Abstract
Background: A condition of maternal thrombophilia, either inherited or acquired, can compromise the success of implantation and foetal survival. Methods: Malfunctions in protein C pathway were evaluated using a novel assay [HemosIL ThromboPath (ThP)] in a case-control study of 172 women with a history of recurrent miscarriage or infertility and 86 age-matched unrelated fertile women. Results: Thrombophilia was ascertained in 13% of the cases. ThP values were lower in women either with or without thrombophilia compared to controls (both p <0.0001). Abnormal ThP values (below the mean minus 1SD of controls) were found in 62% of cases compared to 12% of controls (p <0.0001). Non-thrombophilic women who achieved spontaneous pregnancy had higher ThP values compared to those who did not (p <0.05). Elevated ThP values were an independent predictor for pregnancy (p <0.01) in women without thrombophilia. A decrease of ThP values was observed during pregnancy progression, which correlated with that of protein S (p <0.05). Miscarriage or major complications occurred in women in whom ThP percent change was approximately 2-fold higher than that observed in women who achieved successful pregnancy (p <0.05). Conclusions: ThP might represent an efficient assay for screening women with pregnancy complications and might provide prognostic information during pregnancy progression.
| Original language | English |
|---|---|
| Pages (from-to) | 37-42 |
| Number of pages | 6 |
| Journal | Clinica Chimica Acta |
| Volume | 411 |
| Issue number | 1-2 |
| DOIs | |
| Publication status | Published - Jan 4 2010 |
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Keywords
- Infertility
- Miscarriage
- Pregnancy
- Thrombophilia
ASJC Scopus subject areas
- Biochemistry
- Clinical Biochemistry
- Biochemistry, medical
Cite this
Predictive value of thrombopath determination in women with infertility and pregnancy complications. / Ferroni, Patrizia; La Farina, Francesca; Palmirotta, Raffaele; Martini, Francesca; Raparelli, Valeria; Nigro, Carmen; Riondino, Silvia; Rampini, Maria Rita; Basili, Stefania; Guadagni, Fiorella.
In: Clinica Chimica Acta, Vol. 411, No. 1-2, 04.01.2010, p. 37-42.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Predictive value of thrombopath determination in women with infertility and pregnancy complications
AU - Ferroni, Patrizia
AU - La Farina, Francesca
AU - Palmirotta, Raffaele
AU - Martini, Francesca
AU - Raparelli, Valeria
AU - Nigro, Carmen
AU - Riondino, Silvia
AU - Rampini, Maria Rita
AU - Basili, Stefania
AU - Guadagni, Fiorella
PY - 2010/1/4
Y1 - 2010/1/4
N2 - Background: A condition of maternal thrombophilia, either inherited or acquired, can compromise the success of implantation and foetal survival. Methods: Malfunctions in protein C pathway were evaluated using a novel assay [HemosIL ThromboPath (ThP)] in a case-control study of 172 women with a history of recurrent miscarriage or infertility and 86 age-matched unrelated fertile women. Results: Thrombophilia was ascertained in 13% of the cases. ThP values were lower in women either with or without thrombophilia compared to controls (both p <0.0001). Abnormal ThP values (below the mean minus 1SD of controls) were found in 62% of cases compared to 12% of controls (p <0.0001). Non-thrombophilic women who achieved spontaneous pregnancy had higher ThP values compared to those who did not (p <0.05). Elevated ThP values were an independent predictor for pregnancy (p <0.01) in women without thrombophilia. A decrease of ThP values was observed during pregnancy progression, which correlated with that of protein S (p <0.05). Miscarriage or major complications occurred in women in whom ThP percent change was approximately 2-fold higher than that observed in women who achieved successful pregnancy (p <0.05). Conclusions: ThP might represent an efficient assay for screening women with pregnancy complications and might provide prognostic information during pregnancy progression.
AB - Background: A condition of maternal thrombophilia, either inherited or acquired, can compromise the success of implantation and foetal survival. Methods: Malfunctions in protein C pathway were evaluated using a novel assay [HemosIL ThromboPath (ThP)] in a case-control study of 172 women with a history of recurrent miscarriage or infertility and 86 age-matched unrelated fertile women. Results: Thrombophilia was ascertained in 13% of the cases. ThP values were lower in women either with or without thrombophilia compared to controls (both p <0.0001). Abnormal ThP values (below the mean minus 1SD of controls) were found in 62% of cases compared to 12% of controls (p <0.0001). Non-thrombophilic women who achieved spontaneous pregnancy had higher ThP values compared to those who did not (p <0.05). Elevated ThP values were an independent predictor for pregnancy (p <0.01) in women without thrombophilia. A decrease of ThP values was observed during pregnancy progression, which correlated with that of protein S (p <0.05). Miscarriage or major complications occurred in women in whom ThP percent change was approximately 2-fold higher than that observed in women who achieved successful pregnancy (p <0.05). Conclusions: ThP might represent an efficient assay for screening women with pregnancy complications and might provide prognostic information during pregnancy progression.
KW - Infertility
KW - Miscarriage
KW - Pregnancy
KW - Thrombophilia
UR - http://www.scopus.com/inward/record.url?scp=70449533734&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=70449533734&partnerID=8YFLogxK
U2 - 10.1016/j.cca.2009.09.035
DO - 10.1016/j.cca.2009.09.035
M3 - Article
VL - 411
SP - 37
EP - 42
JO - Clinica Chimica Acta
JF - Clinica Chimica Acta
SN - 0009-8981
IS - 1-2
ER -