Predictivity of clinical, laboratory and imaging findings in diagnostic definition of palpable thyroid nodules. A multicenter prospective study

Maria Grazia Chiofalo, Simona Signoriello, Franco Fulciniti, Nicola Avenia, Serenella Ristagno, Celestino Pio Lombardi, Angelo Nicolosi, Maria Rosa Pelizzo, Giuliano Perigli, Andrea Polistena, Vincenzo Panebianco, Rocco Bellantone, Pietro Giorgio Calò, Isabella Merante Boschin, Benedetta Badii, Massimo Di Maio, Ciro Gallo, Francesco Perrone, Luciano Pezzullo

Research output: Contribution to journalArticle

Abstract

Abstract: Purpose: To assess the role of clinical, biochemical, and morphological parameters, as added to cytology, for improving pre-surgical diagnosis of palpable thyroid nodules. Abstract: Methods: Patients with a palpable thyroid nodule were eligible if surgical intervention was indicated after a positive or suspicious for malignancy FNAC (TIR 4–5 according to the 2007 Italian SIAPEC-IAP classification), or two inconclusive FNAC at a ≥3 months interval, or a negative FNAC associated with one or more risk factor. Reference standard was histological malignancy diagnosis. Likelihood ratios of malignancy, sensitivity, specificity, negative (NPV), and positive predictive value (PPV) were described. Multiple correspondence analysis (MCA) and logistic regression were applied. Abstract: Results: Cancer was found in 433/902 (48%) patients. Considering TIR4–5 only as positive cytology, specificity, and PPV were high (94 and 91%) but sensitivity and NPV were low (61 and 72%); conversely, including TIR3 among positive, sensitivity and NPV were higher (88 and 82%) while specificity and PPV decreased (52 and 63%). Ultrasonographic size ≥3 cm was independently associated with benignity among TIR2 cases (OR of malignancy 0.37, 95% CI 0.18–0.78). In TIR3 cases the hard consistency of small nodules was associated with malignity (OR: 3.51, 95% CI 1.84–6.70, p < 0.001), while size alone, irrespective of consistency, was not diagnostically informative. No other significant association was found in TIR2 and TIR3. Abstract: Conclusions: The combination of cytology with clinical and ultrasonographic parameters may improve diagnostic definition of palpable thyroid nodules. However, the need for innovative diagnostic tools is still high.

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalEndocrine
DOIs
Publication statusPublished - 2018

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Thyroid Nodule
Multicenter Studies
Prospective Studies
Cell Biology
Neoplasms
Logistic Models
Sensitivity and Specificity

Keywords

  • Cytology
  • Diagnostic accuracy
  • Multiple correspondence analysis
  • Prospective observational trial
  • Thyroid nodules

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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Predictivity of clinical, laboratory and imaging findings in diagnostic definition of palpable thyroid nodules. A multicenter prospective study. / Chiofalo, Maria Grazia; Signoriello, Simona; Fulciniti, Franco; Avenia, Nicola; Ristagno, Serenella; Lombardi, Celestino Pio; Nicolosi, Angelo; Pelizzo, Maria Rosa; Perigli, Giuliano; Polistena, Andrea; Panebianco, Vincenzo; Bellantone, Rocco; Calò, Pietro Giorgio; Boschin, Isabella Merante; Badii, Benedetta; Di Maio, Massimo; Gallo, Ciro; Perrone, Francesco; Pezzullo, Luciano.

In: Endocrine, 2018, p. 1-8.

Research output: Contribution to journalArticle

Chiofalo, MG, Signoriello, S, Fulciniti, F, Avenia, N, Ristagno, S, Lombardi, CP, Nicolosi, A, Pelizzo, MR, Perigli, G, Polistena, A, Panebianco, V, Bellantone, R, Calò, PG, Boschin, IM, Badii, B, Di Maio, M, Gallo, C, Perrone, F & Pezzullo, L 2018, 'Predictivity of clinical, laboratory and imaging findings in diagnostic definition of palpable thyroid nodules. A multicenter prospective study', Endocrine, pp. 1-8. https://doi.org/10.1007/s12020-018-1577-5
Chiofalo, Maria Grazia ; Signoriello, Simona ; Fulciniti, Franco ; Avenia, Nicola ; Ristagno, Serenella ; Lombardi, Celestino Pio ; Nicolosi, Angelo ; Pelizzo, Maria Rosa ; Perigli, Giuliano ; Polistena, Andrea ; Panebianco, Vincenzo ; Bellantone, Rocco ; Calò, Pietro Giorgio ; Boschin, Isabella Merante ; Badii, Benedetta ; Di Maio, Massimo ; Gallo, Ciro ; Perrone, Francesco ; Pezzullo, Luciano. / Predictivity of clinical, laboratory and imaging findings in diagnostic definition of palpable thyroid nodules. A multicenter prospective study. In: Endocrine. 2018 ; pp. 1-8.
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abstract = "Abstract: Purpose: To assess the role of clinical, biochemical, and morphological parameters, as added to cytology, for improving pre-surgical diagnosis of palpable thyroid nodules. Abstract: Methods: Patients with a palpable thyroid nodule were eligible if surgical intervention was indicated after a positive or suspicious for malignancy FNAC (TIR 4–5 according to the 2007 Italian SIAPEC-IAP classification), or two inconclusive FNAC at a ≥3 months interval, or a negative FNAC associated with one or more risk factor. Reference standard was histological malignancy diagnosis. Likelihood ratios of malignancy, sensitivity, specificity, negative (NPV), and positive predictive value (PPV) were described. Multiple correspondence analysis (MCA) and logistic regression were applied. Abstract: Results: Cancer was found in 433/902 (48{\%}) patients. Considering TIR4–5 only as positive cytology, specificity, and PPV were high (94 and 91{\%}) but sensitivity and NPV were low (61 and 72{\%}); conversely, including TIR3 among positive, sensitivity and NPV were higher (88 and 82{\%}) while specificity and PPV decreased (52 and 63{\%}). Ultrasonographic size ≥3 cm was independently associated with benignity among TIR2 cases (OR of malignancy 0.37, 95{\%} CI 0.18–0.78). In TIR3 cases the hard consistency of small nodules was associated with malignity (OR: 3.51, 95{\%} CI 1.84–6.70, p < 0.001), while size alone, irrespective of consistency, was not diagnostically informative. No other significant association was found in TIR2 and TIR3. Abstract: Conclusions: The combination of cytology with clinical and ultrasonographic parameters may improve diagnostic definition of palpable thyroid nodules. However, the need for innovative diagnostic tools is still high.",
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T1 - Predictivity of clinical, laboratory and imaging findings in diagnostic definition of palpable thyroid nodules. A multicenter prospective study

AU - Chiofalo, Maria Grazia

AU - Signoriello, Simona

AU - Fulciniti, Franco

AU - Avenia, Nicola

AU - Ristagno, Serenella

AU - Lombardi, Celestino Pio

AU - Nicolosi, Angelo

AU - Pelizzo, Maria Rosa

AU - Perigli, Giuliano

AU - Polistena, Andrea

AU - Panebianco, Vincenzo

AU - Bellantone, Rocco

AU - Calò, Pietro Giorgio

AU - Boschin, Isabella Merante

AU - Badii, Benedetta

AU - Di Maio, Massimo

AU - Gallo, Ciro

AU - Perrone, Francesco

AU - Pezzullo, Luciano

PY - 2018

Y1 - 2018

N2 - Abstract: Purpose: To assess the role of clinical, biochemical, and morphological parameters, as added to cytology, for improving pre-surgical diagnosis of palpable thyroid nodules. Abstract: Methods: Patients with a palpable thyroid nodule were eligible if surgical intervention was indicated after a positive or suspicious for malignancy FNAC (TIR 4–5 according to the 2007 Italian SIAPEC-IAP classification), or two inconclusive FNAC at a ≥3 months interval, or a negative FNAC associated with one or more risk factor. Reference standard was histological malignancy diagnosis. Likelihood ratios of malignancy, sensitivity, specificity, negative (NPV), and positive predictive value (PPV) were described. Multiple correspondence analysis (MCA) and logistic regression were applied. Abstract: Results: Cancer was found in 433/902 (48%) patients. Considering TIR4–5 only as positive cytology, specificity, and PPV were high (94 and 91%) but sensitivity and NPV were low (61 and 72%); conversely, including TIR3 among positive, sensitivity and NPV were higher (88 and 82%) while specificity and PPV decreased (52 and 63%). Ultrasonographic size ≥3 cm was independently associated with benignity among TIR2 cases (OR of malignancy 0.37, 95% CI 0.18–0.78). In TIR3 cases the hard consistency of small nodules was associated with malignity (OR: 3.51, 95% CI 1.84–6.70, p < 0.001), while size alone, irrespective of consistency, was not diagnostically informative. No other significant association was found in TIR2 and TIR3. Abstract: Conclusions: The combination of cytology with clinical and ultrasonographic parameters may improve diagnostic definition of palpable thyroid nodules. However, the need for innovative diagnostic tools is still high.

AB - Abstract: Purpose: To assess the role of clinical, biochemical, and morphological parameters, as added to cytology, for improving pre-surgical diagnosis of palpable thyroid nodules. Abstract: Methods: Patients with a palpable thyroid nodule were eligible if surgical intervention was indicated after a positive or suspicious for malignancy FNAC (TIR 4–5 according to the 2007 Italian SIAPEC-IAP classification), or two inconclusive FNAC at a ≥3 months interval, or a negative FNAC associated with one or more risk factor. Reference standard was histological malignancy diagnosis. Likelihood ratios of malignancy, sensitivity, specificity, negative (NPV), and positive predictive value (PPV) were described. Multiple correspondence analysis (MCA) and logistic regression were applied. Abstract: Results: Cancer was found in 433/902 (48%) patients. Considering TIR4–5 only as positive cytology, specificity, and PPV were high (94 and 91%) but sensitivity and NPV were low (61 and 72%); conversely, including TIR3 among positive, sensitivity and NPV were higher (88 and 82%) while specificity and PPV decreased (52 and 63%). Ultrasonographic size ≥3 cm was independently associated with benignity among TIR2 cases (OR of malignancy 0.37, 95% CI 0.18–0.78). In TIR3 cases the hard consistency of small nodules was associated with malignity (OR: 3.51, 95% CI 1.84–6.70, p < 0.001), while size alone, irrespective of consistency, was not diagnostically informative. No other significant association was found in TIR2 and TIR3. Abstract: Conclusions: The combination of cytology with clinical and ultrasonographic parameters may improve diagnostic definition of palpable thyroid nodules. However, the need for innovative diagnostic tools is still high.

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KW - Diagnostic accuracy

KW - Multiple correspondence analysis

KW - Prospective observational trial

KW - Thyroid nodules

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