TY - JOUR
T1 - Predictive value of thrombopath determination in women with infertility and pregnancy complications
AU - Ferroni, Patrizia
AU - La Farina, Francesca
AU - Palmirotta, Raffaele
AU - Martini, Francesca
AU - Raparelli, Valeria
AU - Nigro, Carmen
AU - Riondino, Silvia
AU - Rampini, Maria Rita
AU - Basili, Stefania
AU - Guadagni, Fiorella
PY - 2010/1/4
Y1 - 2010/1/4
N2 - Background: A condition of maternal thrombophilia, either inherited or acquired, can compromise the success of implantation and foetal survival. Methods: Malfunctions in protein C pathway were evaluated using a novel assay [HemosIL ThromboPath (ThP)] in a case-control study of 172 women with a history of recurrent miscarriage or infertility and 86 age-matched unrelated fertile women. Results: Thrombophilia was ascertained in 13% of the cases. ThP values were lower in women either with or without thrombophilia compared to controls (both p <0.0001). Abnormal ThP values (below the mean minus 1SD of controls) were found in 62% of cases compared to 12% of controls (p <0.0001). Non-thrombophilic women who achieved spontaneous pregnancy had higher ThP values compared to those who did not (p <0.05). Elevated ThP values were an independent predictor for pregnancy (p <0.01) in women without thrombophilia. A decrease of ThP values was observed during pregnancy progression, which correlated with that of protein S (p <0.05). Miscarriage or major complications occurred in women in whom ThP percent change was approximately 2-fold higher than that observed in women who achieved successful pregnancy (p <0.05). Conclusions: ThP might represent an efficient assay for screening women with pregnancy complications and might provide prognostic information during pregnancy progression.
AB - Background: A condition of maternal thrombophilia, either inherited or acquired, can compromise the success of implantation and foetal survival. Methods: Malfunctions in protein C pathway were evaluated using a novel assay [HemosIL ThromboPath (ThP)] in a case-control study of 172 women with a history of recurrent miscarriage or infertility and 86 age-matched unrelated fertile women. Results: Thrombophilia was ascertained in 13% of the cases. ThP values were lower in women either with or without thrombophilia compared to controls (both p <0.0001). Abnormal ThP values (below the mean minus 1SD of controls) were found in 62% of cases compared to 12% of controls (p <0.0001). Non-thrombophilic women who achieved spontaneous pregnancy had higher ThP values compared to those who did not (p <0.05). Elevated ThP values were an independent predictor for pregnancy (p <0.01) in women without thrombophilia. A decrease of ThP values was observed during pregnancy progression, which correlated with that of protein S (p <0.05). Miscarriage or major complications occurred in women in whom ThP percent change was approximately 2-fold higher than that observed in women who achieved successful pregnancy (p <0.05). Conclusions: ThP might represent an efficient assay for screening women with pregnancy complications and might provide prognostic information during pregnancy progression.
KW - Infertility
KW - Miscarriage
KW - Pregnancy
KW - Thrombophilia
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U2 - 10.1016/j.cca.2009.09.035
DO - 10.1016/j.cca.2009.09.035
M3 - Article
C2 - 19808032
AN - SCOPUS:70449533734
VL - 411
SP - 37
EP - 42
JO - Clinica Chimica Acta
JF - Clinica Chimica Acta
SN - 0009-8981
IS - 1-2
ER -