Predictors of mortality among intensive care unit patients coinfected with tuberculosis and HIV

Translated title of the contribution: Predictors of mortality among intensive care unit patients coinfected with tuberculosis and HIV

Marcia Danielle Ferreira, Cynthia Pessoa das Neves, Alexandra Brito de Souza, Francisco Beraldi-Magalhães, Giovanni Battista Migliori, Afrânio Lineu Kritski, Marcelo Cordeiro-Santos

Research output: Contribution to journalArticle

Abstract

OBJECTIVE: To identify factors predictive of mortality in patients admitted to the ICU with tuberculosis (TB)/HIV coinfection in the Manaus, Amazon Region.

METHODS: This was a retrospective cohort study of TB/HIV coinfected patients over 18 years of age who were admitted to an ICU in the city of Manaus, Brazil, between January of 2011 and December of 2014. Sociodemographic, clinical, and laboratory variables were assessed. To identify factors predictive of mortality, we employed a Cox proportional hazards model.

RESULTS: During the study period, 120 patients with TB/HIV coinfection were admitted to the ICU. The mean age was 37.0 ± 11.7 years. Of the 120 patients evaluated, 94 (78.3%) died and 62 (66.0%) of those deaths having occurred within the first week after admission. Data on invasive mechanical ventilation (IMV) and ARDS were available for 86 and 67 patients, respectively Of those 86, 75 (87.2%) underwent IMV, and, of those 67, 48 (71.6%) presented with ARDS. The factors found to be independently associated with mortality were IMV (p = 0.002), hypoalbuminemia (p = 0.013), and CD4 count < 200 cells/mm3 (p = 0.002).

CONCLUSIONS: A high early mortality rate was observed among TB/HIV coinfected ICU patients. The factors predictive of mortality in this population were IMV, hypoalbuminemia, and severe immunosuppression.

Original languagePortuguese
Pages (from-to)118-124
Number of pages7
JournalJornal Brasileiro de Pneumologia
Volume44
Issue number2
DOIs
Publication statusPublished - Apr 2018

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Intensive Care Units
Tuberculosis
HIV
Artificial Respiration
Mortality
Hypoalbuminemia
Coinfection
CD4 Lymphocyte Count
Proportional Hazards Models
Immunosuppression
Brazil
Cohort Studies
Retrospective Studies
Population

Cite this

Ferreira, M. D., Neves, C. P. D., Souza, A. B. D., Beraldi-Magalhães, F., Migliori, G. B., Kritski, A. L., & Cordeiro-Santos, M. (2018). Predictors of mortality among intensive care unit patients coinfected with tuberculosis and HIV. Jornal Brasileiro de Pneumologia, 44(2), 118-124. https://doi.org/10.1590/s1806-37562017000000316

Predictors of mortality among intensive care unit patients coinfected with tuberculosis and HIV. / Ferreira, Marcia Danielle; Neves, Cynthia Pessoa das; Souza, Alexandra Brito de; Beraldi-Magalhães, Francisco; Migliori, Giovanni Battista; Kritski, Afrânio Lineu; Cordeiro-Santos, Marcelo.

In: Jornal Brasileiro de Pneumologia, Vol. 44, No. 2, 04.2018, p. 118-124.

Research output: Contribution to journalArticle

Ferreira, MD, Neves, CPD, Souza, ABD, Beraldi-Magalhães, F, Migliori, GB, Kritski, AL & Cordeiro-Santos, M 2018, 'Predictors of mortality among intensive care unit patients coinfected with tuberculosis and HIV', Jornal Brasileiro de Pneumologia, vol. 44, no. 2, pp. 118-124. https://doi.org/10.1590/s1806-37562017000000316
Ferreira, Marcia Danielle ; Neves, Cynthia Pessoa das ; Souza, Alexandra Brito de ; Beraldi-Magalhães, Francisco ; Migliori, Giovanni Battista ; Kritski, Afrânio Lineu ; Cordeiro-Santos, Marcelo. / Predictors of mortality among intensive care unit patients coinfected with tuberculosis and HIV. In: Jornal Brasileiro de Pneumologia. 2018 ; Vol. 44, No. 2. pp. 118-124.
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