Predictive Value of the Differential Expression of the Urokinase Plasminogen Activation Axis in Radical Prostatectomy Patients

Amit Gupta, Yair Lotan, Raheela Ashfaq, Claus G. Roehrborn, Ganesh V. Raj, Corinne C. Aragaki, Francesco Montorsi, Shahrokh F. Shariat

Research output: Contribution to journal › Article

Abstract

Background: The urokinase plasminogen axis is composed of urokinase plasminogen activator (uPA), its receptor (uPAR), and its inhibitors (PAI-1 and PAI-2). This axis is involved in cell proliferation, angiogenesis, extracellular matrix degradation, invasion, and metastases. Objective: To assess the relationship of the uPA axis with pathologic features and outcomes in prostate cancer. Design, setting, and participants: Retrospective study of 230 consecutive patients treated with radical prostatectomy for clinically localized disease. Interventions: None. Measurements: Immunohistochemical staining for uPA, uPAR, and PAI-1 were carried out on serial archival tissue microarray specimens. These markers were histologically categorized as normal or overexpressed. Disease recurrence was classified as aggressive if metastases were present, if postrecurrence prostate-specific antigen (PSA) doubling time was

Original languageEnglish
Pages (from-to)1124-1134
Number of pages11
JournalEuropean Urology
Volume55
Issue number5
DOIs
Publication statusPublished - May 2009

Fingerprint

Plasminogen
Urokinase-Type Plasminogen Activator
Prostatectomy
Plasminogen Activators
Plasminogen Activator Inhibitor 1
Plasminogen Activator Inhibitor 2
Urokinase Plasminogen Activator Receptors
Neoplasm Metastasis
Prostate-Specific Antigen
Extracellular Matrix
Prostatic Neoplasms
Retrospective Studies
Cell Proliferation
Staining and Labeling
Recurrence

Keywords

  • Biochemical failure
  • Prostatic neoplasms
  • Radical Prostatectomy
  • Recurrence
  • Urokinase plasminogen activator

ASJC Scopus subject areas

  • Urology

Cite this

Gupta, A., Lotan, Y., Ashfaq, R., Roehrborn, C. G., Raj, G. V., Aragaki, C. C., ... Shariat, S. F. (2009). Predictive Value of the Differential Expression of the Urokinase Plasminogen Activation Axis in Radical Prostatectomy Patients. European Urology, 55(5), 1124-1134. https://doi.org/10.1016/j.eururo.2008.06.054

Predictive Value of the Differential Expression of the Urokinase Plasminogen Activation Axis in Radical Prostatectomy Patients. / Gupta, Amit; Lotan, Yair; Ashfaq, Raheela; Roehrborn, Claus G.; Raj, Ganesh V.; Aragaki, Corinne C.; Montorsi, Francesco; Shariat, Shahrokh F.

In: European Urology, Vol. 55, No. 5, 05.2009, p. 1124-1134.

Research output: Contribution to journal › Article

Gupta, A, Lotan, Y, Ashfaq, R, Roehrborn, CG, Raj, GV, Aragaki, CC, Montorsi, F & Shariat, SF 2009, 'Predictive Value of the Differential Expression of the Urokinase Plasminogen Activation Axis in Radical Prostatectomy Patients', European Urology, vol. 55, no. 5, pp. 1124-1134. https://doi.org/10.1016/j.eururo.2008.06.054
Gupta A, Lotan Y, Ashfaq R, Roehrborn CG, Raj GV, Aragaki CC et al. Predictive Value of the Differential Expression of the Urokinase Plasminogen Activation Axis in Radical Prostatectomy Patients. European Urology. 2009 May;55(5):1124-1134. https://doi.org/10.1016/j.eururo.2008.06.054
Gupta, Amit ; Lotan, Yair ; Ashfaq, Raheela ; Roehrborn, Claus G. ; Raj, Ganesh V. ; Aragaki, Corinne C. ; Montorsi, Francesco ; Shariat, Shahrokh F. / Predictive Value of the Differential Expression of the Urokinase Plasminogen Activation Axis in Radical Prostatectomy Patients. In: European Urology. 2009 ; Vol. 55, No. 5. pp. 1124-1134.
@article{103ec558b103446c8666f3222aa1cbe4,
title = "Predictive Value of the Differential Expression of the Urokinase Plasminogen Activation Axis in Radical Prostatectomy Patients",
abstract = "Background: The urokinase plasminogen axis is composed of urokinase plasminogen activator (uPA), its receptor (uPAR), and its inhibitors (PAI-1 and PAI-2). This axis is involved in cell proliferation, angiogenesis, extracellular matrix degradation, invasion, and metastases. Objective: To assess the relationship of the uPA axis with pathologic features and outcomes in prostate cancer. Design, setting, and participants: Retrospective study of 230 consecutive patients treated with radical prostatectomy for clinically localized disease. Interventions: None. Measurements: Immunohistochemical staining for uPA, uPAR, and PAI-1 were carried out on serial archival tissue microarray specimens. These markers were histologically categorized as normal or overexpressed. Disease recurrence was classified as aggressive if metastases were present, if postrecurrence prostate-specific antigen (PSA) doubling time was",
keywords = "Biochemical failure, Prostatic neoplasms, Radical Prostatectomy, Recurrence, Urokinase plasminogen activator",
author = "Amit Gupta and Yair Lotan and Raheela Ashfaq and Roehrborn, {Claus G.} and Raj, {Ganesh V.} and Aragaki, {Corinne C.} and Francesco Montorsi and Shariat, {Shahrokh F.}",
year = "2009",
month = "5",
doi = "10.1016/j.eururo.2008.06.054",
language = "English",
volume = "55",
pages = "1124--1134",
journal = "European Urology",
issn = "0302-2838",
publisher = "Elsevier B.V.",
number = "5",

}

TY - JOUR

T1 - Predictive Value of the Differential Expression of the Urokinase Plasminogen Activation Axis in Radical Prostatectomy Patients

AU - Gupta, Amit

AU - Lotan, Yair

AU - Ashfaq, Raheela

AU - Roehrborn, Claus G.

AU - Raj, Ganesh V.

AU - Aragaki, Corinne C.

AU - Montorsi, Francesco

AU - Shariat, Shahrokh F.

PY - 2009/5

Y1 - 2009/5

N2 - Background: The urokinase plasminogen axis is composed of urokinase plasminogen activator (uPA), its receptor (uPAR), and its inhibitors (PAI-1 and PAI-2). This axis is involved in cell proliferation, angiogenesis, extracellular matrix degradation, invasion, and metastases. Objective: To assess the relationship of the uPA axis with pathologic features and outcomes in prostate cancer. Design, setting, and participants: Retrospective study of 230 consecutive patients treated with radical prostatectomy for clinically localized disease. Interventions: None. Measurements: Immunohistochemical staining for uPA, uPAR, and PAI-1 were carried out on serial archival tissue microarray specimens. These markers were histologically categorized as normal or overexpressed. Disease recurrence was classified as aggressive if metastases were present, if postrecurrence prostate-specific antigen (PSA) doubling time was

AB - Background: The urokinase plasminogen axis is composed of urokinase plasminogen activator (uPA), its receptor (uPAR), and its inhibitors (PAI-1 and PAI-2). This axis is involved in cell proliferation, angiogenesis, extracellular matrix degradation, invasion, and metastases. Objective: To assess the relationship of the uPA axis with pathologic features and outcomes in prostate cancer. Design, setting, and participants: Retrospective study of 230 consecutive patients treated with radical prostatectomy for clinically localized disease. Interventions: None. Measurements: Immunohistochemical staining for uPA, uPAR, and PAI-1 were carried out on serial archival tissue microarray specimens. These markers were histologically categorized as normal or overexpressed. Disease recurrence was classified as aggressive if metastases were present, if postrecurrence prostate-specific antigen (PSA) doubling time was

KW - Biochemical failure

KW - Prostatic neoplasms

KW - Radical Prostatectomy

KW - Recurrence

KW - Urokinase plasminogen activator

UR - http://www.scopus.com/inward/record.url?scp=62649132399&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=62649132399&partnerID=8YFLogxK

U2 - 10.1016/j.eururo.2008.06.054

DO - 10.1016/j.eururo.2008.06.054

M3 - Article

C2 - 18585843

AN - SCOPUS:62649132399

VL - 55

SP - 1124

EP - 1134

JO - European Urology

JF - European Urology

SN - 0302-2838

IS - 5

ER -

Access to Document