Predictors and prevalence of paraganglioma syndrome associated with mutations of the SDHC gene

Francesca Schiavi, Carsten C. Boedeker, Birke Bausch, Mariola Peçzkowska, Clara Fuentes Gomez, Thomas Strassburg, Christian Pawlu, Mary Buchta, Maren Salzmann, Michael M. Hoffmann, Ansgar Berlis, Ingo Brink, Markus Cybulla, Mihaela Muresan, Martin A. Walter, Flavio Forrer, Matti Välimäki, Andrzej Kawecki, Zbigniew Szutkowski, Jörg SchipperMartin K. Walz, Pascal Pigny, Catherine Bauters, Joan E. Willet-Brozick, Bora E. Baysal, Andrzej Januszewicz, Charis Eng, Giuseppe Opocher, Hartmut P H Neumann

Research output: Contribution to journalArticlepeer-review

Abstract

Context: Paraganglioma syndrome includes inherited head and neck paragangliomas (HNPs) and adrenal or extra-adrenal pheochromocytomas and are classified according to the susceptibility genes SDHB, SDHC, and SDHD. In contrast with those with germline mutations of the SDHB and SDHD genes, clinical and genetic data on patients with mutations of SDHC are scarce. Objective: To determine the prevalence and clinical characteristics of SDHC mutation carriers compared with patients with SDHB and SDHD mutations and with sporadic cases. Design, Setting, and Patients: Genetic screening for SDHC mutations in an international HNP registry of 121 unrelated index cases and in 371 sporadic cases from a pheochromocytoma registry, conducted January 1, 2001, until December 31, 2004. Identified index cases and affected relatives were clinically evaluated. Main Outcome Measures: Prevalence of and clinical findings for SDHC mutation-associated HNPs vs those with SDHB and SDHD mutations. Results: The prevalence of SDHC carriers was 4% in HNP but 0% in pheochromocytoma index cases. None of the SDHC mutation carriers had signs of pheochromocytoma. We compared HNPs in 22 SDHC mutation carriers with the HNPs of SDHB (n=15) and SDHD (n=42) mutation carriers and with 90 patients with sporadic HNPs. Location, number of tumors, malignancy, and age were different: more carotid body tumors were found in SDHC (13/22 [59%]) than in sporadic HNPs (29/90 [32%], P=.03), as well as fewer instances of multiple tumors in SDHC (2/22) than in SDHD (24/42; P

Original languageEnglish
Pages (from-to)2057-2063
Number of pages7
JournalJournal of the American Medical Association
Volume294
Issue number16
DOIs
Publication statusPublished - Oct 26 2005

ASJC Scopus subject areas

  • Medicine(all)

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