Predictors of efficacy of androgen-receptor-axis-targeted therapies in patients with metastatic castration-sensitive prostate cancer: A systematic review and meta-analysis

Carlo Buonerba, Matteo Ferro, Pasquale Dolce, Felice Crocetto, Antonio Verde, Giuseppe Lucarelli, Luca Scafuri, Sergio Facchini, Angelo Vaia, Alfredo Marinelli, Daniela Terracciano, Liliana Montella, Nicola Longo, Ciro Imbimbo, Vincenzo Mirone, Giuseppe Di Lorenzo, Sabino De Placido, Guru Sonpavde

Research output: Contribution to journalReview articlepeer-review

Abstract

Background: Both docetaxel and androgen-receptor-axis-targeted (ARAT) agents are approved in metastatic castration-sensitive prostate cancer (mCSPC) patients. Predictive factors of therapy efficacy are lacking. Methods: We included articles reporting data about randomized-controlled clinical trials (RCTs) testing an ARAT agent plus ADT vs. ADT. We aimed to obtain pooled estimates of efficacy outcomes and assess differences in pooled estimates of efficacy outcomes between sub-groups. Results: A total of 5427 mCSPC patients enrolled in five RCTs were evaluable for OS (Overall Survival) and PFS (Progression-free survival). Pooled OS-HR (Hazard Ratio) was 0.66 (95 % CI: 0.60−0.74), while pooled PFS-HR was 0.46 (95 % CI: 0.40−0.53). Combined treatment with docetaxel was associated with differential OS outcomes, while tumor volume according to the CHAARTED criteria and visceral metastasis were associated with differential PFS outcomes. Conclusion: Our results add evidence that ARAT agents improve OS in mCSPC and discourage their combined use with docetaxel in this setting.

Original languageEnglish
Article number102992
JournalCritical Reviews in Oncology/Hematology
Volume151
DOIs
Publication statusPublished - Jul 2020

Keywords

  • Abiraterone
  • Apalutamide
  • Castration-sensitive prostate cancer
  • Enzalutamide

ASJC Scopus subject areas

  • Hematology
  • Oncology

Fingerprint

Dive into the research topics of 'Predictors of efficacy of androgen-receptor-axis-targeted therapies in patients with metastatic castration-sensitive prostate cancer: A systematic review and meta-analysis'. Together they form a unique fingerprint.

Cite this