enrolled 40 consecutive patients (34 males; 61±10 years old) with single-vessel disease who were undergoing DCA. In all patients, preprocedural CRP serum levels were measured by an ultrasensitive nephelometric method. The endpoint of the study was defined as the composite incidence of death, myocardial infarction, and recurrence of angina requiring repeat revascularization at 6-month follow-up. Results: CRP serum levels were a significant independent predictor of the composite endpoint at multiple regression analysis [odds ratio=1.69; 95% confidence interval (95% CI)=1.04-2.75; P=.033]. Patients with recurrence of cardiac events had CRP serum levels higher than those of patients not having events on follow-up [3.95 (2.2-5.7) vs. 2 (1.3-3.3); P=.05]. Conclusion: In conclusion, our study shows that baseline CRP serum levels predict cardiac events after coronary bare metal stenting despite plaque debulking with directional atherectomy.

Original languageEnglish
Pages (from-to)156-160
Number of pages5
JournalCardiovascular Revascularization Medicine
Volume8
Issue number3
DOIs
Publication statusPublished - Jul 2007

Keywords

  • C-reactive protein
  • Directional coronary atherectomy
  • Prognosis

ASJC Scopus subject areas

  • Molecular Medicine
  • Cardiology and Cardiovascular Medicine
  • Surgery

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