TY - JOUR
T1 - Predictive Value of the Differential Expression of the Urokinase Plasminogen Activation Axis in Radical Prostatectomy Patients
AU - Gupta, Amit
AU - Lotan, Yair
AU - Ashfaq, Raheela
AU - Roehrborn, Claus G.
AU - Raj, Ganesh V.
AU - Aragaki, Corinne C.
AU - Montorsi, Francesco
AU - Shariat, Shahrokh F.
PY - 2009/5
Y1 - 2009/5
N2 - Background: The urokinase plasminogen axis is composed of urokinase plasminogen activator (uPA), its receptor (uPAR), and its inhibitors (PAI-1 and PAI-2). This axis is involved in cell proliferation, angiogenesis, extracellular matrix degradation, invasion, and metastases. Objective: To assess the relationship of the uPA axis with pathologic features and outcomes in prostate cancer. Design, setting, and participants: Retrospective study of 230 consecutive patients treated with radical prostatectomy for clinically localized disease. Interventions: None. Measurements: Immunohistochemical staining for uPA, uPAR, and PAI-1 were carried out on serial archival tissue microarray specimens. These markers were histologically categorized as normal or overexpressed. Disease recurrence was classified as aggressive if metastases were present, if postrecurrence prostate-specific antigen (PSA) doubling time was
AB - Background: The urokinase plasminogen axis is composed of urokinase plasminogen activator (uPA), its receptor (uPAR), and its inhibitors (PAI-1 and PAI-2). This axis is involved in cell proliferation, angiogenesis, extracellular matrix degradation, invasion, and metastases. Objective: To assess the relationship of the uPA axis with pathologic features and outcomes in prostate cancer. Design, setting, and participants: Retrospective study of 230 consecutive patients treated with radical prostatectomy for clinically localized disease. Interventions: None. Measurements: Immunohistochemical staining for uPA, uPAR, and PAI-1 were carried out on serial archival tissue microarray specimens. These markers were histologically categorized as normal or overexpressed. Disease recurrence was classified as aggressive if metastases were present, if postrecurrence prostate-specific antigen (PSA) doubling time was
KW - Biochemical failure
KW - Prostatic neoplasms
KW - Radical Prostatectomy
KW - Recurrence
KW - Urokinase plasminogen activator
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U2 - 10.1016/j.eururo.2008.06.054
DO - 10.1016/j.eururo.2008.06.054
M3 - Article
C2 - 18585843
AN - SCOPUS:62649132399
VL - 55
SP - 1124
EP - 1134
JO - European Urology
JF - European Urology
SN - 0302-2838
IS - 5
ER -