Predictive Value of the Differential Expression of the Urokinase Plasminogen Activation Axis in Radical Prostatectomy Patients

Amit Gupta, Yair Lotan, Raheela Ashfaq, Claus G. Roehrborn, Ganesh V. Raj, Corinne C. Aragaki, Francesco Montorsi, Shahrokh F. Shariat

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The urokinase plasminogen axis is composed of urokinase plasminogen activator (uPA), its receptor (uPAR), and its inhibitors (PAI-1 and PAI-2). This axis is involved in cell proliferation, angiogenesis, extracellular matrix degradation, invasion, and metastases. Objective: To assess the relationship of the uPA axis with pathologic features and outcomes in prostate cancer. Design, setting, and participants: Retrospective study of 230 consecutive patients treated with radical prostatectomy for clinically localized disease. Interventions: None. Measurements: Immunohistochemical staining for uPA, uPAR, and PAI-1 were carried out on serial archival tissue microarray specimens. These markers were histologically categorized as normal or overexpressed. Disease recurrence was classified as aggressive if metastases were present, if postrecurrence prostate-specific antigen (PSA) doubling time was

Original languageEnglish
Pages (from-to)1124-1134
Number of pages11
JournalEuropean Urology
Volume55
Issue number5
DOIs
Publication statusPublished - May 2009

Keywords

  • Biochemical failure
  • Prostatic neoplasms
  • Radical Prostatectomy
  • Recurrence
  • Urokinase plasminogen activator

ASJC Scopus subject areas

  • Urology

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