Predictors of long-term survival after liver transplantation for hepatocellular carcinoma

Claudio Zavaglia, Luciano De Carlis, Alberto Battista Alberti, Ernesto Minola, Luca Saverio Belli, Abdallah Omar Slim, Aldo Airoldi, Alessandro Giacomoni, Gianfranco Rondinara, Carmine Tinelli, Domenico Forti, Giovambattista Pinzello

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Abstract

AIMS: The aim of this study was to identify predictors of both survival and tumor-free survival of a cohort of 155 patients, with hepatocellular carcinoma (HCC) and cirrhosis, who were treated by orthotopic liver transplantation (OLT). METHODS: From January 1989 to December 2002, 603 OLTs were performed in 549 patients. HCC was diagnosed in 116 patients before OLT and in 39 at histological examination of the explanted livers. Eighty-four percent of the patients met "Milan" criteria at histology. Ninety-four patients received anticancer therapies preoperatively. RESULTS: The median follow-up was 49 months (range, 0-178). Overall, 1-, 3-, 5-, and 10-yr survival were 84%, 75%, 72%, and 62%, respectively. Survival was not affected by the patient's age or sex, etiology of liver disease, Child score at transplantation, rejection episodes, tumor number, total tumor burden, bilobar tumor, and pathologic Tumor, Nodes, Metastasis (pTNM) stages. There was no statistically significant difference in survival when patients were grouped according to the recently proposed simplified pTNM staging (5-yr survival, 80% in stage I, 69% in stage II, 50% in stage III, p= 0.3) or the United Network for Organ Sharing (UNOS) staging system for HCC. Encapsulation of the tumor and α-fetoprotein levels significantly affect patient survival. Five-year survival of patients with poorly differentiated (G3) HCC was significantly worse than that of patients with moderately (G2) or well-differentiated (G1) HCC (respectively, G3 44%, G2 67%, and G1 97%, p= 0.0015). Patients with micro- or macro-vascular invasion had a worse 5-yr survival than patients without vascular invasion (49%vs 77%, p= 0.04). Multivariate analysis showed that histological grade of differentiation and macroscopic vascular invasion are independent predictors of survival (HR 2.4, 95% CI 1.4-4.1, p= 0.0009 and HR 2.8, 95% CI 1.2-6.8, p= 0.022). CONCLUSION: Histological grade of differentiation and macroscopic vascular invasion, as assessed on the explanted livers, are strong predictors of both survival and tumor recurrence in patients with cirrhosis who received transplants for HCC.

Original languageEnglish
Pages (from-to)2708-2716
Number of pages9
JournalAmerican Journal of Gastroenterology
Volume100
Issue number12
DOIs
Publication statusPublished - Dec 2005

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Liver Transplantation
Hepatocellular Carcinoma
Survival
Blood Vessels
Neoplasms
Fibrosis
Fetal Proteins
Neoplasm Metastasis
Liver
Graft Rejection
Tumor Burden
Liver Diseases
Histology
Multivariate Analysis
Transplants
Recurrence

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Zavaglia, C., De Carlis, L., Alberti, A. B., Minola, E., Belli, L. S., Slim, A. O., ... Pinzello, G. (2005). Predictors of long-term survival after liver transplantation for hepatocellular carcinoma. American Journal of Gastroenterology, 100(12), 2708-2716. https://doi.org/10.1111/j.1572-0241.2005.00289.x

Predictors of long-term survival after liver transplantation for hepatocellular carcinoma. / Zavaglia, Claudio; De Carlis, Luciano; Alberti, Alberto Battista; Minola, Ernesto; Belli, Luca Saverio; Slim, Abdallah Omar; Airoldi, Aldo; Giacomoni, Alessandro; Rondinara, Gianfranco; Tinelli, Carmine; Forti, Domenico; Pinzello, Giovambattista.

In: American Journal of Gastroenterology, Vol. 100, No. 12, 12.2005, p. 2708-2716.

Research output: Contribution to journalArticle

Zavaglia, C, De Carlis, L, Alberti, AB, Minola, E, Belli, LS, Slim, AO, Airoldi, A, Giacomoni, A, Rondinara, G, Tinelli, C, Forti, D & Pinzello, G 2005, 'Predictors of long-term survival after liver transplantation for hepatocellular carcinoma', American Journal of Gastroenterology, vol. 100, no. 12, pp. 2708-2716. https://doi.org/10.1111/j.1572-0241.2005.00289.x
Zavaglia, Claudio ; De Carlis, Luciano ; Alberti, Alberto Battista ; Minola, Ernesto ; Belli, Luca Saverio ; Slim, Abdallah Omar ; Airoldi, Aldo ; Giacomoni, Alessandro ; Rondinara, Gianfranco ; Tinelli, Carmine ; Forti, Domenico ; Pinzello, Giovambattista. / Predictors of long-term survival after liver transplantation for hepatocellular carcinoma. In: American Journal of Gastroenterology. 2005 ; Vol. 100, No. 12. pp. 2708-2716.
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AU - De Carlis, Luciano

AU - Alberti, Alberto Battista

AU - Minola, Ernesto

AU - Belli, Luca Saverio

AU - Slim, Abdallah Omar

AU - Airoldi, Aldo

AU - Giacomoni, Alessandro

AU - Rondinara, Gianfranco

AU - Tinelli, Carmine

AU - Forti, Domenico

AU - Pinzello, Giovambattista

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N2 - AIMS: The aim of this study was to identify predictors of both survival and tumor-free survival of a cohort of 155 patients, with hepatocellular carcinoma (HCC) and cirrhosis, who were treated by orthotopic liver transplantation (OLT). METHODS: From January 1989 to December 2002, 603 OLTs were performed in 549 patients. HCC was diagnosed in 116 patients before OLT and in 39 at histological examination of the explanted livers. Eighty-four percent of the patients met "Milan" criteria at histology. Ninety-four patients received anticancer therapies preoperatively. RESULTS: The median follow-up was 49 months (range, 0-178). Overall, 1-, 3-, 5-, and 10-yr survival were 84%, 75%, 72%, and 62%, respectively. Survival was not affected by the patient's age or sex, etiology of liver disease, Child score at transplantation, rejection episodes, tumor number, total tumor burden, bilobar tumor, and pathologic Tumor, Nodes, Metastasis (pTNM) stages. There was no statistically significant difference in survival when patients were grouped according to the recently proposed simplified pTNM staging (5-yr survival, 80% in stage I, 69% in stage II, 50% in stage III, p= 0.3) or the United Network for Organ Sharing (UNOS) staging system for HCC. Encapsulation of the tumor and α-fetoprotein levels significantly affect patient survival. Five-year survival of patients with poorly differentiated (G3) HCC was significantly worse than that of patients with moderately (G2) or well-differentiated (G1) HCC (respectively, G3 44%, G2 67%, and G1 97%, p= 0.0015). Patients with micro- or macro-vascular invasion had a worse 5-yr survival than patients without vascular invasion (49%vs 77%, p= 0.04). Multivariate analysis showed that histological grade of differentiation and macroscopic vascular invasion are independent predictors of survival (HR 2.4, 95% CI 1.4-4.1, p= 0.0009 and HR 2.8, 95% CI 1.2-6.8, p= 0.022). CONCLUSION: Histological grade of differentiation and macroscopic vascular invasion, as assessed on the explanted livers, are strong predictors of both survival and tumor recurrence in patients with cirrhosis who received transplants for HCC.

AB - AIMS: The aim of this study was to identify predictors of both survival and tumor-free survival of a cohort of 155 patients, with hepatocellular carcinoma (HCC) and cirrhosis, who were treated by orthotopic liver transplantation (OLT). METHODS: From January 1989 to December 2002, 603 OLTs were performed in 549 patients. HCC was diagnosed in 116 patients before OLT and in 39 at histological examination of the explanted livers. Eighty-four percent of the patients met "Milan" criteria at histology. Ninety-four patients received anticancer therapies preoperatively. RESULTS: The median follow-up was 49 months (range, 0-178). Overall, 1-, 3-, 5-, and 10-yr survival were 84%, 75%, 72%, and 62%, respectively. Survival was not affected by the patient's age or sex, etiology of liver disease, Child score at transplantation, rejection episodes, tumor number, total tumor burden, bilobar tumor, and pathologic Tumor, Nodes, Metastasis (pTNM) stages. There was no statistically significant difference in survival when patients were grouped according to the recently proposed simplified pTNM staging (5-yr survival, 80% in stage I, 69% in stage II, 50% in stage III, p= 0.3) or the United Network for Organ Sharing (UNOS) staging system for HCC. Encapsulation of the tumor and α-fetoprotein levels significantly affect patient survival. Five-year survival of patients with poorly differentiated (G3) HCC was significantly worse than that of patients with moderately (G2) or well-differentiated (G1) HCC (respectively, G3 44%, G2 67%, and G1 97%, p= 0.0015). Patients with micro- or macro-vascular invasion had a worse 5-yr survival than patients without vascular invasion (49%vs 77%, p= 0.04). Multivariate analysis showed that histological grade of differentiation and macroscopic vascular invasion are independent predictors of survival (HR 2.4, 95% CI 1.4-4.1, p= 0.0009 and HR 2.8, 95% CI 1.2-6.8, p= 0.022). CONCLUSION: Histological grade of differentiation and macroscopic vascular invasion, as assessed on the explanted livers, are strong predictors of both survival and tumor recurrence in patients with cirrhosis who received transplants for HCC.

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