Predictors of adverse outcome among patients with hypertension and coronary artery disease

Carl J. Pepine, Peter R. Kowey, Stuart Kupfer, Rainer E. Kolloch, Athanase Benetos, Giuseppe Mancia, Antonio Coca, Rhonda M. Cooper-Dehoff, Eileen Handberg, Efrain Gaxiola, Peter Sleight, C. Richard Conti, Ann C. Hewkin, Luigi Tavazzi

Research output: Contribution to journalArticle

Abstract

OBJECTIVES: We sought to determine predictors for adverse outcomes in hypertensive patients with coronary artery disease (CAD). BACKGROUND: Factors leading to adverse outcomes in hypertensive patients with CAD are poorly understood. The INternational VErapamil-trandolapril STudy (INVEST) compared outcomes in hypertensive patients with CAD that were assigned randomly to either a verapamil sustained-release (SR)- or an atenolol-based strategy for blood pressure (BP) control. Trandolapril and hydrochlorothiazide were used as added agents. During follow-up (61,835 patient-years), BP control and the primary outcome (death, nonfatal myocardial infarction, and nonfatal stroke) were not different between strategies. METHODS: We investigated risk for adverse outcome associated with baseline factors, follow-up BP, and drug treatments using Cox modeling. RESULTS: Previous heart failure (adjusted hazard ratio [HR] 1.96), as well as diabetes (HR 1.77), increased age (HR 1.63), U.S. residency (HR 1.61), renal impairment (HR 1.50), stroke/transient ischemic attack (HR 1.43), smoking (HR 1.41), myocardial infarction (HR 1.34), peripheral vascular disease (HR 1.27), and revascularization (HR 1.15) predicted increased risk. Follow-up systolic BP

Original languageEnglish
Pages (from-to)547-551
Number of pages5
JournalJournal of the American College of Cardiology
Volume47
Issue number3
DOIs
Publication statusPublished - Feb 7 2006

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ASJC Scopus subject areas

  • Nursing(all)

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Pepine, C. J., Kowey, P. R., Kupfer, S., Kolloch, R. E., Benetos, A., Mancia, G., Coca, A., Cooper-Dehoff, R. M., Handberg, E., Gaxiola, E., Sleight, P., Conti, C. R., Hewkin, A. C., & Tavazzi, L. (2006). Predictors of adverse outcome among patients with hypertension and coronary artery disease. Journal of the American College of Cardiology, 47(3), 547-551. https://doi.org/10.1016/j.jacc.2005.09.031