Predictors of mortality of idiopathic pulmonary fibrosis

R. Carbone, E. Balleari, M. Grosso, F. Montanaro, Giovanni Bottino, R. Ghio

Research output: Contribution to journalArticlepeer-review

Abstract

Idiopathic pulmonary fibrosis (IPF), a disease with histological features corresponding to usual interstitial pneumonia (UIP), is a disorder of unknown cause. Not only it is the most common subtype of idiopathic interstitial pneumonias but it is also associated with the highest mortality rate. Despite a good number of studies investigating the mortality of-patients with UIP the prognostic factors that have been studied have several limitations. To date it is unclear when in the course of the disease and with what modality these patients should be treated. According to the literature we subcategorized predictors of mortality into (a) baseline predictors; (b) dynamic predictors. IPF perspectives in therapy have been also analyzed. Moreover, the principal aims of this review were: (1) to analyze and to clarify the clinical utility of different prognostic factors for IPF; (2) to enable clinicians to better evaluate the eligibility criteria for lung transplantation in the clinical practice.

Original languageEnglish
Pages (from-to)97-104
Number of pages8
JournalEuropean Review for Medical and Pharmacological Sciences
Volume12
Issue number2
Publication statusPublished - Mar 2008

Keywords

  • Idiopathic pulmonary fibrosis
  • Mortality
  • Outcome
  • Prognostic factors
  • Survival

ASJC Scopus subject areas

  • Pharmacology

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